An update on histamine receptors and the gastrointestinal tract

Hirschowitz, Basil I.

doi:10.1007/bf01308297

Cited by 7 publications

(1 citation statement)

References 61 publications

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“…It is of first importance in many pathological reactions in the gut [2] and could also be involved in physiological regulatory processes, although unequivocal proof is still lacking [2,3]. However, knowledge about regulation of histamine content of intestinal mucosa is still scarce.…”

Section: Introductionmentioning

confidence: 98%

Histamine content, diamine oxydase and histidine decarboxylase activities along the intestinal tract of the rat

1989

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Histamine is widely distributed in the intestine where it is involved in many pathological reactions. The relations between histamine content, diamine oxidase and histidine decarboxylase activity have been investigated along rat's intestine. Results showed significant variations along the intestine. A correlation was observed between histamine and histidine decarboxylase (p less than 0.01), both of them being even in the small intestine (11.8 +/- 2.3 ng/mg ww and 112.5 +/- 21.2 fmoles/hr/mg ww respectively), significantly higher in the caecum (16.3 +/- 1.9 and 178 +/- 20.1) and significantly smaller in the colon (7.3 +/- 1.1 and 65.3 +/- 11.5) than in other intestinal segments. Diamine oxydase activity was higher in ileum (30.7 +/- 7.2 pmoles/min/mg ww) than in jejunum (17.1 +/- 2.8), caecum (4.3 +/- 0.8) and colon (2.6 +/- 2.7), and could not be linked to histamine content. The results fitted in the hypothesis that histamine in rat intestine is mainly located in mast cells where HDC is probably the main enzyme involved in its modulation.

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Section: Introductionmentioning

confidence: 98%

Histamine content, diamine oxydase and histidine decarboxylase activities along the intestinal tract of the rat

1989

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Effects of cimetidine and ranitidine on basal gastric pH, free and total acid content in pigs

Sangiah

Amouzadeh

Barron

et al. 1990

Research in Veterinary Science

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The effects of intramuscular administration of multiple doses of cimetidine and ranitidine on basal gastric pH, free and total acid content from young adult pigs were studied. Cimetidine (4.5 mg kg-1, four times a day, intramuscularly, for three days) significantly (P less than 0.05) raised the basal gastric pH above 3.5 with a simultaneous reduction in free acid content at two, three and 26 hours after the administration of the eighth dose. Ranitidine (0.75 mg kg-1, four times a day, intramuscularly, for three days) significantly (P less than 0.05) raised the basal gastric pH above 3.5 with a concomitant reduction in free acid content at three and 38 hours after the administration of the eight dose. Neither cimetidine nor ranitidine had any significant effects on total acid content. These results confirm that the pig is a basal acid secretor and that the pharmacodynamics and pharmacokinetics of cimetidine and ranitidine in pigs might be different from those in humans.

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Effects of cimetidine and ranitidine on basal gastric pH, free and total acid contents in horses

Sangiah

Amouzadeh

Barron

et al. 1988

Research in Veterinary Science

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An update on histamine receptors and the gastrointestinal tract

Cited by 7 publications

References 61 publications

Histamine content, diamine oxydase and histidine decarboxylase activities along the intestinal tract of the rat

Histamine content, diamine oxydase and histidine decarboxylase activities along the intestinal tract of the rat

Effects of cimetidine and ranitidine on basal gastric pH, free and total acid content in pigs

Effects of cimetidine and ranitidine on basal gastric pH, free and total acid contents in horses

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