An oral cancer biobank initiative: a platform for multidisciplinary research in a developing country

Abstract

Identification of diagnostic markers for early detection and development of novel and therapeutic agents for effective patient management are the main motivation for cancer research. Biological specimens from large cohort and case-control studies which are crucial in providing successful research outcomes are often the limiting factor that hinders research efforts, especially in developing countries. Therefore, the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS) were established to systematically collect large number of samples with comprehensive sociodemographic, clinicopathological, management strategies, quality of life and associated patient follow-up data to facilitate oral cancer research in Malaysia. The MOCDTBS also promotes sharing among researchers and the development of a multidisciplinary research team. The following article aims to describe the process of setting-up and managing the MOCDTBS.

Caveolin 1 (Cav-1) and actin-related protein 2/3 complex, subunit 1B (ARPC1B) expressions as prognostic indicators for oral squamous cell carcinoma (OSCC)

“…Normal oral mucosal tissues included alveolar mucosal tissues obtained from minor surgical procedure of impacted wisdom teeth. Socio-demographic, clinico-pathological, and survival data of all OSCC samples were obtained from the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS) coordinated by the Oral Cancer Research and Coordinating Centre, University of Malaya (OCRCC-UM) [19]. The American Joint Committee on cancer staging criteria was used for tumor staging [20].…”

Biobanks in Oral Health: Promises and Implications of Post-Neoliberal Science and Innovation

“…A PubMed search with keywords ''biobank'' and ''dentistry'' cites the article of Galloway (2011) as the oldest in the field, wherein he describes the UK Biobank project. Since then, there have been successful attempts to collect and organize human oral samples systemically in developed and developing countries; for example, Norwegian primary teeth biobank (Tvinnereim et al, 2012), Malaysian oral cancer biobank (Zain et al, 2013), and Malaysian periodontal disease and biobank system (Vaithilingam et al, 2015). There are, of course, other biobanks, such as UK Biobank (http:// www.ukbiobank.ac.uk) or the Finnish Biobank (http:// www.nationalbiobanks.fi/), where the aim is to collect several different human samples, including oral samples, such as saliva, from population cohorts.…”

Avaliação do impacto da implantação do controle de qualidade em um banco de amostras teciduais criopreservadas

“…A identificação d e marcado res de d iagnóstico p ara d etecção pre coce e o desenvolvimento de no vos a gentes te rapêuticos que serão ef icazes ao pacie nte é a principal motivação par a a pesquisa e m cânce r. No entanto, as l imitações de amostras disponíveis d ificultam a t radução bem s ucedida de resultados da investigação para a prática clínica. Para superar essas limitações existe a necessidade de criar bancos de tumores de qualidade, que irão organizar a coleta de amostras e de seus dados clínicos de maneira satisfatória Dougall, 2011;Zain et al, 2012). Ambrosone et al, 2006;.…”

“…A a usência desses materiais co ndena o estudo de sde o início, enquanto q ue a sua p resença g arante a matéria-prima es sencial e ap ropriada pa ra responder às questões c ientíficas (Dhir, 2008 Balaguer et al, 2006;Ruiz-Godoy et al, 2010;Zain et al, 2012).…”

“…Tão impor tante quanto g arantir a rastreabilidade c ompleta da coleta, do processamento e do a rmazenamento d a amo stra é a o btenção de dados clínicos de qualidade, já que eles são fundamentais para o desenvolvimento da pesquisa , 2008;Hwang et al, 2008;Zain et al, 2012).…”