2016
DOI: 10.18632/aging.101029
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Abstract: Adaptation to an environmental or metabolic perturbation is a feature of the evolutionary process. Recent insights into microRNA function suggest that microRNAs serve as key players in a robust adaptive response against stress in animals through their capacity to fine-tune gene expression. However, it remains largely unclear how a microRNA-modulated downstream mechanism contributes to the process of homeostatic adaptation. Here we show that loss of an intestinally expressed microRNA gene, mir-60, in the nemato… Show more

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Cited by 22 publications
(14 citation statements)
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References 89 publications
(94 reference statements)
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“…elegans , WormExp 31 ; a high-quality protein-DNA interaction network 32 ; and two databases of miRNA-target interactions: the in silico predicted TargetScan 33 and the experimentally validated MirTarBase 34 . Enrichment analysis of the list detected ten hits already experimentally characterised as regulators of aging: DAF-16 35 , ELT-2 36 , ELT-6 37 , PMK-1 38,39 , PQM-1 40 , NHR-1, NHR-10, NHR-86 41 , let -7 42,43 , and miR-60 44 .…”
Section: Resultsmentioning
confidence: 99%
“…Human ISY1 facilitates the processing of primary transcripts encoding certain families of microRNAs ( Du et al, 2015 ). Both zip-10 and asp-17 are up-regulated in a mutant C. elegans strain deficient in the microRNA mir-60 ( Kato et al, 2016 ). We thus tested whether mir-60 mediates the regulation of zip-10 by ISY-1.…”
Section: Resultsmentioning
confidence: 99%
“…28 The loss of miR-60 contributes to adaptive response against chronic oxidative stress via ensuring the maintenance of cellular homeostasis. 29 In the result of pathway enrichment (Figure 4), several important pathways were obviously upregulated in C. elegans when exposed to SiNPs, for example, mTOR signaling pathway, Foxo signaling pathway, and longevity regulating pathway, while lysosome was a notably downregulated pathway. Studies showed that the TOR pathway influencing the aging of C. elegans may contribute to interacting with the insulin signaling pathway.…”
Section: Discussionmentioning
confidence: 99%
“…28 The loss of miR-60 contributes to adaptive response against chronic oxidative stress via ensuring the maintenance of cellular homeostasis. 29 …”
Section: Discussionmentioning
confidence: 99%
“…In a recent paper, it was reported that miR-60 is expressed almost exclusively in the intestine and directly modulates genes functioning in intestinal endocytosis. Furthermore, C.elegans animals lacking miR-60 have a dramatically extended lifespan under chronic oxidative stress condition [55]. Despite 3-fold upregulation of miR-253 during aging, no significant change in lifespan was observed for miR-253 mutants [56], suggesting a redundant, parallel route to modulation of the same targets.…”
Section: Mirnasmentioning
confidence: 97%