Analgesic effect of inhaled lavender essential oil for frenotomy in healthy neonates: a randomized clinical trial

Maya-Enero, Silvia; Fàbregas-Mitjans, Montserrat; Llufriu-Marquès, Rosa Maria; Candel-Pau, Júlia; Garcia-Garcia, Jordi; López-Vílchez, María Ángeles

doi:10.1007/s12519-022-00531-7

Cited by 5 publications

(6 citation statements)

References 21 publications

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“…Goubet conducted the rst study of aromatherapy with neonates in 2003 [33]. Aromatherapy has been used to treat pain in infants, showing an objective improvement in neonatal pain scale scores, decreased heart rate, shorter crying time, and prevention of decreased oxygen saturation [3,4,6,12,17,20]. The main aromas used in neonatology are lavender, vanilla, amniotic uid and human milk [3,34].…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, this is the rst study to evaluate the effect of inhaled LEO vs VEO as pain relief during neonatal frenotomy. In a previous clinical trial, which we conducted, we observed a signi cant decrease in crying time and NIPS scores in the LEO exposed group when compared to the control group and traditional pain control measures [17]. When planning this clinical trial, we chose VEO because it is the second most used aroma (apart from breastmilk) in neonatology.…”

Section: Discussionmentioning

confidence: 99%

“…In a former clinical trial (NCT04877392), we compared the use of common pain control strategies (swaddling, administration of oral sucrose, and suck for two minutes prior to the procedure) with the use of those plus inhaled LEO, and observed that signs of pain (duration of crying and NIPS score) were lower in the experimental group. From that moment on, we have routinely used inhaled LEO when performing a frenotomy [17]. Other authors have observed the bene ts of using vanilla (Vanilla fragrans) essential oil (VEO) for pain control in neonates [18,19].…”

Section: Introductionmentioning

confidence: 99%

“…Our hypothesis was that signs of pain (mostly crying time and NIPS score) would be lower in the experimental group than in the control group. We chose LEO and VEO because these are the fragrances for which more studies have been performed in neonates and infants [3,4,6,12,17,[19][20][21][22][23][24][25][26][27]. As far as we know, there are no previous studies which have analyzed the potential bene t of LEO vs VEO to relieve pain in neonatal frenotomy.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: a randomized clinical trial (NCT04867824)

Maya-Enero

Fàbregas-Mitjans

Llufriu-Marquès

et al. 2022

Preprint

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Background: It is necessary to treat neonatal pain because it may have short and long-term adverse effects. Frenotomy is a painful procedure where sucking, a common strategy to relieve pain, cannot be used because the technique is performed on the tongue. In a previous randomized clinical trial, we demonstrated that inhaled lavender essential oil (LEO) reduced the signs of pain during neonatal frenotomy. We aimed to find out whether inhaled vanilla essential oil (VEO) is more effective in reducing pain during frenotomy than LEO.Methods: Randomized clinical trial with neonates who underwent a frenotomy for type 3 tongue-ties between May and October 2021. Pain was assessed using pre and post-procedure heart rate (HR) and oxygen saturation (SatO2), crying time and NIPS score. Patients were randomized into “experimental” and “control” group. In both groups, we performed swaddling, administered oral sucrose, and let the newborn suck for two minutes. We placed a gauze pad with one drop of LEO (control group) or of VEO (experimental group) under the neonate’s nose for two minutes prior to and during the frenotomy.Results: We enrolled 142 patients (71 per group). Both groups showed similar NIPS scores (2.02 vs 2.38) and crying times (15.3 vs 18.7 s). We observed no differences in HR increase or in SatO2 decrease between both groups. We observed no side effects in either of the groups.Conclusions: We observed no appreciable difference between LEO and VEO, therefore we cannot conclude which of them was more effective in treating pain in neonates who underwent a frenotomy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: a randomized clinical trial (NCT04867824)

Maya-Enero

Fàbregas-Mitjans

Llufriu-Marquès

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…In a former clinical trial (NCT04877392), we compared the use of common pain control strategies (swaddling, administration of oral sucrose, and suck for 2 min prior to the procedure) with the use of those plus inhaled LEO and observed that signs of pain (duration of crying and NIPS score) were lower in the experimental group. From that moment on, we have routinely used inhaled LEO when performing a frenotomy [19]. Other authors have observed the benefits of using vanilla (Vanilla fragrans) essential oil (VEO) for pain control in neonates [20,21].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: a randomized clinical trial (NCT04867824)

et al. 2022

Self Cite

View full text Add to dashboard Cite

It is necessary to treat neonatal pain because it may have short-and long-term adverse effects. Frenotomy is a painful procedure where sucking, a common strategy to relieve pain, cannot be used because the technique is performed on the tongue. In a previous randomized clinical trial, we demonstrated that inhaled lavender essential oil (LEO) reduced the signs of pain during neonatal frenotomy. We aimed to find out whether inhaled vanilla essential oil (VEO) is more effective in reducing pain during frenotomy than LEO. Randomized clinical trial with neonates who underwent a frenotomy for type 3 tongueties between May and October 2021. Pain was assessed using pre and post-procedure heart rate (HR) and oxygen saturation (SatO2), crying time, and NIPS score. Neonates were randomized into "experimental" and "control" group. In both groups, we performed swaddling, administered oral sucrose, and let the newborn suck for 2 min. We placed a gauze pad with one drop of LEO (control group) or of VEO (experimental group) under the neonate's nose for 2 min prior to and during the frenotomy. We enrolled 142 neonates (71 per group). Both groups showed similar NIPS scores (2.02 vs 2.38) and crying times (15.3 vs 18.7 s). We observed no differences in HR increase or in SatO2 decrease between both groups. We observed no side effects in either of the groups.Conclusions: We observed no appreciable difference between LEO and VEO; therefore, we cannot conclude which of them was more effective in treating pain in neonates who underwent a frenotomy.Trial registration: This clinical trial is registered with www. clini caltr ials. gov with NCT04867824. What is Known:• Pain management is one of the most important goals of neonatal care as it can have long-term neurodevelopmental effects.• Lavender essential oil can help relieve pain due to its sedative, antispasmodic, and anticolic properties.What is New:• Lavender and vanilla essential oils are safe, beneficial, easy to use, and cheap in relieving pain in neonates who undergo a frenotomy for type 3 tongue-ties.

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Non-pharmacological management of infant and young child procedural pain

Riddell

Bucsea

Shiff

et al. 2023

Cochrane Database of Systematic Reviews

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Analgesic effect of inhaled lavender essential oil for frenotomy in healthy neonates: a randomized clinical trial

Cited by 5 publications

References 21 publications

Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: a randomized clinical trial (NCT04867824)

Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: a randomized clinical trial (NCT04867824)

Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: a randomized clinical trial (NCT04867824)

Non-pharmacological management of infant and young child procedural pain

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