An open pilot study of ambulatory photodynamic therapy using a wearable low-irradiance organic light-emitting diode light source in the treatment of nonmelanoma skin cancer

Attili, Sasi Kiran; Lesar, Andrea; McNeill, Andrew; Camacho-López, Miguel A.; Moseley, Harry; Ibbotson, S.H.; Samuel, Ifor D. W.; Ferguson, J.

doi:10.1111/j.1365-2133.2009.09096.x

Cited by 138 publications

(108 citation statements)

References 11 publications

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“…84,85 A recent open study of ambulatory PDT in NMSC included 30 patients with SCC in situ, with an overall 84% lesion response reported at 1 year (including 10 SCCs in situ with followup). 86 Red narrowband LED light is used most often; however, a square wave intense pulsed light, with reduced dose variability, cleared all nine SCCs in situ in one case series, with all lesions remaining clear after a follow-up period of 4 months.…”

mentioning

confidence: 99%

BritishAssociation ofDermatologists' guidelines for the management of squamous cell carcinomain situ(Bowen's disease) 2014

et al. 2014

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mentioning

confidence: 99%

BritishAssociation ofDermatologists' guidelines for the management of squamous cell carcinomain situ(Bowen's disease) 2014

et al. 2014

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“…There are only a few reports using conventional OLEDs in close contact with biological matter [181]. OLED are mostly used as wearable light sources [182][183][184] and have not been implanted into tissue. Therefore, there is a need for completely biocompatible and possibly biodegradable LEDs: bio-OLEDs.…”

Section: Biomaterials Based Ledsmentioning

confidence: 99%

Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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“…However, LEDs do not emit the same light dose over the entire treatment area and do not adapt to the irregularities of the body [13,18]. Another disadvantage of this method is pain due to the dose of pure light that effective treatment with LED panels [19,20]. Indeed, if the light output was less, we could limit the pain caused by the PDT.…”

Section: Introductionmentioning

confidence: 99%

Light-Emitting Woven Fabric for Treatment with Photodynamic Therapy and Monitoring of Actinic Keratosis

Oguz¹,

Končar²,

Cochrane³

et al. 2017

Photomedicine - Advances in Clinical Practice

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A successful photodynamic therapy (PDT) requires a specific photosensitizer, oxygen and light of a specific wavelength and power. Today photodynamic therapy (PDT) is administered to patients with light-emitting diode (LED) panels. These panels deliver a non-uniform light distribution on the human body parts, as the complex human anatomy is not a flat surface (head vertex, hand, shoulder, etc.). For an efficient photodynamic therapy (PDT), a light-emitting fabric (LEF) was woven from plastic optical fibers (POF) aiming at the treatment of dermatologic diseases such as actinic keratosis (AK). Plastic optical fibers (POF) (Toray, PGR-FB250) have been woven in textile in order to create macro-bendings, and thus emit out the injected light directly to the skin. The light intensity and light-emitting homogeneity of the LEF were improved thanks to Doehlert Experimental Design. During the treatment with PDT, the photosensitizers were activated in the cancerous cells. These cells may be visualized, as they show a characteristic fluorescence under UV light, which is called fluorescence diagnosis (FD). Therefore, it is proposed to modify the developed LEF for PDT to measure the fluorescence amount. For this aim, a part of POFs was cut out to observe the quantity of light that could be collected while the LEF was connected to a light source. The first prototypes showed the possibility of the illumination with the same LEF without losing the efficiency but also imaging the collected light.

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An open pilot study of ambulatory photodynamic therapy using a wearable low-irradiance organic light-emitting diode light source in the treatment of nonmelanoma skin cancer

Cited by 138 publications

References 11 publications

BritishAssociation ofDermatologists' guidelines for the management of squamous cell carcinomain situ(Bowen's disease) 2014

BritishAssociation ofDermatologists' guidelines for the management of squamous cell carcinomain situ(Bowen's disease) 2014

Toward biomaterial-based implantable photonic devices

Light-Emitting Woven Fabric for Treatment with Photodynamic Therapy and Monitoring of Actinic Keratosis

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