An Unusual Case of Galactorrhea With Normal Serum Prolactin

A case of normoprolactinemic galactorrhea following aneurysmal subarachnoid hemorrhage

“…A variant of prolactin that has high bioactivity especially on mammary tissue (as evidenced by galactorrhea) but lower immunoreactivity (poor recognition by immunoassay for prolactin) may account for galactorrhea with normal prolactin levels. [13,16,29] Intermittent hypersecretion of prolactin has been reported as a possible reason for normoprolactinemic galactorrhea [30,31] thus, it may be worth doing more than one prolactin level in a patient with unclear etiology of galactorrhea. Besides transient hyperprolactinemia, increased sensitivity of breast receptors to prolactin [29] may be responsible for the galactorrhea.…”

“…Obesity with eczema [13] , hypothyroid [14] Drugs GI: rabeprazole, domperidone [14,15] Psychiatric: duloxetine [16] , paroxetine [17] . quetiapine [18,19] , venlafaxine [20] , risperidonefluvoxamine combination [21] , ziprasidone [22] , escitalopram [23] , imipramine and escitalopram [24] Hormones: oral contraceptives [25] , depot medroxyprogesterone acetate [26] Miscellaneous chest wall surgery [27] , breast reduction surgery [6] , copper containing IUD [28] Hypothalamic pituitary gonadal axis may also play an important role in the development of normoprolactinemic galactorrhea.…”