Analgesia and non-aspirin, non-steroidal anti-inflammatory drugs for osteoarthritis of the hip

Stenting complex aortic arch obstructions

“…Consequently, the efficacy of diclofenac in pain relief should be considerably better and also result in fewer side effects compared with ibuprofen, naproxen, and piroxicam. This was, however, not confirmed by Towheed et al, who summarized the literature on the efficacy and side effects of NSAIDs in hip OA (1). Moreover, this supposed better efficacy and fewer side effects of diclofenac suggest that diclofenac could be taken longer than ibuprofen, naproxen, and piroxicam.…”

Stenting complex aortic arch obstructions

“…Consequently, the efficacy of diclofenac in pain relief should be considerably better and also result in fewer side effects compared with ibuprofen, naproxen, and piroxicam. This was, however, not confirmed by Towheed et al, who summarized the literature on the efficacy and side effects of NSAIDs in hip OA (1). Moreover, this supposed better efficacy and fewer side effects of diclofenac suggest that diclofenac could be taken longer than ibuprofen, naproxen, and piroxicam.…”

EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)

“…One systematic review has been undertaken for non-aspirin NSAIDs in the treatment of hip OA, in which 14 placebo controlled trials were reviewed. 47 The ES for pain relief was 0.69 (95% CI 0.12 to 1.26) and the NNT to obtain clinical benefit over placebo was 4 (95% CI 3 to 6), supporting the use of NSAIDs for hip OA (table 3). However, the GI safety of NSAIDs counters their benefits.…”

Number needed to treat (NNT): implication in rheumatology clinical practice

“…For the treatment of hip OA, different analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) were compared in a single systematic review. 22 A significant improvement in pain was seen when etodolac and tenoxicam were compared with placebo. The NNT for a four week treatment with etodolac was For knee OA, only low level laser treatment, which is one of the modalities used in physiotherapy, was systematically reviewed.…”

Stenting complex aortic arch obstructions

“…Consequently, the efficacy of diclofenac in pain relief should be considerably better and also result in fewer side effects compared with ibuprofen, naproxen, and piroxicam. This was, however, not confirmed by Towheed et al, who summarized the literature on the efficacy and side effects of NSAIDs in hip OA (1). Moreover, this supposed better efficacy and fewer side effects of diclofenac suggest that diclofenac could be taken longer than ibuprofen, naproxen, and piroxicam.…”

EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)

“…One systematic review has been undertaken for non-aspirin NSAIDs in the treatment of hip OA, in which 14 placebo controlled trials were reviewed. 47 The ES for pain relief was 0.69 (95% CI 0.12 to 1.26) and the NNT to obtain clinical benefit over placebo was 4 (95% CI 3 to 6), supporting the use of NSAIDs for hip OA (table 3). However, the GI safety of NSAIDs counters their benefits.…”

Number needed to treat (NNT): implication in rheumatology clinical practice

“…For the treatment of hip OA, different analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) were compared in a single systematic review. 22 A significant improvement in pain was seen when etodolac and tenoxicam were compared with placebo. The NNT for a four week treatment with etodolac was For knee OA, only low level laser treatment, which is one of the modalities used in physiotherapy, was systematically reviewed.…”

Stenting complex aortic arch obstructions

“…Consequently, the efficacy of diclofenac in pain relief should be considerably better and also result in fewer side effects compared with ibuprofen, naproxen, and piroxicam. This was, however, not confirmed by Towheed et al, who summarized the literature on the efficacy and side effects of NSAIDs in hip OA (1). Moreover, this supposed better efficacy and fewer side effects of diclofenac suggest that diclofenac could be taken longer than ibuprofen, naproxen, and piroxicam.…”

EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)

“…One systematic review has been undertaken for non-aspirin NSAIDs in the treatment of hip OA, in which 14 placebo controlled trials were reviewed. 47 The ES for pain relief was 0.69 (95% CI 0.12 to 1.26) and the NNT to obtain clinical benefit over placebo was 4 (95% CI 3 to 6), supporting the use of NSAIDs for hip OA (table 3). However, the GI safety of NSAIDs counters their benefits.…”

Number needed to treat (NNT): implication in rheumatology clinical practice

“…For the treatment of hip OA, different analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) were compared in a single systematic review. 22 A significant improvement in pain was seen when etodolac and tenoxicam were compared with placebo. The NNT for a four week treatment with etodolac was For knee OA, only low level laser treatment, which is one of the modalities used in physiotherapy, was systematically reviewed.…”