Analgesic drug use in pregnancy and neurodevelopment outcomes: an umbrella review

Kwok, Janell; Luedecke, Emily; Hall, Hildigunnur Anna; Murray, Aja Louise; Auyeung, Bonnie

doi:10.1016/j.neubiorev.2022.104607

Cited by 8 publications

(4 citation statements)

References 26 publications

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“…In vivo animal studies suggest a causal relationship between prenatal APAP exposure and altered behaviors in the offspring, such as stereotyped behavior and hyperactivity [142,143]. These effects have been attributed to APAP's reduction of BDNF levels in the striatum of rats [144,145], as well as alterations in dopamine metabolism [142,143]. Moreover, APAP may also cause oxidative stress and mitochondrial dysfunction, which can contribute to behavioral abnormalities [135].…”

Section: Apap and Asdmentioning

confidence: 99%

Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder

Csoka,

El Kouhen,

Bennani

et al. 2024

Biomolecules

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by severe deficits in social communication and interaction, repetitive movements, abnormal focusing on objects, or activity that can significantly affect the quality of life of the afflicted. Neuronal and glial cells have been implicated. It has a genetic component but can also be triggered by environmental factors or drugs. For example, prenatal exposure to valproic acid or acetaminophen, or ingestion of propionic acid, can increase the risk of ASD. Recently, epigenetic influences on ASD have come to the forefront of investigations on the etiology, prevention, and treatment of this disorder. Epigenetics refers to DNA modifications that alter gene expression without making any changes to the DNA sequence. Although an increasing number of pharmaceuticals and environmental chemicals are being implicated in the etiology of ASD, here, we specifically focus on the molecular influences of the abovementioned chemicals on epigenetic alterations in neuronal and glial cells and their potential connection to ASD. We conclude that a better understanding of these phenomena can lead to more effective interventions in ASD.

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Section: Apap and Asdmentioning

confidence: 99%

Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder

Csoka,

El Kouhen,

Bennani

et al. 2024

Biomolecules

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“…Drugs that belongs to the above category are aspirin, ibuprofen, naproxen and acetaminophen. 52 NSAIDs are cyclooxygenase enzyme inhibitors that are widely used by 19% of the population for their analgesic, antipyretic, and anti-inflammatory properties. NSAIDS are often used in the first trimester and are generally avoided in the third trimester owing to adverse effects.…”

Section: Analgesic Use In Pregnancymentioning

confidence: 99%

A review on the impact of analgesic use during pregnancy on stillbirth

Girish¹,

Johns²,

Meghana³

et al. 2023

IJOGR

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Stillbirth is a tragic complication of the pregnancy which is associated with emotional, social and economic disturbances. Stillbirth can be a result of advanced maternal age, smoking, obesity, comorbid conditions, poor economic status, drug use during pregnancy, etc. Though evidences suggest a number of factors contributing to stillbirth, use of analgesics adds an extra burden for the occurrence of stillbirth. Every drug has its own set of pros and cons, which may directly or indirectly affect the foetal health. Drug exposure was associated with the two-fold increased risk of stillbirth in pregnancy. Due to lack of significant evidence suggesting the occurrence of stillbirth which is a result of analgesic use, control over the use of analgesics during pregnancy is not well established. Hence, in the current literature review, the risk of analgesic-induced stillbirth is highlighted. The misuse of analgesics as over-the-counter medicines is widely known. Painkillers are often used to self-medicate without the supervision of a medical practitioner. Some of these drugs tend to cross the placental barrier and can have hazardous effects on foetus. Many circumstances might drive a pregnant woman to use analgesics which includes pain associated with the adaptation of mother’s body to the change during pregnancy. Due to ease of access and lack of knowledge about foetal risk, analgesics are consumed irrationally leading to pregnancy-related complications such as stillbirth.

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“…Although nearly 9 in 10 pregnant individuals use medication (Lupattelli et al, 2014), only 5% of medications have been adequately monitored, tested, and labelled with safety information for use during pregnancy and lactation (Byrne et al, 2020). Most existing evidence is, moreover, focused on immediate birth outcomes following exposure to medication during pregnancy, whereas there are clear indications that some medications may also affect long-term health outcomes in offspring (Kwok et al, 2022;Dreier et al, 2023). This lack of knowledge hampers evidence-based benefit-risk assessment of prescribing and using medications in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Editorial: Long term effects of prenatal exposure to medications and vaccines

van Gelder,

Zoega,

Cohen

2024

Front. Pharmacol.

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Analgesic drug use in pregnancy and neurodevelopment outcomes: an umbrella review

Cited by 8 publications

References 26 publications

Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder

Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder

A review on the impact of analgesic use during pregnancy on stillbirth

Editorial: Long term effects of prenatal exposure to medications and vaccines

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