An Overview of Biomaterials in Periodontology and Implant Dentistry

Cho, Young‐Dan; Seol, Yang‐Jo; Lee, Yong-Moo; Rhyu, In‐Chul; Ryoo, Hyun‐Mo; Ku, Young

doi:10.1155/2017/1948241

Cited by 11 publications

(9 citation statements)

References 92 publications

(70 reference statements)

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“…The average surface roughness produced by the laser-treated acid-etched implant is around 2.28 μm. Studies have shown an increase in bone formation around such implant surfaces which lead to the formation of titanium nitride on the surface [8].…”

Section: Laser Treatmentsmentioning

confidence: 99%

Surface Matters Than the Implant Itself-a Review

Kannan¹,

Kurien²,

EJMS³

2024

Eastern J Med Sci

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Nowadays dental implants are a predictable and popular treatment option for tooth replacement in completely or partially edentulous patients. Implants are preferred over conventional treatment due to certain advantages it offers like preservation of bone; preservation of adjacent teeth, durability, better mastication and speech etc.Implant comes in direct bone contact and anchors through osseointegration. Successful osseointegration revolves around many factors such as biocompatibility of the implant material, quality and quantity of the available bone, surface treatment of the implant, loading and surgical protocol and various other systemic and local factors. Predictability of clinical success of dental implants can be enhanced by using newer materials or alterations in designs, surgical or loading protocols on the basis of available literature. Various studies have suggested that rough surface of implant enhances its integration with bone than a smooth implant surface. Several approaches are used to attain a rough surface and to improve the process of osseointegration of titanium dental implants. The present paper reviews different methods of treating implant surfaces to enhance bone implant interaction starting from the basic material used in dental implant manufacture. Key words: Osseointegration, Implant Surface Treatment,Titanium,Biomimetic.

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Section: Laser Treatmentsmentioning

confidence: 99%

Surface Matters Than the Implant Itself-a Review

Kannan¹,

Kurien²,

EJMS³

2024

Eastern J Med Sci

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“…Although guided tissue regeneration (GTR) promotes periodontal membrane reattachment and epithelial reconstruction [ 3 ], conventional GTR promotes neither the differentiation and maturation of osteoblasts nor the regeneration of alveolar bone. A controlled-release drug delivery system can prolong the time that drugs remain in the affected area, segment the administration of medications, and facilitate a timed, quantitative, and uniformly targeted treatment [ 4 ]. For example, bone morphogenetic protein-2 (BMP-2) hydrogels with chitosan (CS) have been found to induce new alveolar bone formation, promote jaw healing, and guide periodontal tissue regeneration [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Sequential anti-inflammatory and osteogenic effects of a dual drug delivery scaffold loaded with parthenolide and naringin in periodontitis

Chen

Wang

et al. 2023

J Periodontal Implant Sci

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Purpose Our pilot study showed that a 3-dimensional dual drug delivery scaffold (DDDS) loaded with Chinese herbs significantly increased the regenerated bone volume fraction. This study aimed to confirm the synergistic anti-inflammatory and osteogenic preclinical effects of this system. Methods The targets and pathways of parthenolide and naringin were predicted. Three cell models were used to assess the anti-inflammatory effects of parthenolide and the osteogenic effects of naringin. First, the distance between the cementoenamel junction and alveolar bone crest (CEJ-ABC) and the bone mineral density (BMD) of surgical defects were measured in a rat model of periodontitis with periodontal fenestration defects. Additionally, the mRNA expression levels of matrix metallopeptidase 9 (MMP9) and alkaline phosphatase (ALP) were measured. Furthermore, the number of inflammatory cells and osteoclasts, as well as the protein expression levels of tumor necrosis factor-alpha (TNF-α) and levels of ALP were determined. Results Target prediction suggested prostaglandin peroxidase synthase (PTGS2) as a potential target of parthenolide, while cytochrome P450 family 19 subfamily A1 (CYP19A1) and taste 2 receptor member 31 (TAS2R31) were potential targets of naringin. Parthenolide mainly targeted inflammation-related pathways, while naringin participated in steroid hormone synthesis and taste transduction. In vitro experiments revealed significant anti-inflammatory effects of parthenolide on RAW264.7 cells, and significant osteogenic effects of naringin on bone marrow mesenchymal stem cells and MC3T3-E1 cells. DDDS loaded with parthenolide and naringin decreased the CEJ-ABC distance and increased BMD and ALP levels in a time-dependent manner. Inflammation was significantly alleviated after 14 days of DDDS treatment. Additionally, after 56 days, the DDDS group exhibited the highest BMD and ALP levels. Conclusions DDDS loaded with parthenolide and naringin in a rat model achieved significant synergistic anti-inflammatory and osteogenic effects, providing powerful preclinical evidence.

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“…Currently, traditional bone allografts and alloplastic biomaterials used in dentistry have limited capacity to stimulate bone regeneration, and fundamentally act as osteoconductive materials. In addition, the need of treating alveolar bony defects with different shapes, sizes, and with limited anatomic accessibility has focused the interest in gel-state biomaterials [2,3]. Hydrogels consist of water-swollen nets of cross-linked polymer chains.…”

Section: Introductionmentioning

confidence: 99%

Preparation and osteogenic properties of nanocomposite hydrogel beads loaded with nanometric bioactive glass particles

Maureira¹,

Cuadra²,

Cádiz³

et al. 2021

Biomed. Mater.

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Bone reconstruction in the oral and maxillofacial region presents particular challenges related to the development of biomaterials with osteoinductive properties and suitable physical characteristics for their surgical use in irregular bony defects. In this work, the preparation and bioactivity of chitosan–gelatin (ChG) hydrogel beads loaded with either bioactive glass nanoparticles (nBG) or mesoporous bioactive glass nanospheres (nMBG) were studied. In vitro testing of the bionanocomposite beads was carried out in simulated body fluid, and through viability and osteogenic differentiation assays using dental pulp stem cells (DPSCs). In vivo bone regenerative properties of the biomaterials were assessed using a rat femoral defect model and compared with a traditional maxillary allograft (Puros®). ChG hydrogel beads containing homogeneously distributed BG nanoparticles promoted rapid bone—like apatite mineralization and induced the osteogenic differentiation of DPSCs in vitro. The bionanocomposite beads loaded with either nBG or nMBG also produced a greater bone tissue formation in vivo as compared to Puros® after 8 weeks of implantation. The osteoinductivity capacity of the bionanocomposite hydrogel beads coupled with their physical properties make them promissory for the reconstruction of irregular and less accessible maxillary bone defects.

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An Overview of Biomaterials in Periodontology and Implant Dentistry

Cited by 11 publications

References 92 publications

Surface Matters Than the Implant Itself-a Review

Surface Matters Than the Implant Itself-a Review

Sequential anti-inflammatory and osteogenic effects of a dual drug delivery scaffold loaded with parthenolide and naringin in periodontitis

Preparation and osteogenic properties of nanocomposite hydrogel beads loaded with nanometric bioactive glass particles

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