An update of neurological manifestations of vasculitides and connective tissue diseases: a literature review

Bougea, Anastasia; Anagnostou, Evangelos; Spandideas, Nikolaos; Triantafyllou, Nikolaos; Kararizou, Evangelia

doi:10.1590/s1679-45082015rw3308

Cited by 18 publications

(13 citation statements)

References 32 publications

(114 reference statements)

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“…La afectación del SNC es poco frecuente y una característica particular de la GNP (7)(8)(9). El compromiso en sistema nervioso periférico, se describe hasta en 67% de casos (9,10).…”

Section: Discussionunclassified

Paquimeningitis y glomerulonefritis crescéntica en vasculitis p-ANCA: Reporte de caso

Contreras¹,

Segovia-Vargas

García

et al. 2018

Acta Med Col

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Las vasculitis asociadas a anticuerpos contra el citoplasma del neutrófilo configuran patologías multisistémicas caracterizadas por afectar pequeños vasos. Se ha reportado compromiso de sistema nervioso central en 2% a 8% de los casos, rara vez al inicio del cuadro clínico. Se reporta el caso de un hombre de 67 años de edad con vasculitis p-ANCA, quien debutó con proptosis, paquimeningitis y disfagia severa. Posteriormente deterioro renal, necesidad de hemodiálisis, ciclofosfamida y recambio plasmático terapéutico con lo cual alcanza criterios de remisión parcial y egresa de diálisis. Las vasculitis ANCA se relacionan con una amplia gama de signos y síntomas inespecíficos. La edad de aparición, creatinina inicial y requerimiento de diálisis, son factores pronósticos. El inicio oportuno del tratamiento es fundamental, requiriendo por tanto un alto índice de sospecha

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“…La afectación del SNC es poco frecuente y una característica particular de la GNP (7)(8)(9). El compromiso en sistema nervioso periférico, se describe hasta en 67% de casos (9,10).…”

Section: Discussionunclassified

Paquimeningitis y glomerulonefritis crescéntica en vasculitis p-ANCA: Reporte de caso

Contreras¹,

Segovia-Vargas

García

et al. 2018

Acta Med Col

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“…Churg and Strauss reported three primary histopathological alterations: Eosinophilic tissue infiltration, necrotizing vasculitis and extravascular granulomas. The inflammatory process in Churg-Strauss syndrome tends to affect smaller epineural arterioles than those in systemic vasculitis [17].…”

Section: Case Reportmentioning

confidence: 97%

“…Therefore, the neuropathy is caused mainly by nerve ischemia due to occlusion of vasa nervorum. The result of this infarction is a loss of sensory and motor axons [17].…”

Section: Case Reportmentioning

confidence: 99%

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Peripheral Neuropathy as Initial Manifestation of Churg-Strauss Syndrome

Antonio¹

2019

Int Arch Intern Med

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Mild deficit of proximal strength in the lower limbs. Not sensory levels. He was able to walk on points and heels. Laboratory examination revealed white blood count 28.5 × 10 9 (eosinophils 61%); C-reactive protein level was 62 mg/dL (normally 0.0-5.0 mg/dL); creatine kinase and transaminase levels was increased, respectively 62 mg/dL and 93 mg/dL. Chest x-ray and head computed tomography scan were normal. The patient was admitted in the neurological ward. Blood exams confirmed leukocytosis with hypereosinophilia. Serum tests were positive for ANCA. Nerve conduction studies showed a neurogenic suffering of the investigated muscles, compatible with axonal motor nerve distress with blocks of motor conduction and sensory axonal suffering with asymmetric distribution; these findings were suggestive of multiplex mononeuritis. Nerve biopsy showed features of axonopathy. Muscle biopsy showed a picture with features of eosinophilic vasculitis. Spirometry was normal, with a FEV1/FVC rate of 77% of predicted. He was treated with intravenous methyl-prednisolone and Cyclophosphamide, followed by maintenance with azathioprine. After some days of therapy a blood exam control showed: White blood count 20.5 × 10 9 (eosinophils 5%); C-reactive protein level 5 mg/dL; creatine kinase levels 51 mg/dL, and transaminase levels 30 mg/dL. Patient improved and there was no recurrence of symptoms since about two years of follow-up.

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“…El compromiso del sistema nervioso periférico ocurre en el 15% de pacientes con ACG, observándose mononeuritis múltiple (como en este caso) y polineuropatía simétrica sensorial y motora (23).…”

Section: Conversatorio Clínico / Clinical Converstoryunclassified

Caso clínico 02-2018. Mujer 76 años con cefalea, dolor articular y disfagia de rápida instauración

et al. 2018

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An update of neurological manifestations of vasculitides and connective tissue diseases: a literature review

Cited by 18 publications

References 32 publications

Paquimeningitis y glomerulonefritis crescéntica en vasculitis p-ANCA: Reporte de caso

Paquimeningitis y glomerulonefritis crescéntica en vasculitis p-ANCA: Reporte de caso

Peripheral Neuropathy as Initial Manifestation of Churg-Strauss Syndrome

Caso clínico 02-2018. Mujer 76 años con cefalea, dolor articular y disfagia de rápida instauración

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