An ovarian cancer-associated antigen that crossreacts with a pregnancy-associated protein

Nakai, Mitsuo; Ohsawa, Yumiko; Nagata, Etsuko; Arai, Masao

doi:10.1016/0028-2243(87)90035-9

Cited by 8 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regard-250 KVRLE r-* ' REFERENCES ing the strong and long term protection afforded by each pregnancy, immunological change should also be considered as a possible explanation. An ovarian cancer-associated antigen that cross-reacts with a pregnancy-associated antigen has been described (Nakai et al, 1987), but the significance of this finding is not clear. Thus, we still lack a biological explanation that can adequately account for the apparent protection against ovarian cancer of high parity and use of oral contraceptives, but no consistent relationship with other reproductive factors.…”

Section: Resultsmentioning

confidence: 99%

Reproductive factors and risk of ovarian cancer: A prospective study

Kvåle

Heuch

Nilssen

et al. 1988

Intl Journal of Cancer

158

130

View full text Add to dashboard Cite

Associations between reproductive factors and risk of ovarian cancer were examined in a prospective study of 60,565 women in Norway. A total of 445 women were diagnosed as having ovarian cancer during follow-up, from 1961 through 1980. The highest risk was observed among nulliparous women, and the risk decreased significantly with increasing parity. The estimated odds ratio for women with 5 or more births compared with one birth was 0.46, after adjustment for age, urban/rural place of residence and occupational class. Neither age at first or last birth, nor age at menarche or menopause, nor marital status, showed significant associations with ovarian cancer risk after adjustment for parity. The apparent protective effect of high parity was observed for epithelial as well as non-epithelial cancers, and for the separate histological types of epithelial cancer except mucinous cystadenocarcinomas.

show abstract

Section: Resultsmentioning

confidence: 99%

Reproductive factors and risk of ovarian cancer: A prospective study

Kvåle

Heuch

Nilssen

et al. 1988

Intl Journal of Cancer

158

130

View full text Add to dashboard Cite

show abstract

“…Retrospectively, the protein was found to be cross-reactive with the antibody against the first generation protein; 94kDa-3-protein that was originally separated from the human placenta at term, and confirmed to be a candidate of a novel pregnancy-associated and tumour-related protein (Kami et aL, 1991;Nakai et aL, 1981Nakai et aL, , 1985Nakai et aL, , 1987aNakai et aL, , 1987bNakai et aL, , 1988Nakai et aL, , 1989.…”

mentioning

confidence: 99%

Cellular Characterization of the 91kDa-ectopic Ascitic Antigen Sharing Antigenicity with MRP8 in the Human Placenta as Revealed by Immunoelectron Microscopical Colloidal-gold Techniques

Sato

Morita

Ishiwata

et al. 1998

Okajimas Folia Anatomica Japonica

Self Cite

View full text Add to dashboard Cite

Summary: Cellular characterization of the 91kDa-ectopic ascitic protein that exhibits pregnancy-associated and tumourrelated dynamics has been examined in the human placenta using an electron microscopic immunocolloidal-gold technique. This protein was initially isolated from the ascitic fluids of a patient suffered from ovarian and uterine cancers with mixed mesodermal tumours, and determined to be sharing antigenicity with the 28kDa-oncodevelopmental protein and a calcium-binding protein; MRP8/CFA, respectively. Placentas obtained were divided into three groups by their gestational periods. Small chorionic villous tissues were embedded in Lowicryl K4M resin or Epon 812 resin. Specific and higher labellings by gold-particles were obtained in sections of Lowicryl resin and, then, recognized in mesenchyme-derived cells and/or myeloid lineages; such as placental tissue macrophages (Hofbauer cells), fibroblasts, foetal myelomonocytic cells including endothelial cells, etc., in the first and second trimesters. So far, the pattern of antigenic appearances changed depending on the stage of gestation. On the other hand, 91kDa-protein was also determined in the syncytiotrohpoblast, but not in cytotrophoblasts at whenever been examined. It is assumed that the antigenic expression in syncytiotrophoblasts might be reflected to be absorbed or incorporated from those of foetal or maternal origins, and the antibody used in this study should be sensitive to the antigenic epitope derived from those of myeloid lineages. In the light of these results, hypotheses concerning mechanisms of both transplacental permeability of substances by the placental barrier and cell/tissue differentiation by calcium-binding (and/or -depending) proteins such as 91kDa-protein, MRP8, etc.; presumable the S-100 protein family, are discussed further.

show abstract

Quantitative analysis of a novel pregnancy-associated protein in trophoblastic diseases, normal pregnancy and healthy female subjects

Nakai

Atsumi

Odagiri

et al. 1988

Arch Gynecol Obstet

View full text Add to dashboard Cite

By means of the Laurell rocket technique, a novel pregnancy-associated protein was measured in the serum of patients with trophoblastic diseases as well as in pregnant women. In 52 normally-menstruating women, the serum levels were below the detection limit in 40 (76.9%); 50 women (96.2%) had levels of less than 2.0 U/ml, and none had levels above 2.1 U/ml. Of 25 patients with a hydatidiform mole, 23 (92.0%) had elevated levels (greater than 2.2 U/ml). In 84 healthy pregnant women, the levels rose from being undetectable before 5 weeks to a plateau in the second trimester. The results suggest that the appearance of this protein in serum is associated with trophoblastic activity.

show abstract

An ovarian cancer-associated antigen that crossreacts with a pregnancy-associated protein

Cited by 8 publications

References 9 publications

Reproductive factors and risk of ovarian cancer: A prospective study

Reproductive factors and risk of ovarian cancer: A prospective study

Cellular Characterization of the 91kDa-ectopic Ascitic Antigen Sharing Antigenicity with MRP8 in the Human Placenta as Revealed by Immunoelectron Microscopical Colloidal-gold Techniques

Quantitative analysis of a novel pregnancy-associated protein in trophoblastic diseases, normal pregnancy and healthy female subjects

Contact Info

Product

Resources

About