An Overview of Molecularly Imprinted Polymers Embedded with Quantum Dots and Their Implementation as an Alternative Approach for Extraction and Detection of Crocin

Abstract

Molecularly imprinting polymer (MIPs) is an emerging technology that could provide an alternative path to produce receptor-like binding sites. The technology involves complex bond formation between target molecules (templates), and functional monomers can occur insolvent. MIPS embedded with Quantum Dots (QDs) as a sensor is used for extraction and detection of various compounds. QDs have fluorescence properties and electronic characteristics such as comprehensive and continuous absorption spectra, narrow emission spectra, and high light resistance. Crocin is the major metabolite obtained from saffron (Crocus sativus). It is widely used as an antioxidant, antidiabetic, antitumor, and anticancer agent. According to recent studies, crocin has been used for drug delivery to treat various diseases. Therefore, the isolation, extraction and detection of crocin from saffron are of prime importance. Developing a selective extraction and detection technique for crocin would assist in its separation and purification easily from saffron stigmas. MIPs encapsulated with QDs is a promising tool for the extraction and detection of various compound, and this technique could also be employed for crocin. In this review, a brief summary of MIPs, QDs and MIP-QDs sensors has been summarised. Moreover, an effort has been made to review how MIPs encapsulated with QDs can be used as the best alternative for efficiently extracting and detecting crocin.

Molecularly Imprinted Polymeric Particles Created Using Droplet-Based Microfluidics: Preparation and Applications

“…Multi-step swelling is another approach that is also hampered by the competing solvent effect. This method consists of an initial stepwise, preformed seed-particle-swelling procedure followed by polymerization [27][28][29]. During the swelling procedure, an aqueous phase is required, which interferes with template moleculemonomer interactions.…”

An Overview on Recent Advances in Biomimetic Sensors for the Detection of Perfluoroalkyl Substances

“…Bulk free radical polymerization is the most common route to prepare MIPs for low-molecular-weight compounds such as PFAS, owing to its simplicity and low production costs for large amounts [ 100 ]. Once the polymerization is completed, the product is a solid polymeric structure that needs to be crushed, ground and then eluted with solvents.…”

Magnetic Molecularly Imprinted Polymers for Selective Separation Genistein from the Extract ofFlemingia philippinensisMerr. et Rolfe

“…Molecularly imprinted polymers (MIPs) have been widely synthesized by the polymerization reaction of functional monomers and cross‐linkers as new innovative sorbents by Molecular imprinting technology [25–27] . MIPs have attracted increasing attention because of low‐cost simple preparation, high selectivity, excellent adsorption performance, and excellent reusability.…”

“…Molecularly imprinted polymers (MIPs) have been widely synthesized by the polymerization reaction of functional monomers and cross-linkers as new innovative sorbents by Molecular imprinting technology. [25][26][27] MIPs have attracted increasing attention because of low-cost simple preparation, high selectivity, excellent adsorption performance, and excellent reusability. To date, MIPs was widely used in different fields, such as separation media in sample pretreatment, biological and environmental analysis, chemical and biomimetic sensors, and so on.…”