is how I am formally called, But I have many nicknames all over Brazil, Bicudo, Barbeiro, or Chupão, I am the famous bug. (...) (...) Places that I like to make my home Cracks in cob walls or unfinished furniture In every place that I arrive, I find my cozy spot And my offspring are raised." 1 THESE VERSES written by Brazilian poet P adua de Queiroz illustrate the burden of Chagas disease. The disease was described more than 100 years ago by Carlos Chagas, in Brazil, and remains a major social and public health problem in Latin America. 2 The World Health Organization considers Chagas a neglected tropical disease and claims that "it affects populations with low visibility and little political voice." 3 Chagas disease results from infection with a hemoflagellate protozoan parasite named Trypanosoma cruzi. Besides affecting the gastrointestinal tract, resulting in megaesophagus and megacolon, Chagas most frequently affects the heart (incidence of approximately 24%). 4 Chronic Chagas cardiomyopathy is a late manifestation, with up to a 30-year latency, and represents the most common cause of nonischemic cardiomyopathy in Latin America. 5,6 Four different pathophysiological mechanisms have been proposed to explain the cardiac manifestations of Chagas, including cardiac dysautonomia, microvascular disturbances, parasite-dependent myocardial damage, and immune-mediated myocardial injury. Those processes may result in cardiac arrhythmias, heart failure, aneurysms, and sudden death (60% of all deaths). 7 It can be challenging to diagnose and treat the disease, especially in nonendemic areas. Despite being considered a nonendemic area, the burden of Chagas in the United States is significant, and it is estimated that 300,000 infected immigrants reside in the United States, with 30,000 to 45,000 cases of Chagas cardiomyopathy. Most of those immigrants are originally from South America. 8