Analgesic Concentrations of Lidocaine Suppress Tonic A-delta and C Fiber Discharges Produced by Acute Injury

Tanelian, Darrell L.; Maclver, M. B.

doi:10.1097/00000542-199105000-00020

Cited by 199 publications

(73 citation statements)

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“…The acute outbreak of zoster may damage the peripheral nerve apparatus from the dorsal root to cutaneous nerve endings [16][17][18] . Surviving but damaged cutaneous nociceptor fibers in the area of pain may have abnormal spontaneous activity and be sensitized to mechanical or other stimuli [19][20][21][22][23] . These changes may in part be due to accumulation of sodium channels at the injury sites [23][24][25] .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Piroxicam Patch Compared to Lidocaine Patch for the Treatment of Postherpetic Neuralgia

et al. 2011

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Background:The lidocaine patch has been effectively used as a first-line therapy to treat neuropathic pain such as postherpetic neuralgia (PHN). Objective: To evaluate the safety and efficacy of the topical piroxicam patch as a treatment option for the treatment of PHN. Methods: Eighteen patients completed a 3-session study, applying three different patches (lidocaine, piroxicam and control) in random order. A maximum of three patches were applied to the most painful area for three consecutive days (12 hours on followed by 12 hours off). Each session was conducted at least seven days apart. The changes in visual analog scale (VAS) scores based pain intensity, quality of sleep and adverse effects were recorded. Results: When compared to the control, both the lidocaine and piroxicam patches significantly reduced the mean VAS scores of pain intensity of all different types. However, the lidocaine patch was better at reducing allodynia, whereas the piroxicam patch was more effective for dull pain. The lidocaine patch worked faster than the piroxicam patch for the response to overall pain relief. Conclusion: The results of this study suggest the use of the piroxicam patch for dull pain and in patients where the lidocaine patch is contraindicated. (Ann Dermatol 23(2) 162∼169, 2011)

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Section: Discussionmentioning

confidence: 99%

Efficacy of Piroxicam Patch Compared to Lidocaine Patch for the Treatment of Postherpetic Neuralgia

et al. 2011

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“…Therapeutic plasma levels and duration of IVLT for acute pain management are not well defined, although the optimal therapeutic range for acute pain treatment appears to be between 1 and 5 μg/ml [6,24,[117][118][119][120]. Only preservative free formulations should be given intravenously.…”

Section: Myoclonic Jerks Dysphoria/hallucinationsmentioning

confidence: 99%

“…Systemic administration of local anaesthetics provides clinical analgesia in a broad range of neuropathic pain states [23,117,[137][138][139][140]. IVLT induces global analgesia and dampens the neuro-inflammatory response in pain [126,[141][142][143][144].…”

Section: The Rationale For Ivlt In the Management Of Painmentioning

confidence: 99%

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A Review of Intravenous Lidocaine Infusion Therapy for Paediatric Acute and Chronic Pain Management

Lauder¹

2017

Pain Relief - From Analgesics to Alternative Therapies

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Pediatric acute and chronic pain experiences involve the interaction of physiological, psychological, behavioural, developmental, pharmacological and situational factors. In the acute perioperative pain setting preventative multimodal analgesia is required to provide comfort and minimise the potential for "wind-up" and central sensitisation. When pain is recurrent, ongoing or chronic some children embark on a downward spiral of decreased physical, psychological and social functioning. The multidisciplinary team management approach is a well-established standard of care for children with complex chronic pain. Intravenous lidocaine has peripheral and central mediated analgesic, anti-inflammatory and anti-hyperalgesic properties. Intravenous lidocaine infusion therapy (IVLT) has been shown to be effective in the management of acute and chronic pain in adults. This chapter will present the rational for IVLT in pediatric pain management with emphasis on preventative multimodal therapy in acute pain and the multidisciplinary treatment approach in chronic pain. Large multi-centre randomised controlled trials are required to provide the evidence-base to confirm that IVLT is indeed an effective and safe treatment option in acute preventative multimodal analgesia and as an adjunct in the multidisciplinary care of chronic pain in the pediatric population. Keywords

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“…Electrophysiologic studies aimed at elucidating the site at which lidocaine and tocainide exert their antinociceptive action provide compelling evidence in support of a central site of action. [14][15][16] With regard to a peripheral mechanism, animal models of nerve injury 14,[17][18][19][20] and a model of phantom limb pain in humans 21 seem to indicate that after nerve injury peripheral mechanisms may develop that are responsive to the blockade of sodium channels.…”

Section: Solutionmentioning

confidence: 99%

Lidocaine and Mexiletine Therapy for Erythromelalgia

Kuhnert

Phillips²,

Davis³

1999

Arch Dermatol

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Analgesic Concentrations of Lidocaine Suppress Tonic A-delta and C Fiber Discharges Produced by Acute Injury

Cited by 199 publications

References 0 publications

Efficacy of Piroxicam Patch Compared to Lidocaine Patch for the Treatment of Postherpetic Neuralgia

Efficacy of Piroxicam Patch Compared to Lidocaine Patch for the Treatment of Postherpetic Neuralgia

A Review of Intravenous Lidocaine Infusion Therapy for Paediatric Acute and Chronic Pain Management

Lidocaine and Mexiletine Therapy for Erythromelalgia

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