An Outbreak of Community-Acquired Pneumocystis Carinii Pneumonia. Initial Manifestation of Cellular Immune Dysfunction

Masur, Henry; Michelis, Michael F.; Greene, JeffreyB.; Onorato, Ida M.; Stouwe, Robert A. Vande; Holzman, Robert S.; Wormser, Gary P.; Brettman, Lee R.; Lange, Michael; Murray, Helen; Cunningham‐Rundles, Susanna

doi:10.1016/s0022-5347(17)52960-2

Cited by 171 publications

(222 citation statements)

References 0 publications

Supporting

Mentioning

190

Contrasting

Unclassified

Order By: Relevance

“…Bacterial pneumonia, which is more common in HIV-infected individuals, has contributed to this rise. At our hospital the first case of AIDS was diagnosed in late 1984.There is therefore a lag time of about four years for AIDS cases, compared with large cities such as San Francisco and New York [36]. This explains our low incidence of AIDS-related diseases and, particularly, the lack of infections with atypical mycobacteria that commonly appear late in the evolution of HIV infection [37].…”

Section: Discussionmentioning

confidence: 96%

Infectious Complications in Drug Addicts: Seven-Year Review of 269 Hospitalized Narcotics Abusers in Switzerland

Scheidegger

Zimmerli

1989

Clinical Infectious Diseases

View full text Add to dashboard Cite

In a retrospective survey of patients hospitalized in the Department of Medicine of the University Hospital, Basel, Switzerland, from 1980to 1986, we found 269 patients with history of past or current drug abuse. The charts of these patients were analyzed for infectious complications according to defined criteria. Heroin was the principal drug consumed by 95010. In 127patients (47010) at least one infectious complication was diagnosed. In 125(31010) of 404 admissions, the infectious problem was the main reason for hospitalization. Among the 269 patients, 217 infective episodes occurred. Pulmonary infections were the most frequently occurring (52 episodes). There were 44 cases of viral hepatitis, 30 of human immunodeficiency virus infection, and 25 of minor genital infections. Bone and joint infections and sepsis/endocarditis werediagnosed in seven cases each. The overall mortality was 4.1070; however, only three of the 11 deaths were attributed to infections. Intravenous drug addiction is complicated by a high morbidity because of infections that were seldom lethal during the observed period.Intravenous drug addicts are a population at risk for infectious complications such as bacteremia, fungemia, endocarditis, pneumonia, arthritis, osteomyelitis, septic thrombophlebitis, soft tissue infections, venereal diseases, viral hepatitis, and infections with the human immunodeficiency virus (HIV) . Between the 1940s and the 1970s, several publications covered the whole spectrum of infections [23][24][25][26][27][28][29], whereas in the recent literature, more attention has been given to single infections in narcotics abusers . The present report describes all infectious complications among drug addicts that have been diagnosed at the medical department of the Basel University Hospital (Basel, Switzerland) between 1980 and 1986. The frequencies and etiologies of the particular infections are presented and compared with those described in the literature.

show abstract

Section: Discussionmentioning

confidence: 96%

Infectious Complications in Drug Addicts: Seven-Year Review of 269 Hospitalized Narcotics Abusers in Switzerland

Scheidegger

Zimmerli

1989

Clinical Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…El VIH-sida es causado por el virus de la inmunodeficiencia humana (VIH); en 1981 se conoció por primera vez esta enfermedad en una epidemia que se inició en San Francisco, Estados Unidos; en 1983 se aisló el virus por primera vez y en 1984 se demostró claramente que dicho virus era el causante de la infección (1,2).…”

unclassified

“…El VIH se une selectivamente a las células que expresan en su superficie el receptor CD4; las más importantes son los linfocitos T ayudadores y las células del sistema monocítico mononuclear. De esta forma, ocasiona un daño serio e irreversible en las funciones de la inmunidad celular y en el control de la inmunidad humoral, lo cual ocasiona deficiencia progresiva del sistema inmunitario de la persona infectada (2).…”

