Analgesic Effect of Intraarticular Morphine after Arthroscopic Knee Surgery

Stein, Christoph; Comisel, K.; Haimerl, E.; Yassouridis, Alexander; Lehrberger, K.; Herz, A.; Peter, K.

doi:10.1056/nejm199110173251602

Cited by 565 publications

(195 citation statements)

References 11 publications

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“…According to recommendations given by Stein et al, 19 we gave morphine intra-articularly at a dose of 1 mg and found a similar effect. A morphine infusion given into the joint during arthrocentesis substantially decreases pain and this could be useful at the rate of 90%.…”

Section: Discussionmentioning

confidence: 58%

Comparative study in patients with symptomatic internal derangements of the temporomandibular joint: analgesic outcomes of arthrocentesis with or without intra-articular morphine and tramadol

Sipahi¹,

Satilmis²,

Basa³

2015

British Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 58%

Comparative study in patients with symptomatic internal derangements of the temporomandibular joint: analgesic outcomes of arthrocentesis with or without intra-articular morphine and tramadol

Sipahi¹,

Satilmis²,

Basa³

2015

British Journal of Oral and Maxillofacial Surgery

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“…analgesic effect was abolished by the opioid antagonist naloxone. These findings indicate that peripheral opioid receptors can mediate analgesia (Stein, 1991). Are there cytokines other than TNF-a, lL-1 P. and IL-6 or factors other than CRF which affect peripheral opioid analgesia?…”

Section: Ruman Studies Of Peripheral Opioid Analgesiamentioning

confidence: 97%

“…Obviously, analgesia in humans is the ultimate goal of pain research and several studies using surgery patients have been performed by Christoph Stein (1991). His findings, summarized below, justifY further investigations into this field .…”

Section: Ruman Studies Of Peripheral Opioid Analgesiamentioning

confidence: 99%

Peripheral Opioid Analgesia

Figliola¹

1999

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Peripheral Opioid AnalgesiaMary Cranford Figliola, Master of Science, 1999 Thesis directed by Brian M. Cox, Ph.D, Chairman, Department of Ph anna co logy Exogenous and endogenous opioid compounds are known to have analgesic effects.Endogenous opioid compounds include endorphin, enkephalin and dynorphin which are differentially processed from precursor peptides depending on the site of their production.These peptides exert their effects through at least three opioid receptors: mll, delta and kappa. Exogenous opioid compounds can exert a more potent analgesic action but are accompanied by deleterious side effects including respiratory depression and addiction.These side effects are centrally mediated and until recently the analgesic actions of opioids were believed to occur in the CNS as well . Recent laboratory and clinical studies indicate that in the presence of inflammation endogenous and exogenous opioids have analgesic effects in the periphery. Certain immune factors are involved resulting in increased endogenous opioid peptides at the site of injury and resulting in increased opioid receptors at the nerve terminal allowing for peripheral opioid analgesia.

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“…In den 1980er Jah ren wur de der pe ri phe ren Opioidanalge sie wie der ver mehrt Auf merk sam keit geschenkt und die ge won ne nen ex pe ri mentel len Er geb nis se konn ten 1991 in der ersten kon trol lier ten kli ni schen Stu die zur pe ri phe ren Opioidanal ge sie bei in tra ar tiku lä rer Ap pli ka ti on von Mor phin nach arthro sko pi schen Ein grif fen am Knie ge lenk ins Hu man mo dell über tra gen wer den [70,71]. Seit her ist der Zu wachs an ex pe ri mentel len und kli ni schen Da ten durch die zuneh men de An zahl an Stu di en, die das Kon zept der Schmerz kon trol le durch die pe ri phe re Ap pli ka ti on von Opioiden [68] ver deut li chen, groß.…”

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Anwendungsmöglichkeiten und Stellenwert der peripheren Opioidanalgesie

Oeltjenbruns

Schäfer

2005

Schmerz

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Recently, the local application of analgesic substances has attracted much interest and has become increasingly relevant in daily clinical practice. The lack of the well-known therapy-limiting central side effects of systemically administered opioids is a clear advantage of "peripheral opioid analgesia". Important prerequisites for the occurrence of peripheral analgesic effects of opioids are good accessibility of the painful site, presence of clinically relevant pain, signs of a local inflammation, exclusion of a fast systemic absorption, and adequately potent analgesic substances. This review gives an outline of recent experience with various clinical applications of "peripheral opioid analgesia".

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Analgesic Effect of Intraarticular Morphine after Arthroscopic Knee Surgery

Abstract: Low doses of intraarticular morphine can significantly reduce pain after knee surgery through an action specific to local opioid receptors that reaches its maximal effect three to six hours after injection.

Cited by 565 publications

References 11 publications

Comparative study in patients with symptomatic internal derangements of the temporomandibular joint: analgesic outcomes of arthrocentesis with or without intra-articular morphine and tramadol

Comparative study in patients with symptomatic internal derangements of the temporomandibular joint: analgesic outcomes of arthrocentesis with or without intra-articular morphine and tramadol

Peripheral Opioid Analgesia

Anwendungsmöglichkeiten und Stellenwert der peripheren Opioidanalgesie

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