Analgesic and Antiinflammatory Effects of the Tannin Fraction fromMyracrodruon urundeuva Fr. All.

Abstract

The present work showed a significant antinociceptive activity in the tannin fraction (TF) extracted from the bark of Myracrodruon urundeuva Fr. All. This inhibitory effect was demonstrated not only against abdominal contractions but also in the formalin test in mice. In the first case, at doses of 0.1 and 1 mg/kg, i.p. the TF caused inhibitions of the order of 39.6% and 80.8%, respectively, and in the second one, inhibitions of 47.8% and 77.2% (phase I) and 59.2% and 100% (phase II), after the administration of 5 and 10 mg/kg, i.p. The antinociceptive effect was partially reverted by naloxone. The TF presented also an antioedematogenic effect in rat paw oedema induced by carrageenan as well as dextran. In the carrageenan model, significant inhibitions were seen at 2 h (29.7% and 41.7%) and 3 h (40.5% and 44.2%), after administration of 5 and 10 mg/kg, i.p. In the dextran induced oedema, the TF (10 mg/kg, p.o.) caused inhibitions of 29.2%, 42.4% and 54.5% at 2 h, 3 h and 4 h, respectively. The TF (10 and 25 mg/kg, i.p.) significantly inhibited the inflammatory events (vesical oedema and increased vascular permeability) which occur at the onset of the haemorrhagic cystitis induced by cyclophosphamide. After subcutaneous or oral administration, the TF (5–50 mg/kg) also blocked neutrophil migration induced by direct (fMLP) as well as indirect (carrageenan) stimuli. © 1997 by John Wiley & Sons, Ltd.

Chalcones from Myracrodruon urundeuva are efficacious in guinea pig ovalbumin-induced allergic conjunctivitis

“…There is no report in the literature concerning the use of M. urundeuva chalcones in allergic conjunctivitis, although most of the popular use of its stem bark aqueous extract is related to the antiinflammatory as well as antihistaminic properties (Menezes & Rao, 1988;Viana et al, 1997;Rodrigues et al, 2002;Bandeira et al, 1994). In the present work, morphometric analyses showed that chalcones present potent anti-inflammatory and anti-allergic effects, in conjunctivitis induced by ovalbumin in guinea pigs.…”

Standardization and Stability Evaluation of Dry Extracts of Myracrodruon Urundeuva Allemão Obtained by Spray Drier

“…Thus it is possible that compounds present in the M. urundeuva extract interfere with the inflammatory process mediated by these substances. Several studies have demonstrated the anti-inflammatory activity of extracts of M. urundeuva [3,[40][41][42]. This study showed the drying process by spray drier maintained chemical constituents of the extract responsible for anti-inflammatory activities of the plant.…”

Analgesic and Antipyretic Activities of Methanol Extract and Its Fraction from the Root ofSchoenoplectus grossus

“…Several studies conducted on medicinal plants revealing the presence of secondary metabolites like flavonoids and alkaloids have been linked to possess analgesic, antipyretic, and other properties [ 38 , 40 ]. There are also similar studies on medicinal plants suggesting role of tannins in suppression of pain and inflammatory activities [ 31 , 41 ]. Flavonoids are the main constituents that have capacity to interfere with eicosanoids biosynthesis pathways [ 42 – 44 ] and are suggested to decrease the release of arachidonic acid through inhibition of neutrophils degranulation [ 45 ].…”