Anabolic agents: what is beyond osteoporosis?

Liu, Yi; Levack, Ashley E.; Marty, Eric; Or, Omer; Samuels, Blossom; Redko, Mariya; Lane, Joseph M.

doi:10.1007/s00198-018-4507-8

Cited by 27 publications

(29 citation statements)

References 82 publications

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“…Although the consideration of PTH or PTHrP in such other instances has merit, they are not discussed in this review in order to focus on fracture healing. In addition, they are covered elsewhere . Abstracts and the full text of the matched articles were collected.…”

Section: Methodsmentioning

confidence: 99%

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Effects of Intermittent Administration of Parathyroid Hormone and Parathyroid Hormone‐Related Protein on Fracture Healing: A Narrative Review of Animal and Human Studies

Yamashita

McCauley

2019

JBMR Plus

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Intermittent administration of parathyroid hormone (PTH) stimulates skeletal remodeling and is a potent anabolic agent in bone. PTH‐related protein (PTHrP) is anabolic acting on the same PTH1 receptor and is in therapeutic use for osteoporosis. The body of literature for PTH actions in fracture healing is emerging with promising yet not entirely consistent results. The objective of this review was to perform a literature analysis to extract up‐to‐date knowledge on the effects of intermittent PTH and PTHrP therapy in bone fracture healing. A literature search of the PubMed database was performed. Clinical case studies and articles related to “regeneration,” “implant,” and “distraction osteogenesis” were excluded. A narrative review was performed to deliberate the therapeutic potential of intermittent PTH administration on fracture healing. A smaller number of studies centered on the use of PTHrP or a PTHrP analog were also reviewed. Animal studies clearly show that intermittent PTH therapy promotes fracture healing and revealed the strong therapeutic potential of PTH. Human subject studies were fewer and not as consistent as the animal studies yet provide insight into the potential of intermittent PTH administration on fracture healing. Differences in outcomes for animal and human studies appear to be attributed partly to variable doses, fracture sites, age, remodeling patterns, and bone architectures, although other factors are involved. Future studies to examine the dose, timing, and duration of PTH administration will be necessary to further delineate the therapeutic potential of PTH for fracture healing in humans. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

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Section: Methodsmentioning

confidence: 99%

“…In addition, they are covered elsewhere. (11)(12)(13)(14)(15) Abstracts and the full text of the matched articles were collected. References cited in the identified articles were also screened for inclusion.…”

Section: Methodsmentioning

confidence: 99%

Effects of Intermittent Administration of Parathyroid Hormone and Parathyroid Hormone‐Related Protein on Fracture Healing: A Narrative Review of Animal and Human Studies

Yamashita

McCauley

2019

JBMR Plus

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“…There have already been several studies presenting the effects of teriparatide for bone formation, fusion, and defect healing. 8 10 11) …”

Section: Discussionmentioning

confidence: 99%

Fracture-dislocation of L5 Combined with Multi-level Traumatic Spondylolisthesis of the Lower Lumbar Spine Treated via the Posterior-only Approach: A Case Report

Park

Kim

et al. 2020

Korean J Neurotrauma

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Fracture-dislocation of the lower lumbar spine, which is commonly caused by high-impact trauma and can lead to instability in the spine, is relatively rare. Surgical treatment is indicated to restore spinal balance, weight-bearing ability, and decompression of the neural elements. There are various available surgical options, including the posterior-only or anterior-only approaches, or a combination of them. However, there is still no definite classification and treatment strategy for fracture-dislocation of the lower lumbar spine. In this report, we describe a 65-year-old man presenting cauda equina syndrome caused by a fracture-dislocation of L5 combined with multi-level traumatic spondylolisthesis of the lower lumbar spine. The patient was treated via the posterior-only approach with neural decompression and anterior reconstruction with posterior instrumentation. We discuss the reasons why the posterior-only approach was decided upon and several meaningful points during the surgery in detail.

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“…143 Such applications include but are not limited to osteoporosis, periodontal regeneration, jaw osteonecrosis, spine fusion, arthroplasty, and fracture healing. 144,145 Much of the rationale for these applications is based on the role of PTH in mineral and skeletal homeostasis as well as PTHrP in chondrocyte regulation within the developing and postnatal growth plate. 146 Intermittent administration of large PTH1-34 or PTH1-84 doses have increased trabecular bone mass in both animal models and osteoporotic patient populations.…”

Section: Growth Factor-based Therapymentioning

confidence: 99%

Calvarial Versus Long Bone: Implications for Tailoring Skeletal Tissue Engineering

Wang

Gilbert

Zhang

et al. 2020

Tissue Engineering Part B: Reviews

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Tissue-engineered graft substitutes have shown great potential to treat large bone defects. While we usually assume that therapeutic approaches developed for appendicular bone healing could be similarly translated for application in craniofacial reconstruction and vice versa, this is not necessarily accurate. In addition to those more well-known healing-associated factors, such as age, lifestyle (e.g., nutrition and smoking), preexisting disease (e.g., diabetes), medication, and poor blood supply, the developmental origins and surrounding tissue of the wound sites can largely affect the fracture healing outcome as well as designed treatments. Therefore, the strategies developed for long bone fracture repair might not be suitable or directly applicable to skull bone repair. In this review, we discuss aspects of development, healing process, structure, and tissue engineering considerations between calvarial and long bones to assist in designing the tailored bone repair strategies.

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Anabolic agents: what is beyond osteoporosis?

Cited by 27 publications

References 82 publications

Effects of Intermittent Administration of Parathyroid Hormone and Parathyroid Hormone‐Related Protein on Fracture Healing: A Narrative Review of Animal and Human Studies

Effects of Intermittent Administration of Parathyroid Hormone and Parathyroid Hormone‐Related Protein on Fracture Healing: A Narrative Review of Animal and Human Studies

Fracture-dislocation of L5 Combined with Multi-level Traumatic Spondylolisthesis of the Lower Lumbar Spine Treated via the Posterior-only Approach: A Case Report

Calvarial Versus Long Bone: Implications for Tailoring Skeletal Tissue Engineering

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