An information rich biomedical polymer library

Pedone, Elisa; Li, Xiongwei; Koseva, Neli; Alpar, Oya; Brocchini, Steve

doi:10.1039/b306857a

Cited by 45 publications

(32 citation statements)

References 69 publications

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“…[11] Smith et al observed that the extent of grafting of an RGD peptide onto polyNAS decreased with increasing pH value and temperature owing to promotion of hydrolysis. [11] Cline and Hanna have noted that the reactivity of various amines towards aminolysis of p-nitrobenzoyl-Nhydroxysuccinimide in anhydrous dioxane correlated strongly with the basicity of the amino group, though steric hindrance within the investigated set of amines caused certain deviations [11,16] diNAS [8] NAS [18] NMAS [9,15,19] NAS [20] NSVB [20] NAS [4,13] NMAS [21,22] NSVB [23] NNHS [24] PFA [6] PFMA [6] PFVB [25] PFMA [26] NPF [7] NPA [27] NPMA [28] NPA [29] NPMA [30] MAPTT [10] 3 MA [17] MA [31] MA [32] MVI [17,33] VI [33] TMI [34] VDM [35,36] VDM [37] VDM [38] VPDMO [38] IDMO [38] GMA [39] GMA [40] 4-ES [41] GMA [42] GA [43] GMA …”

Section: Reviews 50mentioning

confidence: 98%

Synthesis of Functional Polymers by Post‐Polymerization Modification

2008

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Post-polymerization modification is based on the direct polymerization or copolymerization of monomers bearing chemoselective handles that are inert towards the polymerization conditions but can be quantitatively converted in a subsequent step into a broad range of other functional groups. The success of this method is based on the excellent conversions achievable under mild conditions, the excellent functional-group tolerance, and the orthogonality of the post-polymerization modification reactions. This Review surveys different classes of reactive polymer precursors bearing chemoselective handles and discusses issues related to the preparation of these reactive polymers by direct polymerization of appropriately functionalized monomers as well as the post-polymerization modification of these precursors into functional polymers.

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Section: Reviews 50mentioning

confidence: 98%

Synthesis of Functional Polymers by Post‐Polymerization Modification

2008

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“…Sequential conversion with different amines led to a polymer library containing different ratios of tertiary amines, quaternary ammonium, imidazole and hydroxypropyl moieties, which showed the ability to complex plasmid DNA. 31 Pan and coworkers use the same amphiphilic block copolymer PEO-b-PNHSA to form micelles in aqueous solution. Stable core crosslinked micelles could be obtained upon reaction of the PNHSA chains with ethylene diamine.…”

Section: Preparation Of Defined Reactive Polymer Architectures By Conmentioning

confidence: 99%

Synthesis of well‐defined polymeric activated esters

Théato

2008

J. Polym. Sci. A Polym. Chem.

276

260

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Monomers bearing an activated ester group can be polymerized under various controlled polymerization techniques, such as ATRP, NMP, RAFT polymerization, or ROMP. Combining the functionalization of polymers via polymeric activated esters with these controlled polymerization techniques generate possibilities to realize highly functionalized polymer architectures. Within this highlight two different research areas of activated esters in polymer science will be discussed: (i) the preparation of defined reactive polymer architectures by controlled polymerization techniques and (ii) the preparation of defined reactive thin films. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 6677–6687, 2008

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“…In another study, chemists synthesized a combinatorial polycation library based on tertiary amine, quaternary ammonium, immidazole, and hydroxypropyl conjugated methacrylates block copolymerized with PEG [45]. The aim of this study was to use a minimal number of polymers to obtain relevant information about structure-property correlations.…”

Section: Combinatorial Studies Of Polymethacrylates In Biological mentioning

confidence: 99%

Exploration of polymethacrylate structure–property correlations: Advances towards combinatorial and high-throughput methods for biomaterials discovery

Holmes

Bohrer

Kohn

2008

Progress in Polymer Science

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In this review, we discuss the synthesis, characterization, physical properties, and applications of polymethacrylates and describe physical and biological structure-property correlations relevant to many high performance applications. We also track the advancement of material-property space from the 'traditional' mode of materials design to the emerging, state-of-the-art combinatorial and in silico methods. Particularly, this article places emphasis on recent advances in the automated combinatorial synthesis and development of high-throughput characterization methods. As a future perspective, we believe that the realization of combinatorial, high-throughput, and computational methods will allow for the rapid exploration of a vast polymethacrylate library property space.

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An information rich biomedical polymer library

Cited by 45 publications

References 69 publications

Synthesis of Functional Polymers by Post‐Polymerization Modification

Synthesis of Functional Polymers by Post‐Polymerization Modification

Synthesis of well‐defined polymeric activated esters

Exploration of polymethacrylate structure–property correlations: Advances towards combinatorial and high-throughput methods for biomaterials discovery

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