unclassified

Patrones de prescripción de antirretrovirales en 997 pacientes colombianos

Machado

Alzate

2008

biomedica

View full text Add to dashboard Cite

Introducción. El tratamiento antirretroviral de la infección por virus de inmunodeficiencia humana ha mejorado la supervivencia y la calidad de vida de los pacientes desde el advenimiento de la terapia combinada en 1996. Objetivos. Conocer el manejo farmacológico de la infección por VIH/sida. Materiales y métodos. Estudio descriptivo observacional con selección de pacientes con infección por VIH/sida, de ambos sexos, de todas las edades, en tratamiento, al menos, durante tres meses (julio a septiembre de 2006) localizados en diferentes ciudades colombianas y afiliados al Sistema General de Seguridad Social en Salud. Se diseñó una base de datos con registros sobre el consumo de medicamentos antirretrovirales, recolectados por la empresa que dispensa dichos fármacos a los pacientes de las entidades promotoras de salud. Resultados. Se estudiaron 997 pacientes con edad promedio de 37,7±13,2 años, 82,6% de hombres. Todos los pacientes recibían terapia con tres o más antirretrovirales; el orden de prescripción de medicamentos fue: inhibidores de nucleósidos de transcriptasa inversa (96,4%), inhibidores de transcriptasa inversa no nucleósidos (54,9%), inhibidores de proteasa (39,8%) y otros (0,4%), todos a dosis adecuadas. Las combinaciones más empleadas fueron: lamivudina-zidovudina-efavirenz (35%), lamivudina-zidovudina con lopinavir/ritonavir (8,4%), abacavir con lamivudina-zidovudina (5,5%), lamivudina-zidovudina con nevirapina (5,2 %) y otras 65 asociaciones diferentes (45,9%). Conclusiones. Todos los antirretrovirales se están utilizando a las dosis establecidas internacionalmente y predominan patrones de prescripción racionales para iniciar la terapia. Sin embargo, el encontrar 69 asociaciones diferentes de antirretrovirales lleva a considerar que no hay adecuados criterios para la implementación de los esquemas después del inicio del tratamiento, guiados según los datos científicos y quienes los prescriben adoptan múltiples opciones por fuera de lo recomendado a nivel mundial.Palabras clave: síndrome de inmunodeficiencia adquirida/terapia, terapia antirretroviral altamente activa, prescripción de medicamentos, Colombia. Patterns of antiretroviral drug prescripcion in 997 Colombian patientsIntroduction. Antiretroviral therapy for treatment of human immunodeficiency virus type 1 (HIV-1) infection has improved steadily since the advent of combination therapy in 1996. Objective. The pharmacological therapies of the infection by HIV/AIDS were documented in order to determine if effective treatment regimes were prescribed. Materials and methods. Pharmacological therapies of the human immunodeficiency virus infection were compared in 997 patients affiliated with the health security system, of both sexes and all ages. All had been in treatment for more than three months (July-September 2006) and were distributed in 15 Colombian cities. The data were retrieved from medication consumption files which were maintained by the institutions that had distributed medications to the selected patients. Results. The average age of...

show abstract

“…Jaffe and McMahon-Pratt (1983) first indicated in their Epidemiological studies conducted in 1981 and 1982 that the major channel of transmission of AIDS were intimate sexual contact and contaminated blood. Gottlieb et al (1981); Masur et al (1981); Siegal et al (1981); Callazos et al (2010); van…”

Section: Portals Of Hiv Transmissionmentioning

confidence: 99%

Human Immunodeficiency Virus Transmission

Nanjul¹

2011

Global View of HIV Infection

View full text Add to dashboard Cite

An Outbreak of Community-Acquired Pneumocystis Carinii Pneumonia. Initial Manifestation of Cellular Immune Dysfunction

Cited by 171 publications

References 0 publications

Infectious Complications in Drug Addicts: Seven-Year Review of 269 Hospitalized Narcotics Abusers in Switzerland

Infectious Complications in Drug Addicts: Seven-Year Review of 269 Hospitalized Narcotics Abusers in Switzerland

Patrones de prescripción de antirretrovirales en 997 pacientes colombianos

Human Immunodeficiency Virus Transmission

Contact Info

Product

Resources

About