An Intravitreal Sustained-Release Triamcinolone and 5-Fluorouracil Codrug in the Treatment of Experimental Proliferative Vitreoretinopathy

Safety of an Intravitreal Injection of Triamcinolone

“…These include embolic retinal artery occlusion and accidental penetration or perforation of the globe. [16][17][18][19] The findings from our study neither advocate nor support the use of intravitreal corticosteroids for the treatment of retinal neovascularization or any other condition. Intravitreal triamcinolone has been studied in animals for retinal neovascularization and proliferative vitreoretinopathy.…”

Safety of an Intravitreal Injection of Triamcinolone

“…These include embolic retinal artery occlusion and accidental penetration or perforation of the globe. [16][17][18][19] The findings from our study neither advocate nor support the use of intravitreal corticosteroids for the treatment of retinal neovascularization or any other condition. Intravitreal triamcinolone has been studied in animals for retinal neovascularization and proliferative vitreoretinopathy.…”

Pharmacokinetics of intravitreal 5‐fluorouracil prodrugs in silicone oil: experimental studies in pigs

“…From previously published data concerning the 5-FU clearance from vitrectomized rabbit vitreous, it can be calculated that with a sustained intravitreal concentration of 50 mg/ml, the entire amount of injected 5-FU would be exhausted in less than 18 days (Jarus et al 1985). However, concentrations above 50 mg/ml were maintained for more than 42 days, and concentrations above 10 mg/ml were maintained for more than 84 days with this codrug (Yang et al 1998).…”

Immunohistochemical characterization of sub retinalmembranes (SRMs) in proliferative vitreoretinopathy

“…19,23 Low dose intra vitreal triamcinolone, anti-proliferative and anti-neoplastic medications have shown some benefit in PVR if combined with surgery. 24…”

Safety of an Intravitreal Injection of Triamcinolone

“…These include embolic retinal artery occlusion and accidental penetration or perforation of the globe. [16][17][18][19] The findings from our study neither advocate nor support the use of intravitreal corticosteroids for the treatment of retinal neovascularization or any other condition. Intravitreal triamcinolone has been studied in animals for retinal neovascularization and proliferative vitreoretinopathy.…”

Pharmacokinetics of intravitreal 5‐fluorouracil prodrugs in silicone oil: experimental studies in pigs

“…From previously published data concerning the 5-FU clearance from vitrectomized rabbit vitreous, it can be calculated that with a sustained intravitreal concentration of 50 mg/ml, the entire amount of injected 5-FU would be exhausted in less than 18 days (Jarus et al 1985). However, concentrations above 50 mg/ml were maintained for more than 42 days, and concentrations above 10 mg/ml were maintained for more than 84 days with this codrug (Yang et al 1998).…”

Immunohistochemical characterization of sub retinalmembranes (SRMs) in proliferative vitreoretinopathy

“…19,23 Low dose intra vitreal triamcinolone, anti-proliferative and anti-neoplastic medications have shown some benefit in PVR if combined with surgery. 24…”

Safety of an Intravitreal Injection of Triamcinolone

“…These include embolic retinal artery occlusion and accidental penetration or perforation of the globe. [16][17][18][19] The findings from our study neither advocate nor support the use of intravitreal corticosteroids for the treatment of retinal neovascularization or any other condition. Intravitreal triamcinolone has been studied in animals for retinal neovascularization and proliferative vitreoretinopathy.…”

Pharmacokinetics of intravitreal 5‐fluorouracil prodrugs in silicone oil: experimental studies in pigs

“…From previously published data concerning the 5-FU clearance from vitrectomized rabbit vitreous, it can be calculated that with a sustained intravitreal concentration of 50 mg/ml, the entire amount of injected 5-FU would be exhausted in less than 18 days (Jarus et al 1985). However, concentrations above 50 mg/ml were maintained for more than 42 days, and concentrations above 10 mg/ml were maintained for more than 84 days with this codrug (Yang et al 1998).…”

Immunohistochemical characterization of sub retinalmembranes (SRMs) in proliferative vitreoretinopathy

“…19,23 Low dose intra vitreal triamcinolone, anti-proliferative and anti-neoplastic medications have shown some benefit in PVR if combined with surgery. 24…”