Anaerobic exercise reduces tumor growth, cancer cachexia and increases macrophage and lymphocyte response in Walker 256 tumor-bearing rats

Lima, C.D.; Alves, Luciana e Sá; Iagher, Fabíola; Machado, Andressa Franzoi; Bonatto, Sandro José Ribeiro; Kuczera, Diogo; Souza, Carine Ferreira de; Pequito, Daniele; Muritiba, Ana Lúcia; Nunes, Everson Araújo; Fernandes, Luíz Cláudio

doi:10.1007/s00421-008-0849-9

Cited by 59 publications

(49 citation statements)

References 43 publications

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“…The improvement of muscle depletion was associated with a small but significant decline in tumor burden in exercised, EPA-treated mice. This observation is consistent with previous data showing that PRT in Waker-256 bearing rats strongly reduced tumor growth [43], while swimming exercise attenuated colon carcinogenesis in the rat [44]. On the contrary, however, another study reported that tumorigenesis increased in p53-deficient mice exercised with a treadmill protocol similar to the one used in the present study [45].…”

Section: Discussionsupporting

confidence: 94%

Combined approach to counteract experimental cancer cachexia: eicosapentenoic acid and training exercise

Penna

Busquets

et al. 2013

Nutrition, Metabolism and Cardiovascular Diseases

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Cancer cachexia is a syndrome characterized by loss of skeletal muscle protein, depletion of lipid stores, anorexia, weakness, and perturbations of the hormonal homeostasis. Despite several therapeutic approaches were described in the past, effective interventions countering cancer cachexia are still lacking.The aim of the present work was to verify the ability of eicosapentaenoic acid (EPA) to prevent the muscle depletion in Lewis lung carcinoma-bearing mice and to test the ability of progressive resistance training (PRT) to increase the EPA effect.EPA alone did not prevent the muscle loss induced by tumor growth, while the combination with PRT induced a partial rescue of muscle strength and mass. The association of EPA and PRT reduced the dramatic PAX-7 accumulation and stimulated the increase of PCG-1 protein.Overall, the present data suggest PRT as an effective tool that should be added on combined therapeutic approaches against cancer cachexia.

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Section: Discussionsupporting

confidence: 94%

Combined approach to counteract experimental cancer cachexia: eicosapentenoic acid and training exercise

Penna

Busquets

et al. 2013

Nutrition, Metabolism and Cardiovascular Diseases

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“…It is well accepted that moderate-intensity exercise has an important influence on the immune system. [30][31][32] The link between exercise and the immune system includes the metabolic approach involving amino acid, carbohydrate, and lipid metabolism changes in the neuroendocrine system. 32,33 Furthermore, some studies have shown that lipid peroxidation and free radicals increase in humans and animals after physical activity.…”

mentioning

confidence: 99%

The effect of physical training on the N-methyl-N-nitrosourea-induced mammary carcinogenesis of Sprague–Dawley rats

Malicka

Siewierska

Puła

et al. 2015

Exp Biol Med (Maywood)

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The impact of physical activity on carcinogenesis has been demonstrated in many studies. Taking into account the discrepant results of physical exercise on the cell proliferation and apoptosis of breast cancer, we aimed to examine the impact of physical training on N-methyl-N-nitrosourea-(MNU)-induced mammary carcinogenesis. Fifty female rats were divided into four groups according to the intensity of physical activity they undertook. The number of developed tumors, tumor volume, and histopathological diagnoses were noted. Apoptosis and cell proliferation were studied by the number of TUNEL-positive and Ki-67-expressing cells. We demonstrated a statistically significant decrease in the tumor number between all trained groups and the control group. The results were most pronounced in the group with a moderate intensity of training. Moreover, we showed a decrease in tumor volume as training intensity increased, though the differences were not statistically significant. The mean number of TUNEL-positive cancer cells was significantly higher in the training groups than in the control group. These data suggest that physical training, especially of moderate intensity, may alleviate MNU-induced mammary carcinogenesis. The results could suggest that physical exercise-induced apoptosis may be a protective mechanism.

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“…Walker 256 tumor-bearing rat offers an opportunity to investigate cancer cachexia and tumor growth due to its characteristics of inducing a higher level of cachexia in only 14 days Data are presented as mean ± SEM of 3 independent measurements [1]. A lot of diseases have been linked to lifestyle, diet, smoking and sedentary lifestyle.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that exercise changes tumor progression [1,2] as well as improves wellbeing and quality of life of cancer patients [3,4]. These changes in tumor progression appear to be related to a process called lipid peroxidation (LP).…”

Section: Introductionmentioning

confidence: 99%

Exercise and Shark Liver Oil Supplementation Reduce Tumor Growth and Cancer Cachexia in Walker 256 Tumor Bearing Rats

Bordignon¹

2014

J Cancer Sci Ther

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This study investigated whether exercise associated to shark liver oil supplementation (1 g/kg b.w./day) affects tumor growth, cachexia, lipid peroxidation and proteins expression involved in cell death in Walker 256 tumorbearing rats. Animals were divided into 4 groups: sedentary tumor-bearing (W), sedentary tumor-bearing shark liver oil supplemented (WSL), exercised tumor-bearing (EW) and exercised tumor-bearing shark liver oil supplemented (EWSL). Training sessions consisted of 6 bouts, 30 seconds each with 50% body-weight load attached to the trunk followed by 1 minute of resting (jump training). Five minutes after the finish jump training the exercise groups were subjected to 30 minutes of continuous swimming with a load equivalent to 6% of body weight, 4 times a week during 8 weeks. Tumor cells were injected at the 6 th training week and all groups were killed 15 days post inoculation. Tumor weight (g) in W group was of 26.50 ± 1.79 and in the WSL, EW and EWSL was of 14.08 ± 0.91, 15.60 ± 0.55 and 12.60 ± 1.07, respectively. The group W showed hypoglycemia (68.67 ± 2.12 mg/dl), hyperlactacidemia (1.49 ± 0.06 mmol/L), hypertriacylglycerolemia (161.4 ± 9.4 mg/dl) and body weight reduction (13.21 ± 2.25 g) characterizing cachexia state. The groups WSL, EW and EWSL presented reduction of tumor cells proliferation ex vivo, and the production of hydroperoxide and apoptosis was increased. Bax/Bcl-2 expression ratio was increased only in the exercised groups. Shark liver oil supplementation and exercise alone were able in to avoid the installation of cachexia state and also reduced tumor growth, but the association of both cause further effect only in the tumor growth.

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Anaerobic exercise reduces tumor growth, cancer cachexia and increases macrophage and lymphocyte response in Walker 256 tumor-bearing rats

Cited by 59 publications

References 43 publications

Combined approach to counteract experimental cancer cachexia: eicosapentenoic acid and training exercise

Combined approach to counteract experimental cancer cachexia: eicosapentenoic acid and training exercise

The effect of physical training on the N-methyl-N-nitrosourea-induced mammary carcinogenesis of Sprague–Dawley rats

Exercise and Shark Liver Oil Supplementation Reduce Tumor Growth and Cancer Cachexia in Walker 256 Tumor Bearing Rats

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