2010
DOI: 10.1111/j.1369-1600.2010.00276.x View full text |Buy / Rent full text
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Abstract: Alcohol drinking is highly prevalent in many cultures and contributes to the global burden of disease. In fact, it was shown that alcohol constitutes 3.2% of all worldwide deaths in the year 2006 and is linked to more than 60 diseases, including cancers, cardiovascular diseases, liver cirrhosis, neuropsychiatric disorders, injuries and foetal alcohol syndrome. Alcoholism, which has been proven to have a high genetic load, is one potentially fatal consequence of chronic heavy alcohol consumption, and may be reg… Show more

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“…We are also grateful to Thamil Annamalai, Wondwessen Mengesha for conducting the rat PK studies; Wendy Luo and Deborah Behrman for analytical PK sample analyses, Dr Juthamas Sukbuntherng and Shubhra Upadhyay for calculating PK parameters; Emily Tate and Heather Kerr for managing cell culture support; Sheila Irao, Dong Zhang, George Chiang, and Mirna Rodriguez for mGluR transfection and expression experiments, and clone selection; Tracy Dias and Tania Chernov-Rogan for the in vitro receptor binding studies and running the functional assays; Dr David J. Wustrow for general support and valuable stimulating discussions, Toño Estrada and Yanping Pu for technical assistance. This work was supported by the Bundesministerium für Bildung und Forschung (NGFN Plus; FKZ: 01GS08152, see under Spanagel et al, 2010(Spanagel et al, 2010 and www.ngfnalkohol.de). AJL is a Principal Fellow of the NHMRC, Australia and also supported by the Victorian Government's Operational Infrastructure Support Program.…”
Section: Acknowledgementsmentioning
“…Alcohol drinking is highly prevalent in many cultures and contributes to the global burden of disease. In fact, it was shown that alcohol constitutes 3.2% of all worldwide deaths in the year 2006 and is linked to more than 60 diseases, including cancers, cardiovascular diseases, liver cirrhosis, neuropsychiatric disorders, injuries and foetal alcohol syndrome (Spanagel et al 2010).…”
Section: Human Poisoning and Alcoholismmentioning
“…Taken together, genetic vulnerability to the effects of MDMA may explain at least some of the individual differences observed in the present study. Indeed, the notion of significant individual differences in response to MDMA being mediated via genetic polymorphisms is reminiscent of current findings in drug toxicity (Spanagel et al, 2010;Johansson and Ingelman-Sundberg, 2011). The role of genetics in mediating Fig.…”
Section: Discussionmentioning
“…A major theme in alcoholism research is the influence of genetics on risk, e.g., [1]. Accurate endophenotyping is critical for genetic studies.…”
Section: Introductionmentioning
“…Acknowledgements This work was supported by the Bundesministerium für Bildung und Forschung (NGFN Plus; FKZ: 01GS08152, FKZ: 01GS08155 see under www.ngfn-alkohol.de and Spanagel et al [44]; FKZ: 01GS08151 and funding from the Bernstein Center for Computational Neuroscience initiative; FKZ: 01GQ1003B).…”
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