An Outbreak of Mayaro Virus Disease in Belterra, Brazil

Pinheiro, F. P.; Freitas, Ronaldo Barros de; Rosa, J. F. Travassos da; Gabbay, Yvone Benchimol; Mello, Wyller Alencar de; LeDuc, James W.

doi:10.4269/ajtmh.1981.30.674

Cited by 137 publications

(123 citation statements)

References 0 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…Since 1955, when the first case of MAYV infection was reported in Brazil, near the Guamá River in Pará State (Causey and Maroja 1957), several MAYV fever outbreaks have been reported in different Brazilian States, including Pará (Pinheiro et al 1981, Azevedo et al 2009), Amazonas (De Figueiredo et al 2004, Abad-Franch et al 2012, Mourão et al 2012, Acre (Tavares-Neto et al 2004, Silva-Nunes et al 2006 and Mato Grosso (Zuchi et al 2014). Most of the cases were described in rural regions, in which MAYV seems to be transmitted by Haemagogus spp.…”

mentioning

confidence: 99%

“…The illness begins with an undifferentiated fever, headache, retro-orbital pain, rash and vomiting with 2 to 5 days of duration and a short period of viremia (Pinheiro et al 1981). Muscle and articular pain reaches several joints, persisting for weeks or months (Hassing et al 2010, Receveur et al 2010, Theilacker et al 2013, Slegers et al 2014) with small joints preferentially affected (Friedrich-Jänicke et al 2014).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Macrophages as target cells for Mayaro virus infection: involvement of reactive oxygen species in the inflammatory response during virus replication

Cavalheiro

Costa

Campos

et al. 2016

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

Alphaviruses among the viruses that cause arthritis, consisting in a public health problem worldwide by causing localized outbreaks, as well as large epidemics in humans. Interestingly, while the Old World alphaviruses are arthritogenic, the New World alphaviruses cause encephalitis. One exception is Mayaro virus (MAYV), which circulates exclusively in South America but causes arthralgia and is phylogenetically related to the Old World alphaviruses. Although MAYV-induced arthritis in humans is well documented, the molecular and cellular factors that contribute to its pathogenesis are completely unknown. In this study, we demonstrated for the first time that macrophages, key players in arthritis development, are target cells for MAYV infection, which leads to cell death through apoptosis. We showed that MAYV replication in macrophage induced the expression of TNF, a cytokine that would contribute to pathogenesis of MAYV fever, since TNF promotes an inflammatory profile characteristic of arthritis. We also found a significant increase in the production of reactive oxygen species (ROS) at early times of infection, which coincides with the peak of virus replication and precedes TNF secretion. Treatment of the cells with antioxidant agents just after infection completely abolished TNF secretion, indicating an involvement of ROS in inflammation induced during MAYV infection.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Macrophages as target cells for Mayaro virus infection: involvement of reactive oxygen species in the inflammatory response during virus replication

Cavalheiro

Costa

Campos

et al. 2016

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

show abstract

“…This maintenance cycle is similar to that of sylvatic yellow fever (YFV), and the places that suffer MAYV outbreaks could also have outbreaks of YFV, which occurred in the City of Santa Cruz de la Sierra, Bolivia, in the 1980s 12,35 . A study of 335 blood samples of indigenous communities in the Rio Negro region, Brazil, indicated that 41.5% of those tested had antibodies against MAYV, which demonstrates that it is a common infection in this region 5 by an enzyme immunoassay in the sera of 33 patients aged 6 to 65 years.…”

Section: Mayaro Virusmentioning

confidence: 99%

“…This mutation resulted in the spread of CHIKV into the Indian Ocean and Asia, which produced a large epidemic. In contrast, MAYV is an arbovirus transmitted by Haemagogus mosquitoes that feed on primates that live in tree canopies 12 . This virus causes sporadic cases or outbreaks of febrile illness in the Amazon region, including large cities, such as Manaus 13 .…”

Section: Figueiredo Mlg and Figueiredo Ltm -Emerging Alphaviruses In mentioning

confidence: 99%

See 1 more Smart Citation

Emerging alphaviruses in the Americas: Chikungunya and Mayaro

Figueiredo

2014

Rev. Soc. Bras. Med. Trop.

116

View full text Add to dashboard Cite

Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are emergent arthropod-borne viruses that produce outbreaks of acute febrile illness with arthropathy. Despite their different continental origins, CHIKV and MAYV are closely related and are components of the Semliki Forest Complex of the Alphavirus (Togaviridae). MAYV and, more recently, CHIKV, which are both transmitted by Aedes mosquitoes, have resulted in severe public health problems in the Americas, including Brazil. In this review, we present aspects of the pathogenesis, clinical presentation and treatment of febrile illnesses produced by CHIKV and MAYV. We also discuss the epidemiological aspects and effects related to the prophylaxis of infections by both viruses.

show abstract

Clinical and laboratory diagnosis of Mayaro virus (MAYV): Current status and opportunities for further development

da Silva,

Krokovsky

2024

Reviews in Medical Virology

View full text Add to dashboard Cite

The recent outbreaks related to Mayaro virus (MAYV) infection in the Americas have brought this neglected virus as a potential threat to global public health. Given the range of symptoms that can be associated with MAYV infection, it can be challenging to diagnose individuals based on clinical signs, especially in countries with simultaneous circulation of other mosquito‐borne viruses, such as dengue virus (DENV) and chikungunya virus (CHIKV). With this challenge in mind, laboratory‐based diagnosis assumes a critical role in the introduction of measures to help prevent virus dissemination and to adequately treat patients. In this review, we provide an overview of the clinical features reported in infected patients and currently available laboratory tools that are used for MAYV diagnosis, discussing their advances, advantages, and limitations to apply in the field. Moreover, we explore novel point‐of‐care (PoC) diagnostic platforms that can provide de‐centralised diagnostics for use in areas with limited laboratory infrastructure.

show abstract

An Outbreak of Mayaro Virus Disease in Belterra, Brazil

Cited by 137 publications

References 0 publications

Macrophages as target cells for Mayaro virus infection: involvement of reactive oxygen species in the inflammatory response during virus replication

Macrophages as target cells for Mayaro virus infection: involvement of reactive oxygen species in the inflammatory response during virus replication

Emerging alphaviruses in the Americas: Chikungunya and Mayaro

Clinical and laboratory diagnosis of Mayaro virus (MAYV): Current status and opportunities for further development

Contact Info

Product

Resources

About