Analgesic and acetylcholinesterase inhibition potential of polyphenols from Scolopia crenata (Flacourtiaceae): An endemic medicinal plant of India

Rajkumar, Gopalan; Manian, S.

doi:10.1016/j.indcrop.2015.03.090

Cited by 18 publications

(12 citation statements)

References 52 publications

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“…Up to date, searching for new AchE inhibitors derived from natural sources with few side effects is required (Hasbal et al, 2014) but no relevant studies have been reported about anticholinesterase activity of fennel, dill and anise exposed to Zn excess which prompted us to concentrate on the efficiency of our samples for AchE inhibition. Among several investigations, Gomathi and Manian (2015) suggested the effectively AchE inhibitory effect stem bark and leaves of Stevia crenata might be attributed to their increased amounts of nonenzymatic antioxidants.…”

Section: Zn Effects On Inhibitory Activity Of Enzymesmentioning

confidence: 99%

Growth, photosynthetic pigments, phenolic content and biological activities of Foeniculum vulgare Mill., Anethum graveolens L. and Pimpinella anisum L. (Apiaceae) in response to zinc

Majdoub

El-Guendouz

Rezgui

et al. 2017

Industrial Crops and Products

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We thank you for your e-mail of 24 July 2017 with the comments on our manuscript (MS) INDCRO-D-17-01815R2 on "Growth, photosynthetic pigments, phenols and in vitro biological activities of aqueous anise, dill and fennel extracts in response to 2 mM Zinc". We have read it carefully and we do understand most of the referee's comments. Please find bellow our reply and comments following each point raised by the reviewers. All corrections and additions performed in the MS text have been marked in blue. Reviewers' comments: Reviewer #1: The revised version of the manuscript INDCRO-D-17-01815R2 meets all the criteria of scientific work. Paper may be published after several technical corrections:-Suggestion for the title (please accept the proposal, the current version is incorrect): Growth, photosynthetic pigments, phenolic content and biological activities of Foeniculum vulgare Mill., Anethum graveolens L. and Pimpinella anisum L. (Apiaceae) in response to zinc RESPONSE:This proposal made by reviewer 1 was taken into account.

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Section: Zn Effects On Inhibitory Activity Of Enzymesmentioning

confidence: 99%

Growth, photosynthetic pigments, phenolic content and biological activities of Foeniculum vulgare Mill., Anethum graveolens L. and Pimpinella anisum L. (Apiaceae) in response to zinc

Majdoub

El-Guendouz

Rezgui

et al. 2017

Industrial Crops and Products

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“…Essential oils and their constituents, monoterpenes and sesquiterpenes, have several pharmacological properties, among them the potential analgesic effect. (Bahmani et al, 2014;Gomathi and Manian, 2015;de Oliveira Juńior et al, 2018). However, these products are often unexplored (Leonardão et al, 2016), and this fact collaborates to promote the scientific hypothesis related to the antinociceptive effect, including performing the molecular anchorage studies.…”

