An Overview of Novel Coronavirus SARS-Cov-2 Spanning around the Past, Present and Future Perspectives

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a new enveloped RNA virus known as Coronavirus (COVID-19) are most prevalent in humans and wild animals. All four species that is alpha, beta, delta and theta have been identified till date and are responsible for human disease; causing influenza like illness (ILI). This virus has similar lineage of Middle East Respiratory Syndrome coronavirus (MERS-CoV) and related Coronavirus (SARS-CoV). This outbreak initially presented as pneumonia-like illness in a group of people in Wuhan, China. The infection was said to be caused by seafood and unusual animals in the wholesale markets of this city. SARS-CoV-2 is highly infectious and has resulted in a rapid pandemic. As of now it has spread to 197 countries with total no of cases in the world being 3.76 million as of early march. The mortality till now is 7.11% .The cases have been increasing since its first discovery in China. In India also the number has been increased. Till now India has total of 39,980 cases and mortality is attributed to be 3.26%. As per data from Ministry of health and family welfare (MoHFW) death is more commonly seen in males with age >60years. Among these most of the deaths were related to other co-morbid conditions. This article will help the readers with an overview of novel Coronavirus spanning around the clinical features, diagnostic modalities, treatment strategies and infection control measures. It will also help in raising awareness among healthcare workers regarding COVID-19 and aid in early recognition of these patients. Moreover, this review will also focus on the most recent information for the effective management, prevention, and treatment of patients worldwide.

Computational Study of SARS-CoV-2 RNA Dependent RNA Polymerase Allosteric Site Inhibition

“…Then, in April 2012, a new CoV, called MERS-CoV, was reported to have infected people in the Middle East region [ 7 ], triggering severe acute respiratory syndrome in the infected patients [ 8 ]. SARS-CoV-2 is therefore a new CoV family member [ 9 ].…”

Resilience to the COVID-19 Pandemic: A Distributed Situation Awareness Perspective

“…In the absence of vaccines, controlling the spread of COVID-19 is essentially limited to hygienic practices of social distancing, face covering, isolation/quarantines, and contact tracing [4], [5]. Surprisingly, the few available controls over COVID-19 did not translate to a similar level of human and economic losses across countries, even when restricted to developed ones.…”