An fMRI Study on the Time-Limited Role of the Medial Temporal Lobe in Long-Term Topographical Autobiographic Memory

Niki, Kiyomi; Luo, Junlong

doi:10.1162/089892902317362010

Cited by 90 publications

(91 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SCM predicts greater hippocampal activity for recent than remote AMs (i.e., a remoteness effect), whereas MTT predicts that if both types of AMs are equally detailed and vivid, they should elicit similar hippocampal activity (i.e., no remoteness effect). Although a few functional neuroimaging studies found the remoteness effect predicted by SCM (Niki & Luo, 2002;Piefke, et al, 2003) most of the studies comparing remote and recent AMs did not, supporting MTT Conway, et al, 1999;Gilboa, et al, 2004;Maguire & Frith, 2003b;Maguire, et al, 2001;Piolino et al, 2004;Rekkas & Constable, 2005;Ryan, et al, 2001;Viard et al, 2007) and consistent with emerging evidence in the patient literature, which suggests that MTL damage can impact remote AMs greater than was previously found (Steinvorth, et al, 2005). However, neuroimaging evidence cannot irrefutably determine the necessity of the hippocampus in the retrieval of remote AMs.…”

Section: Remote Autobiographical Memoriessupporting

confidence: 55%

See 1 more Smart Citation

Functional neuroimaging of autobiographical memory

Cabeza

Jacques

2007

Trends in Cognitive Sciences

640

552

View full text Add to dashboard Cite

Autobiographical memory (AM) refers to memory for events from our own personal past. Functional neuroimaging studies of AM are important because they can investigate the neural correlates of processes that are difficult to study using laboratory stimuli, including: complex constructive processes, subjective qualities of memory retrieval, and remote memory. Three functional magnetic resonance imaging (fMRI) studies are presented to examine these important contributions of AM. The first study investigates the neural correlates of temporal-order memory for autobiographical events using a novel photo paradigm. Participants took photographs at many campus locations over a period of several hours, and the following day they were scanned while making temporal-order judgments to pairs of photographs from different locations. It was found that temporal-order decisions associated with recollection recruited left prefrontal (PFC) and left posterior parahippocampal cortex, whereas temporal-order decisions relying on familiarity recruited greater activity in the right PFC.The second study examines self-projection, the capacity to re-experience the personal past and to mentally infer another person's perspective. A novel camera technology was used to examine self-projection by prospectively generating dynamic visuospatial images taken from a first-person perspective. Participants were literally asked to self-project into the personal past or into the life of another person. Selfv projection of one's own past self recruited greater ventral medial PFC (mPFC), and selfprojection of another individual recruited dorsal mPFC. Activity in ventral vs. dorsal mPFC was also sensitive to the ability to relive or understand the perspective taken on each trial. Further, task-related functional connectivity analysis revealed that ventral mPFC contributed to the medial temporal lobe network linked to memory processes, whereas dorsal mPFC contributed to the frontoparietal network linked to controlled processes.The third study focuses on the neural correlates underlying age-related differences in the recall of episodically rich AMs. Age-related attenuation in the episodic richness of AM was linked to reductions in activity elicited during elaboration.Age effects on AM were more pronounced during elaboration than search, with older adults showing less sustained recruitment of the hippocampus and ventrolateral PFC for less episodically rich AMs. Further, there was an age-related reduction in the top-down modulation of the PFC on the hippocampus by episodic richness, possibly reflecting fewer controlled processes operating on the recovery of information in the hippocampus.Ultimately, the goal of all memory research is to understand how memory operates in the real-world; the present research highlights the important contribution of functional neuroimaging studies of AM in attaining this goal.vi

show abstract

Section: Remote Autobiographical Memoriessupporting

confidence: 55%

“…Moreover, there is evidence that different PFC regions are activated depending on the age of the AMs (Niki & Luo, 2002;Rekkas & Constable, 2005).…”

Section: Age Of the Participants Investigating The Neural Correlatesmentioning

confidence: 99%

Functional neuroimaging of autobiographical memory

Cabeza

Jacques

2007

Trends in Cognitive Sciences

640

552

View full text Add to dashboard Cite

show abstract

“…The remaining six papers discussed by Maguire (2001), plus two other recent papers (Markowitsch et al, 2000;Niki & Luo, 2002), have addressed two main issues with respect to the neural basis of autobiographicalmemory: (1) whether some regions of the brain, especially the hippocampus and other medial temporal lobe regions, are more involved in the retrieval of recent memories (Conway et al, 1999;Maguire, Henson, Mummery, & Frith, 2001;Niki & Luo, 2002;Ryan et al, 2001), and (2) the role played by more lateral temporal and frontal regions in the retrieval of personal events (Conway et al, 1999;Fink et al, 1996;Maguire & Mummery, 1999;Maguire et al, 2000;Markowitsch et al, 2000). Until Niki and Luo, there was relatively little evidence that hippocampal regions were more active during the retrieval of recent in comparison with remote memories (see Murre, Graham, & Hodges, 2001;Nadel, Samsonovich, Ryan, & Moscovitch, 2000;Nestor, Graham, Bozeat, Simons, & Hodges, 2002;Squire, 1992, for theoretical reviews about this issue).…”

