Analgesic and antiinflammatory activities of Justicia pectoralis Jacq and its main constituents: coumarin and umbelliferone

Molybdenum Disulfide Nanosheet-Based Nanocomposite for the Topical Delivery of Umbelliferone: Evaluation of Anti-inflammatory and Analgesic Potentials

“…Both these formulations have shown greater potential than that of other treatments (F2 as well as control) at all-time points as the nanocomposite (F1) and diclofenac emulgel restricted the edema to 26.6 ± 3.2 and 32.2 ± 3.2%, respectively. The results of rat paw edema treatment by a UMB-containing formulation show significantly reduced edema with improved antinociceptive effects, which was also found when anti-inflammatory and analgesic activities of Justicia pectoralis (contains UMB) were evaluated. ,, Similarly, anti-inflammatory activity and edema inhibition were noted in the case of the UMB-matrix film loaded phospholipid complex in carrageenan-induced paw edema in rats . Thus, the results of our study have shown that the UMB–MoS 2 nanocomposite gel (F1) provided the significant inhibition in the paw edema, which was in agreement with the earlier reports. , The improved anti-inflammatory activity of F1 advocates for the additive effect of MoS 2 acting as an anti-inflammatory agent itself in addition to the role of nanocarriers along with UMB.…”

“…The results of rat paw edema treatment by a UMB-containing formulation show significantly reduced edema with improved antinociceptive effects, which was also found when anti-inflammatory and analgesic activities of Justicia pectoralis (contains UMB) were evaluated. 12 , 70 , 71 Similarly, anti-inflammatory activity and edema inhibition were noted in the case of the UMB-matrix film loaded phospholipid complex in carrageenan-induced paw edema in rats. 8 Thus, the results of our study have shown that the UMB–MoS 2 nanocomposite gel (F1) provided the significant inhibition in the paw edema, which was in agreement with the earlier reports.…”

“…The potential analgesic activity of UMB-containing formulations in this study is in agreement with the previous reports. 70 , 71 A detailed statistical analysis performed by one-way ANOVA followed by Bonferroni’s multiple comparison test by GraphPad Prism for comparative analgesic activity is mentioned in Table S1 (Supporting Information), and best-fit values after linear regression analysis of the anti-inflammatory data are summarized in Table S2 (Supporting Information). Similarly, improved pain relieving effects of UMB formulations in the carrageenan-based rat model were noted in previous reports, where they proved that the antinociceptive effect of UMB was through the nitric-oxide system rather than opioid-based system by inhibiting the centrally as well as peripherally acting chemical pain mediators.…”

Effects of umbelliferone in a murine model of allergic airway inflammation

“…Umbelliferone is one of several coumarins with anti-inflammatory activity already reported (Hoult and Payá 1996;Lino et al, 1997). In our study it was extracted from T. domingensis (Typhaceae), a species widely distributed in north-east Brazil, especially found in damp areas and in shallow water, lakes and river margins, used for water and soil metal decontamination (Taggart et al, 2005;França, 2006;Maine et al, 2007).…”

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

“…Chemical composition. Coumarins (mainly coumarin and umbelliferone); flavonoids (e.g., quercetin, kaempferol, swertisin, and derivatives) ( Lino et al, 1997 ; Oliveira et al, 2000 ); lignans (e.g., justicidin B) ( Joseph et al, 1988 ).…”