volume 192, issue 11, P5109-5117 2014
DOI: 10.4049/jimmunol.1302254
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Avijit Ray, Sreemanti Basu, Nichole M. Miller, Andrew M. Chan, Bonnie N. Dittel

Abstract: R-Ras is a member of the Ras superfamily of small GTPases, which are regulators of various cellular processes including adhesion, survival, proliferation, trafficking and cytokine production. R-Ras is expressed by immune cells and has been shown to modulate DC function in vitro and has been associated with liver autoimmunity. We used Rras-deficient mice to study the mechanism whereby R-Ras contributes to autoimmunity using experimental autoimmune encephalomyelitis (EAE), a mouse model of the CNS autoimmune di…

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