Section: Functional Neuroimaging Studies Of Autobiographical Memorymentioning

confidence: 99%

The neural basis of autobiographical and semantic memory: New evidence from three PET studies

Graham

Lee

Brett

et al. 2003

Cognitive, Affective, & Behavioral Neuroscience

121

View full text Add to dashboard Cite

“…On the one hand, several recent functional activation studies in healthy volunteers have provided evidence that the hippocampus and related medial temporal lobe structures are more activated during the retrieval of recent compared with remote episodic memories (Haist et al 2001;Niki and Luo 2002;Piefke et al 2003;Mayes et al 2004). These investigations have used autobiographical or famous faces tasks, and the findings could be interpreted as consistent with consolidation theory.…”

mentioning

confidence: 99%

Retrograde amnesia in patients with hippocampal, medial temporal, temporal lobe, or frontal pathology

Bright¹,

Buckman²,

Fradera³

et al. 2006

Learn. Mem.

View full text Add to dashboard Cite

There is considerable controversy concerning the theoretical basis of retrograde amnesia (R.A.). In the present paper, we compare medial temporal, medial plus lateral temporal, and frontal lesion patients on a new autobiographical memory task and measures of the more semantic aspects of memory (famous faces and news events). Only those patients with damage extending beyond the medial temporal cortex into the lateral temporal regions showed severe impairment on free recall remote memory tasks, and this held for both the autobiographical and the more semantic memory tests. However, on t-test analysis, the medial temporal group was impaired in retrieving recent autobiographical memories. Within the medial temporal group, those patients who had combined hippocampal and parahippocampal atrophy (H + ) on quantified MRI performed somewhat worse on the semantic tasks than those with atrophy confined to the hippocampi (H − ), but scores were very similar on autobiographical episodic recall. Correlational analyses with regional MRI volumes showed that lateral temporal volume was correlated significantly with performance on all three retrograde amnesia tests. The findings are discussed in terms of consolidation, reconsolidation, and multiple trace theory: We suggest that a widely distributed network of regions underlies the retrieval of past memories, and that the extent of lateral temporal damage appears to be critical to the emergence of a severe remote memory impairment.The neural bases of retrograde amnesia and long-term memory functions remain key issues in cognitive neuroscience. In particular, the time course of medial temporal lobe (MTL) involvement in the storage and retrieval of remote memories has not been resolved. The present study examines performance across a range of measures of remote memory in amnesic patients with focal medial temporal lobe pathology, more widespread temporal lobe damage, and frontal lobe damage. The purpose is to test theoretical predictions concerning the nature of retrograde amnesia.Despite a proliferation of studies on memory and its disorders over the last three to four decades, many of the critical issues are still widely debated (Kopelman 2002(Kopelman , 2006. There are two main theoretical positions currently discussed in the literature regarding the role of MTL structures in the retrieval of remote memories, each of which makes distinct predictions about how remote memory is affected by the physical location and extent of brain damage. According to the consolidation model (ZolaMorgan and Squire 1990; Squire 1992; Squire and Alvarez 1995), episodic (autobiographical events) and semantic memories are processed in the same way, initially dependent on the hippocampal formation, but over time they become represented in the neocortex, independently of medial temporal structures. In contrast, multiple trace theory Moscovitch 1997, 2001;Nadel et al. 2000;Moscovitch et al. 2006) proposes a critical distinction between semantic and episodic memory. Retrieval of episodic (and spatial) memo...

show abstract

An fMRI Study on the Time-Limited Role of the Medial Temporal Lobe in Long-Term Topographical Autobiographic Memory

Cited by 90 publications

References 20 publications

Functional neuroimaging of autobiographical memory

Functional neuroimaging of autobiographical memory

The neural basis of autobiographical and semantic memory: New evidence from three PET studies

Retrograde amnesia in patients with hippocampal, medial temporal, temporal lobe, or frontal pathology

Contact Info

Product

Resources

About