PLoS ONE volume 9, issue 5, Pe98419 2014 DOI: 10.1371/journal.pone.0098419 View full text
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Jie Xiong, Zhitong Bing, Yanlin Su, Defeng Deng, Xiaoning Peng

Abstract: Although patients with Glioblastoma multiforme (GBM) have grave prognosis, significant variability in patient outcome is observed. The objective of this study is to identify a molecular signature for GBM prognosis. We subjected 355 mRNA and microRNA expression profiles to elastic net-regulated Cox regression for identification of an integrated RNA signature for GBM prognosis. A prognostic index (PI) was generated for patient stratification. Survival comparison was conducted by Kaplan-Meier method and a general…

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