An overview on the accumulation, distribution, transformations, toxicity and analytical methods for the monitoring of persistent organic pollutants

El-Shahawi, M.S.; Hamza, A.; Bashammakh, Abdulaziz S.; Alsaggaf, Wejdan T.

doi:10.1016/j.talanta.2009.09.055

Cited by 543 publications

(247 citation statements)

References 74 publications

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“…The present study showed that both p, p 0 -DDT and p, p 0 -DDE contributed to HCC in present subjects, who live in Xiamen, a city located at the center of the HCC high-risk regions in China. Interestingly, the heavy OCP use regions in China coincided with the high-HCC risk regions; historical use of OCPs in these areas accounted for 36.7% of the nationwide consumption (El-Shahawi et al, 2010). The data associating b-HCH exposure and liver cancers were more limited than DDT exposure.…”

Section: Association Of Ocp Exposure and Hccmentioning

confidence: 99%

“…Compared with Linxian, the southeastern coastline of China is characterized with a long monsoon season F the weather conditions that may increase human exposure to aflatoxins. In addition to HBV and AFB1, it is suspected that exposure to OCPs may also contribute to HCC incidence in the high-risk regions, where OCPs were once used much more heavily than the other areas in China (El-Shahawi et al, 2010) and still have limited production and usage (Qiu et al, 2005). Therefore, we designed a hospital-based casecontrol study to investigate the association between the incidence of HCC and exposure to OCPs by examining serum levels of hexachlorocyclohexane (Onishchenko et al, 2008) isomers (a-, b-, g-and d-HCH) and DDT and its derivatives (1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene: p, p 0 -DDE; 1,1,1-trichloro-2,2-bis (o-chlorophenyl) ethane: o, p 0 -DDT; 1,1-dichloro-2,2-bis (p-chlorophenyl) ethane: p, p 0 -DDD) in the Xiamen people who live in the middle of the southeastern coastline of China.…”

Section: Introductionmentioning

confidence: 99%

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Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: A case–control study

Zhao

Shen

Liu

et al. 2011

J Expo Sci Environ Epidemiol

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Primary hepatocellular carcinoma (HCC) is highly prevalent in China. Although hepatitis B virus (HBV) and aflatoxin B1 (AFB1) are considered the major risk factors, among the high-risk cohorts only a small fraction develops liver cancer. Therefore, we investigated if organochlorine pesticides (OCPs) exposure contributed to HCC risk in the Xiamen population. The questionnaire database was built from 346 HCC cases and 961 healthy controls during [2007][2008][2009]. The serum levels of a-, b-, g-, d-HCH, p, p 0 -DDT, p, p 0 -DDE, o, p 0 -DDT and p, p 0 -DDD were measured by gas chromatography-tandem mass spectrometer and statistical analysis was done using SPSS16. Significantly, we observed p, p 0 -DDT, p, p 0 -DDE, and at first time b-HCH displayed quartile dose-dependent HCC risk trends; p, p 0 -DDT showed positive (i.e., synergistic) interactions with HBV, diabetes mellitus, AFB1 and polycyclic aromatic hydrocarbon (PAH) exposure, but negative (i.e., antagonistic) interaction with heavy drinking; p, p 0 -DDE had positive interaction with PAH but negative interaction with HBV and p, p 0 -DDT; and b-HCH was positively interacted with p, p 0 -DDT but negatively interacted with heavy drinking and diabetes. p, p 0 -DDT, p, p 0 -DDE and b-HCH were independent HCC risk factors. Because of their synergistic interactions with other factors, the high level exposure combined with common AFB1 and HBV exposure in the investigated area may greatly enhance the risk of HCC.

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Section: Association Of Ocp Exposure and Hccmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: A case–control study

Zhao

Shen

Liu

et al. 2011

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

show abstract

“…The present study showed that both p,p 0 -DDT and p,p 0 -DDE contributed to HCC in present subjects, who live in Xiamen, a city located at the center of the HCC high-risk regions in China. Interestingly, the heavy-OCP-use regions in China coincided with the high HCC risk regions; historical use of OCPs in these areas accounted for 36.7% of the nationwide consumption (El-Shahawi et al, 2010). The data associating b-HCH exposure and liver cancers was more limited than DDT exposure.…”

