Analgesic treatment with buprenorphine should be adapted to the mouse strain

Rudeck, Juliane; Vogl, Silvia; Heinl, Céline; Steinfath, Matthias; Fritzwanker, Sebastian; Kliewer, Andrea; Schulz, Stefan; Schönfelder, Gilbert; Bert, Bettina

doi:10.1016/j.pbb.2020.172877

Cited by 17 publications

(15 citation statements)

References 54 publications

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“…After habituation to the test arena activity data in the OF also became repeatable and it would be tempting to speculate that individual differences indeed correlate between home cage and habituated OF arena. Our initial research purpose, which is not the main focus of this manuscript, was to investigate the analgesic effect of buprenorphine in three different mouse strains [41]. In this context, we aimed at the comparison of baseline locomotion with the locomotion after buprenorphine administration.…”

Section: Discussionmentioning

confidence: 99%

“…G 0309/15 and G 0194/16 and were conducted in accordance with the German Animal Protection Law (TierSchG, TierSchVersV). The main purpose of these two studies was the evaluation of the analgesic effect of buprenorphine in three different mouse strains [41]. All decisions regarding strain, sex and age of the animals were made with regard to this research question.…”

Section: Ethics Statementmentioning

confidence: 99%

“…Beside this investigated influencing factors, i.e., two different experiments, three different strains, and the personality of the individual animal, other factors are also important to consider in such kind of analysis. Since this study was a side project of a main explorative research study dealing with the analgesic effect of buprenorphine in different mouse strains we primarily focused on male mice [41]. However, scientific data from literature show that behavioral patterns can differ tremendously between male and female mice [57].…”

Section: Plos Onementioning

confidence: 99%

“…Therefore, the aim of our study was to elucidate the putative hidden information of habituation data in combination with the repeatability analysis for research questions which requires a familiar environment as test situation (for example wheel running, nest building, burrowing behavior or baseline locomotion [3,22,40]). As an example, we investigated retrospectively the effectiveness of intersession habituation of male mice of C57BL/6J, BALB/cJ and 129S1/ SvImJ inbred strains to an OF arena as familiar environment within two different experiments carried out at the same institute (one in winter and one in summer time) [41]. For this purpose, we analyzed video data to assess locomotor parameters in the OF (distance travelled, average activity).…”

Section: Introductionmentioning

confidence: 99%

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Repeatability analysis improves the reliability of behavioral data

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Section: Discussionmentioning

confidence: 99%

Section: Ethics Statementmentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Repeatability analysis improves the reliability of behavioral data

et al. 2020

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“…There is a preclinical literature, primarily in rats, that has identified abnormalities in a wide-variety of structural and functional endpoints following prenatal buprenorphine exposure. Mice have unusual buprenorphine pharmacokinetics including only modest amounts of norbuprenorphine crossing the blood brain barrier (52,137,138) which is unlike sheep (22). Another possibility that could account for the differences among studies is that analytical chemistry procedures have been refined.…”

Section: Prenatal Correlates and Consequencesmentioning

confidence: 99%

An Examination of the Complex Pharmacological Properties of the Non-Selective Opioid Receptor Modulator Buprenorphine

Pande¹,

Piper²

2020

Preprint

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Buprenorphine, an analogue of thebaine, is a Schedule III opioid in the United States used for opioid-use disorder and as an analgesic. Research has shown drugs like buprenorphine have a complicated pharmacology with characteristics that challenge traditional definitions of terms like agonist, antagonist, and efficacy. Buprenorphine has a high affinity for the mu (MOR), delta (DOR), kappa (KOR), and intermediate for the nociceptin opioid receptors (NOR). Buprenorphine is generally described as a partial MOR agonist with limited activity and decreased response at the mu-receptor relative to full agonists. In opioid naïve patients, the drug’s analgesic efficacy is equivalent to a full MOR agonist, despite decreased receptor occupancy and the “ceiling effect” produced from larger doses. Some argue buprenorphine’s effects depend on the endpoint measured, as it functions as a partial agonist for respiratory depression, but a full-agonist for pain. Buprenorphine’s active metabolite, norbuprenorphine, attenuates buprenorphine's analgesic effects due to NOR binding and respiratory depressant effects. The method of administration impacts efficacy and tolerance when administered for analgesia. There have been eleven-thousand reports involving buprenorphine and minors (age < 19) to US poison control centers, the preponderance (89.2%) with children. The consequences of prenatal buprenorphine exposure in experimental animals and humans should continue to be carefully evaluated. In conclusion, buprenorphine’s characterization as only a partial mu-agonist is an oversimplification. Contemporary research shows the traditional explanation of the pharmacology of buprenorphine does not take into account changes to receptor theory, pharmacological terminology, route of administration, and biologically active major metabolites.

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Lipid bound extended release buprenorphine (high and low doses) and sustained release buprenorphine effectively attenuate post‐operative hypersensitivity in an incisional pain model in mice (Mus musculus)

Navarro

Jampachaisri

Huss

et al. 2021

Anim Models and Exp Med

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Background Extended‐release buprenorphine (XR) is indicated for pain management in rodents, but little is known about its use in mice. This study aimed to investigate whether high dose XR effectively attenuates post‐operative hypersensitivity better than low dose XR in a mouse model of incisional pain. Methods Mice (n = 44) were randomly assigned to 1 of 4 treatment groups: (a) saline (1 ml/kg SC, once); (b) sustained release buprenorphine (Bup‐SR, 1 mg/kg SC, once); (c) low dose extended‐release buprenorphine (XR‐lo, 3.25 mg/kg SC, once); (d) high dose extended‐release buprenorphine (XR‐hi, 6.5 mg/kg SC, once). On days −1, 0 (4 hours), 1, 2, and 3, mechanical and thermal hypersensitivities were evaluated, and plasma buprenorphine concentrations were measured. Results Mechanical (days 0‐2) and thermal (days 0‐1) hypersensitivities were observed in the saline group. Bup‐SR, XR‐lo, and XR‐hi attenuated mechanical hypersensitivity on days 0, 1, and 2. None of the treatment groups, except XR‐Lo on day 0, attenuated thermal hypersensitivity on days 0 or 1. Plasma buprenorphine concentration peaked at 4 hours (day 0) in all treatment groups and remained greater than 1 ng/mL on days 0‐2. No abnormal clinical observations or gross pathologic findings were seen in any groups. Conclusion The results indicate XR‐hi did not effectively attenuate post‐operative hypersensitivity better than XR‐lo. Thus both 3.25 and 6.5 mg/kg XR are recommended for attenuating post‐operative hypersensitivity for at least up to 48 hours in mice.

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Analgesic treatment with buprenorphine should be adapted to the mouse strain

Cited by 17 publications

References 54 publications

Repeatability analysis improves the reliability of behavioral data

Repeatability analysis improves the reliability of behavioral data

An Examination of the Complex Pharmacological Properties of the Non-Selective Opioid Receptor Modulator Buprenorphine

Lipid bound extended release buprenorphine (high and low doses) and sustained release buprenorphine effectively attenuate post‐operative hypersensitivity in an incisional pain model in mice (Mus musculus)

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