An increased throughput method for determination of phase diagrams—method development and validation

Imberg, Anna

doi:10.1016/s0927-7757(03)00101-8

Cited by 8 publications

(10 citation statements)

References 6 publications

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“…When there were only trace amounts of solvent left, PG and water were added by the robot, and the vials were sealed and left standing at room temperature (20 ± 1 °C) to reach equilibrium. The robot method for sample preparation has been described elsewhere …”

Section: Methodsmentioning

confidence: 99%

Cubic, Sponge, and Lamellar Phases in the Glyceryl Monooleyl Ether−Propylene Glycol−Water System

2007

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The phase behavior of 1-glyceryl monooleyl ether (GME) in mixtures of propylene glycol (PG) and water was investigated by visual inspection, polarization microscopy, small-angle X-ray diffraction, and conductance measurements. A phase diagram, based on over 200 samples of the ternary system GME-PG-water, was constructed at 20 degrees C. Without PG, GME forms a reverse micellar phase with up to 10 wt % water and a reverse hexagonal liquid-crystalline phase between 10 and 25 wt % water, a phase that can coexist with excess water. If PG is added in amounts exceeding about 10 wt %, then cubic and lamellar liquid-crystalline phases start to form. A cubic phase, belonging to space group Pn3m, can coexist with excess PG-water mixtures. If even more PG is added, then the cubic phase is transformed into a sponge phase. A lamellar phase forms at water contents between 10 and 15 wt % and with widely differing PG/GME weight ratios. We postulate that the phase behavior is caused by the fact that PG makes the interfacial region between self-assembled GME and PG-water less negatively curved, which in turn allows for the formation of the new phases. The phase behavior obtained for the GME system shows a striking similarity with the phase behavior of the corresponding system in which the GME has been replaced by the ester, 1-glycerol monooleate (GMO), differing only in one extra carbonyl oxygen. The major difference is the lower amount of water present in the GME phases, an effect that is mainly due to the more hydrophobic character of GME compared to that of GMO.

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Section: Methodsmentioning

confidence: 99%

Cubic, Sponge, and Lamellar Phases in the Glyceryl Monooleyl Ether−Propylene Glycol−Water System

2007

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“…After evaporation propylene glycol (PG) and water were added to each vial in appropriate amounts and the vials were finally sealed. The robot method for sample preparation has been described elsewhere [27]. Hereafter, all concentrations are given as weight percent (%, w/w) calculated on the total sample weight unless stated otherwise.…”

Section: Sample Preparationmentioning

confidence: 99%

Aqueous self-assembly of phytantriol in ternary systems: Effect of monoolein, distearoylphosphatidylglycerol and three water-miscible solvents

Wadsten-Hindrichsen

Bender

Unga

et al. 2007

Journal of Colloid and Interface Science

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“…The samples for the phase diagrams containing polymer were all prepared manually (0.5 g/sample). The samples for the EtAc/MO/water phase diagram were prepared by a robotic liquid handler in accordance with a recently reported method . To enhance mixing and equilibration, all samples were vortexed and centrifuged.…”

Section: Methodsmentioning

confidence: 99%

“…The samples for the EtAc/ MO/water phase diagram were prepared by a robotic liquid handler in accordance with a recently reported method. 13 To enhance mixing and equilibration, all samples were vortexed and centrifuged. The anisotropy of the samples was studied between crossed polarizers.…”

Section: Introductionmentioning

confidence: 99%

Segregation of Lipid and Polymer in Emulsion Droplets Captured by Confocal Laser Scanning Microscopy

Imberg

Hansson

2005

J. Phys. Chem. B

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The phase behaviors of the subsystems of the ethyl acetate (EtAc)/monoolein/polyethylene glycol-poly(D,L-lactide-co-glycolide) (PLG)/water system have been determined. EtAc simultaneously solves MO and PLG in a liquid phase, denoted L. Lipid/polymer composite particles have here been formed by emulsification of such an L phase into aqueous solutions. Characterization, by means of confocal laser scanning microscopy, revealed that distinctive lipid domains appear inside the particles. In aqueous solutions, these lipid domains swell and finally leave the concentrated polymer matrix. The system exhibits a suitable phase behavior in order to form lipid/polymer composite particles. These composite particles may be interesting for drug delivery applications.

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An increased throughput method for determination of phase diagrams—method development and validation

Cited by 8 publications

References 6 publications

Cubic, Sponge, and Lamellar Phases in the Glyceryl Monooleyl Ether−Propylene Glycol−Water System

Cubic, Sponge, and Lamellar Phases in the Glyceryl Monooleyl Ether−Propylene Glycol−Water System

Aqueous self-assembly of phytantriol in ternary systems: Effect of monoolein, distearoylphosphatidylglycerol and three water-miscible solvents

Segregation of Lipid and Polymer in Emulsion Droplets Captured by Confocal Laser Scanning Microscopy

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