An Overview on Medicinal Plants with Potential Antidepressant Activity

Shetty, Reshma A.

doi:10.22376/ijpbs/lpr.2020.10.5.l180-185

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Moreover, thiosemicarbazide molecules are used in new drug discovery [8] and for preparing several heterocycles [9,10]. They also show interesting biological properties, such as anticancer [8], antibacterial [11][12][13], antiviral [14,15] and antifungal [16] activities. The chemistry of lead is widely studied not only for its toxicity [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Aggregation of Lead(Ii) Perchlorate and a Thiosemicarbazide Derivative Linked by a Myriad of Non-Covalent Interactions

García‐Santos¹,

Castiñeiras²,

Mahmoudi

et al. 2022

SSRN Journal

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Section: Introductionmentioning

confidence: 99%

Supramolecular Aggregation of Lead(Ii) Perchlorate and a Thiosemicarbazide Derivative Linked by a Myriad of Non-Covalent Interactions

García‐Santos¹,

Castiñeiras²,

Mahmoudi

et al. 2022

SSRN Journal

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Analysis Of Anticancer Activity And Its Molecular Interaction Mechanism Of Withanone, An Active Ingredient Of Withania Somnifera Using Molecular Docking

Raj

Shankar²

2022

Int J Life Sci Pharm Res

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Withania somnifera is an annual evergreen shrub from the Solanaceae family, commonly known as Indian ginseng or Ashwagandha. The plant is mainly found in Asia and Africa regions. In the traditional Indian medicinal system ayurveda, Withania somnifera is used as a rejuvenator and sold in many countries as a dietary supplement. Withanolides are the major phytochemical constituent group found in the Withania somnifera, among which withaferin A and withanone, are considered to be major withanolides, which believed to be involved in majority of biological activity of Withania somnifera. Various studies including both in vitro and in vivo have reported regarding the anticancer potential of Withania somnifera. Along with the anticancer activity of W.somnifera, the anticancer efficacy of one of its major ingredients Withaferin A is also studied previously. This study aimed to analyse the anticancer potential of another major Withanolide present in W. Somnifera, Withanone. The study used Molecular Docking method to find the molecular binding affinity of Withanone towards various cancer proteins. The four major cancer proteins were B-cell lymphoma- extra large (Bcl-xL), Cellular FLICE (c-FLIP), Glutathione Reductase (GR) and Glutathione S- Transferases (GST). The protein structure obtained from the protein data bank and the structure of the molecule obtained from pubchem were modified and prepared for Docking studies with the help of MGL Tools. The protein ligand interaction study was conducted using the software, Autodock vina. The already known anticancer standard, 5-FluoroUracil is used as standard for comparison. Output obtained from the study is visualised using molecular visualiser tool, Pymol. Like the Withaferin A, Withanone also exhibited promising anticancer activity while studied using molecular docking methods.

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An Overview on Medicinal Plants with Potential Antidepressant Activity

Cited by 2 publications

References 29 publications

Supramolecular Aggregation of Lead(Ii) Perchlorate and a Thiosemicarbazide Derivative Linked by a Myriad of Non-Covalent Interactions

Supramolecular Aggregation of Lead(Ii) Perchlorate and a Thiosemicarbazide Derivative Linked by a Myriad of Non-Covalent Interactions

Analysis Of Anticancer Activity And Its Molecular Interaction Mechanism Of Withanone, An Active Ingredient Of Withania Somnifera Using Molecular Docking

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