An isoindoline bridged [M(η⁶-arene)₂]⁺ (M = Re, ^99mTc) ansa-arenophane and its dinuclear macrocycles with axial chirality

Abstract

This work presents a straightforward method for the preparation of an isoindoline bridged [M(arene)2]+ (M = Re, 99mTc) ansa-[3]arenophane. This intramolecular formation of an ansa-complex is accompanied by the intermolecular...

In vivo and in vitro studies of [M(η6-pseudoerlotinib)2]+ sandwich complexes (M = Re, 99mTc)

“…[Re(η 6 -(aniline) 2 )] PF 6 and L1 were synthesized according to a literature procedure. 24,25 Fig. 8 Biodistribution data expressed as % ID per g organ for [ 99m Tc]1 at 1 and 4 h after administration in CD-1 mice (n = 3).…”

“…To selectively synthesize the complex with the rhenium sandwiched by the aniline rings, we started from [Re(η 6 -aniline) 2 ] + . 22,24 Conjugation of the fragment L1 (see Scheme 2) would give a 'pseudoerlotinib' rhenium sandwich through a two steps reaction: (i) synthesis of [Re(η 6 -aniline) 2 ] + ; (ii) nucleophilic aromatic substitution to form [Re(η 6 -pseudoerlotinib) 2 ] + , thereby modifying a procedure reported in literature for the synthesis of the free erlotinib. 25 [Re(η 6 -aniline) 2 ] + was prepared by exchange of naphthalene with aniline in [Re(η 6 -napht) 2 ] + .…”

“…25 [Re(η 6 -aniline) 2 ] + was prepared by exchange of naphthalene with aniline in [Re(η 6 -napht) 2 ] + . 24 [Re(η 6 -aniline) 2 ] + was then reacted with L1 in 0.5 M HCl solution at 70 °C for 24 h, forming [Re(η 6 -pseudoerlotinib) 2 ] + (1) in 77% yield (Scheme 2). The 1 H NMR spectrum of 1 in acetone-d 6 displays three resonances for the aniline ring at 7.30 (H o ), 6.19 (H m ) and 5.87 (H p ) ppm respectively, which are upfield shifted as compared to the signals of the [Re(η 6 -aniline) 2 ] + .…”

Reactivities of [Re(η6-C6H6)(η6-C10H8)]+ and [Re(η6-C10H8)2]+ with Cyclic, Nonaromatic Polyenes

“…Unless otherwise stated, all chemicals were of reagent grade or higher, obtained from commercial sources and used without further purification. [Re­(η 6 -C 10 H 8 ) 2 ] + ( 2 ) and the ligands cyclohepta-3,5-dien-1-ol and cycloocta-1,3,5-triene were synthesize according literature procedures. ,, Solvents for reactions were of p.a. grade or distilled prior to their use; H 2 O was bidistilled.…”