An MR-compatible antenna and application in a murine superficial hyperthermia applicator

Abstract

In this work, a novel magnetic resonance (MR)-compatible microwave antenna was designed and validated in a small animal superficial hyperthermia applicator. The antenna operates at 2.45 GHz and matching is made robust against production and setup inaccuracies. To validate our theoretical concept, a prototype of the applicator was manufactured and tested for its properties concerning input reflection, sensitivity for setup inaccuracies, environment temperature stability and MR-compatibility. The experiments show that the applicator indeed fulfils the requirements for MR-guided hyperthermia investigation in small animals: it creates a small heating focus (<1 cm), has a stable and reliable performance (S< -15 dB) for all working conditions and is MR-compatible.

Efficacy and Safety Evaluation of the Various Therapeutic Options in Locally Advanced Cervix Cancer: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials

“…[103][104][105][106][107]113,114,116 These actions, coupled with the technological advancements in HT delivery, planning, online thermometry, and adaptive temperature modulation, should encourage integration of HT with RT and/or CT not only in LACC but also in other sites. 105,[108][109][110][111][112][117][118][119][120][121]129 It is noteworthy that 3 modal-itiesdHTRT, HTCTRT, and CTRT(3wkly Pt)dmaintained their superiority in terms of safety and efficacy in LACC, even after the sensitivity analysis for all trials published during or after 2004. The outcomes of the 2 ongoing multicentric-randomized trials in LACCdnamely, OUTBACK 130 and INTERLACE 131 daddressing NACT þ CTRT(wkly Pt) versus CTRT(wkly Pt) and CTRT(wkly Pt) þ ACT versus CTRT(wkly Pt), respectively, would be of considerable interest.…”

“…The technological advances in hardware and software over the last decade have led to safer locoregional HT delivery, thermal treatment planning, thermal dose monitoring through noninvasive thermometry, and online adaptive temperature modulation. 105,[117][118][119][120][121] Temperature monitoring during HT in cervix cancer and the adjacent normal organs of bladder and rectum can be performed effectively through noninvasive temperature sensors. Effectiveness of HTRT over RT was also reported in an earlier pairwise meta-analysis in LACC.…”

External Basic Hyperthermia Devices for Preclinical Studies in Small Animals

“…Other types of electromagnetic heating, such as radiofrequency and microwave, have also been employed for preclinical hyperthermia studies [ 37 , 152 , 153 ]. Radiofrequency-based hyperthermia (3 Hz to 300 MHz) is most frequently used for deep-seated tumors, while microwave heating (300 MHz to 300 GHz) is suitable for treatment of superficial malignancies [ 154 ].…”

Systematic review of pre-clinical and clinical devices for magnetic resonance-guided radiofrequency hyperthermia

“…-The Yagi-Uda-based small animal HT applicator operating at 2.45 GHz was designed and validated by Raaijmakers et al (2018) for superficial HT in small animals in a 7 T MR scanner [70]. The antenna was based on an earlier designed MR-compatible Yagi-Uda antenna presented by Paulides et al (2017) [71].…”