An In vitro test for teratogens: Its practical application

Effects of Dibutyl Phthalate and Monobutyl Phthalate on Cytotoxicity and Differentiation in Cultured Rat Embryonic Limb Bud Cells; Protection by Antioxidants

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Effects of Dibutyl Phthalate and Monobutyl Phthalate on Cytotoxicity and Differentiation in Cultured Rat Embryonic Limb Bud Cells; Protection by Antioxidants

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Evaluation of Embryotoxic Potential of Olaquindox and Vitamin A in Micromass Culture and in Rats

“…In this experiment for olaquindox, IC 50 values of proliferation and differentiation for CNS cell were 22.74 and 28.32 μg/ml, and 79.34 and 23.29 μg/ml for LB cell, respectively. Compounds with IC 50 below 50~75 μg/ml on differentiation could be considered as potential of teratogenicity and 7~10 μg/ml or less with a high solubility may indicate high teratogenic risk (Flint, 1986) . In vivo , development toxicant produce adverse effects on the fetus at exposure levels that do not induce severe toxicity in the mother such as substantial reduction in weight gain.…”

Lack of Teratogenicity of 3‐Chloro‐4‐(Dichloromethyl)‐5‐Hydroxy‐2 (5H)‐Furanone (MX) in Embryonic Mouse Palate Culture in vitro

“…The estimated ICSO was as low as approximately 3 pg/ml for both midbrain and limb bud cell cultures. When these results are applied to the criteria of the micromass tests (Flint, 1986). MX can be classified as a compound with high teratogenic risk.…”

Effects of Dibutyl Phthalate and Monobutyl Phthalate on Cytotoxicity and Differentiation in Cultured Rat Embryonic Limb Bud Cells; Protection by Antioxidants

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Evaluation of Embryotoxic Potential of Olaquindox and Vitamin A in Micromass Culture and in Rats

“…In this experiment for olaquindox, IC 50 values of proliferation and differentiation for CNS cell were 22.74 and 28.32 μg/ml, and 79.34 and 23.29 μg/ml for LB cell, respectively. Compounds with IC 50 below 50~75 μg/ml on differentiation could be considered as potential of teratogenicity and 7~10 μg/ml or less with a high solubility may indicate high teratogenic risk (Flint, 1986) . In vivo , development toxicant produce adverse effects on the fetus at exposure levels that do not induce severe toxicity in the mother such as substantial reduction in weight gain.…”

Lack of Teratogenicity of 3‐Chloro‐4‐(Dichloromethyl)‐5‐Hydroxy‐2 (5H)‐Furanone (MX) in Embryonic Mouse Palate Culture in vitro

“…The estimated ICSO was as low as approximately 3 pg/ml for both midbrain and limb bud cell cultures. When these results are applied to the criteria of the micromass tests (Flint, 1986). MX can be classified as a compound with high teratogenic risk.…”

Effects of Dibutyl Phthalate and Monobutyl Phthalate on Cytotoxicity and Differentiation in Cultured Rat Embryonic Limb Bud Cells; Protection by Antioxidants

“……”

“……”

Evaluation of Embryotoxic Potential of Olaquindox and Vitamin A in Micromass Culture and in Rats

“…In this experiment for olaquindox, IC 50 values of proliferation and differentiation for CNS cell were 22.74 and 28.32 μg/ml, and 79.34 and 23.29 μg/ml for LB cell, respectively. Compounds with IC 50 below 50~75 μg/ml on differentiation could be considered as potential of teratogenicity and 7~10 μg/ml or less with a high solubility may indicate high teratogenic risk (Flint, 1986) . In vivo , development toxicant produce adverse effects on the fetus at exposure levels that do not induce severe toxicity in the mother such as substantial reduction in weight gain.…”

Lack of Teratogenicity of 3‐Chloro‐4‐(Dichloromethyl)‐5‐Hydroxy‐2 (5H)‐Furanone (MX) in Embryonic Mouse Palate Culture in vitro

“…The estimated ICSO was as low as approximately 3 pg/ml for both midbrain and limb bud cell cultures. When these results are applied to the criteria of the micromass tests (Flint, 1986). MX can be classified as a compound with high teratogenic risk.…”