An unusual tubular apocrine adenoma

An unusual presentation of a congenital benign apocrine hamartoma

“…Histologically our case is also unique in that it displays features of SCAP in the superficial part of the lesion and characteristics of TAA in the deeper portion. The immunohistochemical and ultrastructural studies provide evidence of apocrine differentiation, in agreement with previous studies (2,3,8). GCDEP-15 is a glycoprotein purified from human breast gross cystic disease fluid and it is localized to: a) apocrine gland epithelia, including apocrine glands of the axilla, perineum, external auditory canal and eyelid; b) benign metaplastic apocrine epithelium ofthe breast; c) breast carcinomas with apocrine histologic features; d) extramammary Paget's disease; and e) benign sweat gland tumors of the skin of probable apocrine differentiation including SCAP (8)(9)(10).…”

“…Tubular apocrine adenoma (TAA) and syringocystadenoma papilliferum (SGAP) are both rare apocrine tumors. TAA usually clinically appears as a smooth surfaced or verrucous papule or nodule on the head or neck (1)(2)(3). SGAP commonly occurs as a congenital lesion with 75% of cases being located on the face or scalp.…”

Syringocystadenoma Papilliferum With Sebaceous Differentiation in an Intradermal Tubular Apocrine Component. Report of a Case

“…This part of the lesion is microscopically identical to tubular apocrine adenoma (TAA), a rare tumor first reported by Landry and Winkelmann in association with a nevus sebaceus. 15 Some examples of SCAP may have an intradermal tubular component identical to TAA, and such lesions have sometimes been referred to as combined SCAP and TAA, [16][17][18] but other authors regard these intradermal tubular structures simply as an intradermal tubular component of SCAP. 8 As far as we can judge from the literature, sebaceous differentiation has not been previously described in the intradermal tubular component of SCAP.…”

Ectopic Tubular Papillary Apocrine Adenoma on the Eyelid: A Case Report of Misleading Clinical Presentation and Location

“…These apocrine glands were initially reported by – and named after the Dutch ophthalmolo gist – Jacob Moll (1832–1914), and Moll gland neoplasms are still considered to be clinically and pathologically a diagnostic challenge. A tubular apocrine adenoma (TAA) or tubular papillary adenoma (TPA) with apocrine differentiation describes a rare and benign sweat gland tumor, most commonly to be found as a nodular solitary lesion on the scalp and first described by Landry and Winkelmann in 1972 [2]. It is described to contribute to a common spectrum of different apocrine neoplasms with distinct architectural characteristics.…”