Analgesic effect of preoperative intravenous administration of paracetamol on post-cesarean pain: A randomized clinical trial

Abstract

Background: Pain control after every surgery, especially cesarean is very important, and physicians are striving to discover pain control methods using the least amount of opioid. Paracetamol is a non-opioid analgesic with few complications. The present study was aimed to investigate the analgesic effect of preoperative intravenous administration of paracetamol on post-cesarean pain. Methods: This randomized double-blind clinical trial was conducted on 240 pregnant women under spinal anesthesia who were candidate for elective cesarean. The patients’ weight, height, age and body mass index (BMI) were recorded, and patients were randomly divided into two equal groups (n=120). In the first group, 10 mg/kg paracetamol in 100cc normal saline (paracetamol group) and in the second group 100cc normal saline (control group) administered 15 minutes before surgery intravenously. Blood pressure, pulse rate, chills and nausea were recorded during and 1 hour after surgery, and pain visual analogue scale (VAS) and need for additional analgesic were recorded 1, 2, 4, 6, 12 and 24 hours after surgery. Results : The mean scores of pain were significantly lower in paracetamol group (4.01±2.22) than control group 6 hours (4.83±2.35) (p=0.008) and 24 hours (2.26±1.85 and 2.67±1.80 respectably) (p=0.038) after surgery. Mean meperidine consumed was lower in paracetamol group than control group but not significantly. No significant difference was found between the two groups in frequency of chills and nausea (p>0.05). Conclusions : Within the limitations of the current study, preoperative intravenous administration of paracetamol significantly reduced post-cesarean pain within 24 hours. Trial registration: The proposal of present study approved by the Research Council of Rafsanjan University of Medical Sciences with No. 841 on 2016-11-08 and by the ethics committee of Rafsanjan University of Medical Sciences, with code IR.RUMS.REC.1395.115 on 2016-11-08 (prospectively registered), and approved by the Iranian Registry of Clinical Trial (IRCT) with code IRCT20150519022320N17 on 2019-01-18 (retrospectively registered). https://www.irct.ir

Manajemen Nyeri Terkini pada Pasien Pasca Seksio Sesarea

“…Beberapa penelitian lain menilai efektivitas paracetamol intravena dan menyimpulkan bahwa asetaminofen intravena pada periode pascabedah setelah prosedur SS menghasilkan penurunan konsumsi narkotik untuk kontrol nyeri. 1,8,9 Ketika dibandingkan dengan tramadol intravena, paracetamol mencapai kontrol nyeri yang sama memuaskan dengan tramadol setelah SS. Akan tetapi, tramadol menyebabkan efek samping yang signifikan pada ibu dibandingkan dengan paracetamol.…”