Avijit Ray, Sreemanti Basu, Nichole M. Miller, Andrew M. Chan, Bonnie N. Dittel
R-Ras is a member of the Ras superfamily of small GTPases, which are regulators of various cellular processes including adhesion, survival, proliferation, trafficking and cytokine production. R-Ras is expressed by immune cells and has been shown to modulate DC function in vitro and has been associated with liver autoimmunity. We used Rras-deficient mice to study the mechanism whereby R-Ras contributes to autoimmunity using experimental autoimmune encephalomyelitis (EAE), a mouse model of the CNS autoimmune di…
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