Section: Association Of Ocp Exposure With Hccmentioning

confidence: 99%

“…Compared with Linxian, the southeastern coastline of China is characterized with a long monsoon season F the weather conditions that may increase human exposure to aflatoxins. In addition to HBV and AFB1, it is suspected that exposure to OCPs may also contribute to HCC incidence in the highrisk regions, where OCPs were once used much more heavily than the other areas in China (El-Shahawi et al, 2010) and still have limited production and usage (Qiu et al, 2005). Therefore, we designed a hospital-based case-control study to investigate the association between the incidence of HCC and exposure to OCPs by examining serum levels of hexachlorocyclohexane (Onishchenko et al, 2008) isomers (a-, b-, g-and d-HCH) and DDT and its derivatives (1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene (p,p 0 -DDE); 1,1,1-trichloro-2,2-bis (o-chlorophenyl) ethane (o,p 0 -DDT); and 1,1-dichloro-2,2-bis (p-chlorophenyl) ethane (p,p 0 -DDD)) in the Xiamen people who live in the middle of the southeastern coastline of China.…”

Section: Introductionmentioning

confidence: 99%

Exposure to organochlorine pesticides is an independent risk factor of hepatocellular carcinoma: A case–control study

Zhao

Shen

Liu

et al. 2011

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

Primary hepatocellular carcinoma (HCC) is highly prevalent in China. Although hepatitis B virus (HBV) and aflatoxin B1 (AFB1) are considered the major risk factors, among the high-risk cohorts only a small fraction develops liver cancer. Therefore, we investigated whether organochlorine pesticide exposure contributed to HCC risk in the Xiamen population. The questionnaire database was built from 346 HCC cases and 961 healthy controls during [2007][2008][2009]. The serum levels of a-, b-, g-, d-HCH, 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (p,p 0 -DDT), (1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene (p,p 0 -DDE), 1,1,1-trichloro-2,2-bis (o-chlorophenyl) ethane and 1,1-dichloro-2,2-bis (p-chlorophenyl) ethane were measured by gas chromatography-tandem mass spectrometer, and statistical analysis was done using SPSS16. Significantly, we observed p,p 0 -DDT and p,p 0 -DDE, and at the first time b-HCH displayed quartile dose-dependent HCC risk trends; p,p 0 -DDT showed positive (i.e., synergistic) interactions with HBV, diabetes mellitus, AFB1 and polyaromatic hydrocarbon (PAH) exposure, but negative (i.e., antagonistic) interaction with heavy drinking; p,p 0 -DDE had positive interaction with PAH but negative interaction with HBV and p,p 0 -DDT; and b-HCH positively interacted with p,p 0 -DDT but negatively interacted with heavy drinking and diabetes. p,p 0 -DDT, p,p 0 -DDE and b-HCH were independent HCC risk factors. Because of their synergistic interactions with other factors, the high-level exposure combined with common AFB1 and HBV exposure in the investigated area may greatly enhance the risk of HCC.

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“…These compounds can occur naturally but the largest amounts of PAHs released into the environment are due to anthropogenic processes related to the incomplete combustion of organic matter, by-products of industrial processing and cooking foods. PAHs have been identified as carcinogenic and mutagenic, as well as teratogenic [86]. The compound di(2-ethylhexyl)phthalate (DEHP) has also been included in this group.…”

Section: Hydrocarbonsmentioning

confidence: 99%

Electrochemical devices for the detection of priority pollutants listed in the EU water framework directive

Díaz‐González

Gutiérrez-Capitán

Niu

et al. 2016

TrAC Trends in Analytical Chemistry

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Monitoring chemical contamination in water is a must to guarantee the supply to the society of this more and more scarce prized asset. The European Union as well as other bodies have released reports and directives defining lists of substances whose detection in waters should be prioritized and posing limits to the maximum allowable concentrations that drinking water must have. The scientific community has been actively working on the development of analytical tools that could be applied in the detection of hazardous chemical species in waters. Here, an overview of electrochemical devices with the potential of being implemented to the monitoring of the forty five pollutants include in the list of priority substances set in the 2013 EU directive that could be grouped into heavy metals, pesticides, hydrocarbons, halogenated hydrocarbons and alkyl phenols, is given, aiming at showing their benefits and limitations in this scenario.

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An overview on the accumulation, distribution, transformations, toxicity and analytical methods for the monitoring of persistent organic pollutants

Cited by 543 publications

References 74 publications

Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: A case–control study

Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: A case–control study

Exposure to organochlorine pesticides is an independent risk factor of hepatocellular carcinoma: A case–control study

Electrochemical devices for the detection of priority pollutants listed in the EU water framework directive

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