An improved method to correct the QT interval of the electrocardiogram for changes in heart rate

Water, A. Van De; Verheyen, Jef; Xhonneux, R.; Reneman, R. S.

doi:10.1016/0160-5402(89)90015-6

Cited by 288 publications

(162 citation statements)

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“…However, the HR of dogs is much higher than that found in humans and, hence, the correct QT values provided by such equations diverge greatly from the original QT intervals . In contrast, the simple linear equation proposed by Van de Water et al (1989) yielded more consistent results for high HR. Thus, QTcV had the lowest coefficient of variation and the less variability, compared with the others.…”

Section: Discussionmentioning

confidence: 54%

“…Results from the present study indicate that the method proposed by Van de Water et al (1989) for correcting QT intervals is the most appropriate for application to dogs in small clinical practice because of its simplicity and reliability. The routine application of such approach would certainly assist the correct evaluation of the QT interval in order to precisely infer about abnormalities of the ventricular repolarization which predispose to occurrence of arrhythmias that must be diagnosis as early as better.…”

Section: Resultsmentioning

confidence: 91%

“…The routine application of such approach would certainly assist the correct evaluation of the QT interval in order to precisely infer about abnormalities of the ventricular repolarization which predispose to occurrence of arrhythmias that must be diagnosis as early as better. Bazett (1920), QTcF = QT interval corrected as Fridericia (1920), and QTcV = QT interval corrected according to Van de Water et al (1989). Different letters indicate statistical differences (ANOVA -Tukey ρ<0.05).…”

Section: Resultsmentioning

confidence: 99%

“…For calculation of the heart rate it was considered the duration of RR interval. QTc values were obtained from the following equations: QTcB = QT*(RR) 1/2 (Bazett 1920); QTcF = QT*(RR) 1/3 (Fridericia 1920) and QTcV = QT + 0.087(1-RR) ( Van de Water et al 1989).…”

Section: Methodsmentioning

confidence: 99%

“…The aim of the present study was to determine the suitable QT interval correction method obtained from healthy dogs, considering different breeds for the assessment of different HR ranges. In order to achieve this goal it was performed the formulae proposed by Bazett 1920, Fridericia 1920, and Van de Water et al 1989.…”

Section: Introductionmentioning

confidence: 99%

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QT interval in healthy dogs: which method of correcting the QT interval in dogs is appropriate for use in small animal clinics?

Oliveira

Muzzi

et al. 2014

Pesq. Vet. Bras.

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Pesq. Vet. Bras. 34(5):469-472, maio 2014 469 RESUMO.-[Intervalo QT em cães hígidos: qual método de correção para o intervalo QT é mais apropriado na clínica de pequenos animais?] O intervalo QT do eletrocardiograma (ECG) é influenciado por variações da frequência cardíaca (FC), o que pode levar a erros na interpretação de sua duração. Considerando que as alterações na duração do intervalo QT refletem anormalidades da repolarização ventricular, as quais predispõem a ocorrência de arritmias, esta variável deve ser devidamente avaliada. O objetivo deste trabalho foi determinar qual método de correção do intervalo QT é mais adequado para os cães, considerando-se diferentes intervalos de FC normais. Cães adultos saudáveis, de diferentes raças (n=130; Pastor Alemão, Boxer, Pit Bull Terrier e Poodle) foram submetidos ao exame eletrocardiográfico, no qual se determinaram os intervalos QT a partir da derivação bipolar II e foram corrigidos os efeitos da FC por meio da aplicação de três fórmulas, envolvendo regressão quadrática, cúbica ou linear. Os valores do QT corrigido (QTc) obtidos utilizando as diversas fór-mulas foram significativamente diferentes (ρ<0,05), sendo os derivados da equação QTcV = QT + 0,087 (1-RR), os mais consistentes (regressão linear). The electrocardiography (ECG) QT interval is influenced by fluctuations in heart rate (HR) what may lead to misinterpretation of its length. Considering that alterations in QT interval length reflect abnormalities of the ventricular repolarisation which predispose to occurrence of arrhythmias, this variable must be properly evaluated. The aim of this work is to determine which method of correcting the QT interval is the most appropriate for dogs regarding different ranges of normal HR (different breeds). Healthy adult dogs (n=130; German Shepherd, Boxer, Pit Bull Terrier, and Poodle) were submitted to ECG examination and QT intervals were determined in triplicates from the bipolar limb II lead and corrected for the effects of HR through the application of three published formulae involving quadratic, cubic or linear regression. The mean corrected QT values (QTc) obtained using the diverse formulae were significantly different (ρ<0.05), while those derived according to the equation QTcV = QT + 0.087(1-RR) were the most consistent (linear regression). QTcV values were strongly correlated (r=0.83) with the QT interval and showed a coefficient of variation of 8.37% and a 95% confidence interval of 0.22-0.23 s. Owing to its simplicity and reliability, the QTcV was considered the most appropriate to be used for the correction of QT interval in dogs. intervalo de confiança de 95% de 0,22-0,23s. Devido à confiabilidade dos dados, o QTcV foi considerado o mais apropriado para ser utilizado para a correção do intervalo QT em cães, além de ser um método de fácil execução.

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Section: Discussionmentioning

confidence: 54%

Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

QT interval in healthy dogs: which method of correcting the QT interval in dogs is appropriate for use in small animal clinics?

Oliveira

Muzzi

et al. 2014

Pesq. Vet. Bras.

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An Overview of QT Interval Assessment in Safety Pharmacology

2013

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Medicinal products that prolong cardiac repolarization, as assessed in terms of prolongation of the QT interval of the electrocardiogram, may trigger torsade de pointe, a potentially fatal arrhythmia. The lethality of this risk necessitates a detailed preclinical evaluation before initiating clinical trials. The strategy for assessing the potential of new chemical entities to cause QT interval prolongation involves two complementary approaches. An in vivo test provides information on the potential of the agent to prolong the QT interval under near-physiological conditions. The results are mostly descriptive, providing little insight into the mechanisms of action. In vitro experiments provide more mechanistic data, although the test procedure is far removed from the clinical situation. While both approaches have reasonable predictive value, the results may depend largely on the experimental conditions employed. Discussed in this unit are experimental issues that should be considered when testing agents for their potential to cause arrhythmias, as well as general strategies for understanding the problems associated with this cardiovascular risk.

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Cardiovascular Liabilities of Drugs: Regulatory Aspects

Arrigoni¹

2010

Cardiotoxicity of Non‐Cardiovascular Drugs

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An improved method to correct the QT interval of the electrocardiogram for changes in heart rate

Cited by 288 publications

References 8 publications

QT interval in healthy dogs: which method of correcting the QT interval in dogs is appropriate for use in small animal clinics?

QT interval in healthy dogs: which method of correcting the QT interval in dogs is appropriate for use in small animal clinics?

An Overview of QT Interval Assessment in Safety Pharmacology

Cardiovascular Liabilities of Drugs: Regulatory Aspects

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