Section: Introductionmentioning

confidence: 97%

Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review

et al. 2020

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Introduction: Pain is considered an unpleasant sensory and emotional experience, being considered as one of the most important causes of human suffering. Computational chemistry associated with bioinformatics has stood out in the process of developing new drugs, through natural products, to manage this condition. Objective: To analyze, through literature data, recent molecular coupling studies on the antinociceptive activity of essential oils and monoterpenes. Data source: Systematic search of the literature considering the years of publications between 2005 and December 2019, in the electronic databases PubMed and Science Direct. Eligibility Criteria: Were considered as criteria of 1) Biological activity: non-clinical effects of an OE and/or monoterpenes on antinociceptive activity based on animal models and in silico analysis, 2) studies with plant material: chemically characterized essential oils and/or their constituents isolated, 3) clinical and non-clinical studies with in silico analysis to assess antinociceptive activity, 4) articles published in English. Exclusion criteria were literature review, report or case series, meta-analysis, theses, dissertations, and book chapter. Results: Of 16,006 articles, 16 articles fulfilled all the criteria. All selected studies were non-clinical. The most prominent plant families used were Asteraceae, Euphorbiaceae, Verbenaceae, Lamiaceae, and Lauraceae. Among the phytochemicals studied were a-Terpineol, 3-(5-substituted-1,3,4-oxadiazol-2-yl)-N′-[2-oxo-1,2-dihydro-3H-indol-3ylidene] propane hydrazide, b-cyclodextrin complexed with citronellal, (−)-a-bisabolol, b-cyclodextrin complexed with farnesol, and p-Cymene. The softwares used for docking studies were Molegro Virtual Docker, Sybyl ® X, Vlife MDS, AutoDock Vina, Hex Protein Docking, and AutoDock 4.2 in PyRx 0.9. The molecular targets/complexes used were Nitric Oxide Synthase, COX-2, GluR2-S1S2, TRPV1, b-CD complex, CaV 1 , CaV 2.1 , CaV 2.2 , and CaV 2.3 , 5-HT receptor, delta receptor, kappa receptor, and MU (m)

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“…Quantitative analyses showed that total phenol content was present in greater amount in rhizome than in stem while flavonoid content was higher in stem. Numerous researches on different plants reported diverse pharmacological effects including antinociceptive, antiinflammatory and antipyretic effects of phenols (Boussouf et al, 2017;Gomathi & Manian, 2015;Nguyen et al, 2017) and flavonoids (Chen et al, 2016;Owoyele et al, 2008;Wang et al, 2014). As rhizome and stem extract of S. dichotomus possess similar phytoconstituents; hence, both extracts are anticipated to show analogous effects.…”

Section: Phytochemical Analysismentioning

confidence: 99%

Sex-dependent variations in anti-nociceptive and antipyretic effects of rhizome and stem extract of Schumannianthus dichotomus Roxb. in male and female mice

et al. 2020

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Schumannianthus dichotomus (Roxb.) is a perennial shrub from Marantaceace family. In traditional medicine, rhizome of the plant is used in fever and stem is used in earache. We aimed to substantiate these therapeutic claims by examining their effects in mice model. Antinociceptive effect was evaluated by three pain models and antipyretic effect was tested by yeast induced hyperthermia experiment. Influence of mice sexes on these pharmacological effects was examined by performing experiments separately on male and female mice. Quantitative analyses of total phenols and flavonoids were performed. Antinociceptive effects showed striking sex dimorphism. In hind paw licking test, male mice showed significant reductions in licking in both phases for both rhizome and stem extracts while significant effect was observed only in late phase in female mice. In writhing test, antinociception is more profound in male than in female. In hot plate test, stem was more effective than rhizome in male mice while female mice produced little effect for both extracts. Antipyretic experiment also showed varied effect in male and female mice; both extracts showed significant decrease in body temperatures. Rhizome showed greater effect in female mice while stem was more effective in male mice. Total phenol and flavonoid in rhizome were found 103.08 mg GAE (gallic acid equivalent) and 9.07mg QE (quercetin equivalent) respectively while in stem, these were 43.39mg GAE and 20.93 QE. Antinociceptive and antipyretic effects of rhizome and stem extracts endorsed the traditional uses of S. dichotomus. Also, differential effects based on mouse sex indicate the prerequisite of both male and female mice model in therapeutic evaluations of plant extract.

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Analgesic and acetylcholinesterase inhibition potential of polyphenols from Scolopia crenata (Flacourtiaceae): An endemic medicinal plant of India

Cited by 18 publications

References 52 publications

Growth, photosynthetic pigments, phenolic content and biological activities of Foeniculum vulgare Mill., Anethum graveolens L. and Pimpinella anisum L. (Apiaceae) in response to zinc

Growth, photosynthetic pigments, phenolic content and biological activities of Foeniculum vulgare Mill., Anethum graveolens L. and Pimpinella anisum L. (Apiaceae) in response to zinc

Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review

Sex-dependent variations in anti-nociceptive and antipyretic effects of rhizome and stem extract of Schumannianthus dichotomus Roxb. in male and female mice

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