Like the internal digestive system, the largest organ of our body, the skin, maintains a healthy balance with the natural inhabitants of it. Skin act as a host for several microorganisms (about one million per square centimetre) including different types of bacteria, fungi, and viruses. This microbiome takes active role in the fighting with infection, providing protection against environmental damage, regulation of pH and in keeping the skin hydrated and healthy. Probiotics are live and healthy microorganisms that can be consumed directly to restore the pH levels and the balance in the guts. They act like good bacteria and are important to keep away the “bad” bacteria from multiplying in different organ of human body. They can also be applied on the skin to restore the skin's ecosystem, pH and immunity. Again, long term exposure to solar radiation may induce UV damaged skin cancer. The utilization of probiotic bacteria in skin cancer research may help in development of new skin cancer prevention and treatment options.