An fMRI motor activation paradigm demonstrates abnormalities of putamen activation in females with panic disorder

Marchand, William R.; Lee, James N.; Healy, Lindsey; Thatcher, John W.; Rashkin, Esther; Starr, Jennifer; Hsu, Ed

doi:10.1016/j.jad.2008.10.026

Cited by 36 publications

(17 citation statements)

References 19 publications

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“…Further, since subjects were not performing motor tasks, these investigators hypothesized that the observed basal ganglia activation may facilitate a state of motor readiness to respond to danger. Other investigators have reported basal ganglia activation in response to threat (Phelps et al 2001) and abnormal activation in panic disorder (Marchand et al 2009), further supporting a role of the cortico-basal ganglia circuitry in the motor fear response.…”

Section: Emotional Processing Mechanismsmentioning

confidence: 80%

“…Studies have reported striatal functional abnormalities in panic disorder (Marchand et al 2009), social phobia (Lorberbaum et al 2004;Sareen et al 2007), OCD (Maltby et al 2005;Nakao et al 2005;Woolley et al 2008) and in response to treatment for OCD (Lazaro et al 2008;Freyer et al 2010). Further, a study of panic disorder found that functional connectivity between the amygdala and prefrontal cortical areas and thalamus during the processing of angry facial expressions was significantly stronger in women than in men (Ohrmann et al 2010).…”

Section: Studies Of Mood and Anxiety Disordersmentioning

confidence: 99%

“…While not all results have been consistent, there is considerable evidence of aberrant functioning of these circuits in a diverse group of mood and anxiety disorders. Examples including bipolar disorder (Malhi et al 2004a, b;Caligiuri et al 2006;Marchand et al 2007b, c), unipolar depression (Baxter et al 1985;Naismith et al 2006;Polgar et al 2007;Kumar et al 2008), panic disorder (Marchand et al 2009), OCD (Harrison et al 2009;Olver et al 2009;Rotge et al 2009) and social phobia (Sareen et al 2007;van der Wee et al 2008). Therefore, understanding potential mechanisms by which cortico-basal ganglia circuit dysfunction might play a role in the neurobiology of mood and anxiety disorders is necessary to fully characterize the pathology of these conditions.…”

Section: Introductionmentioning

confidence: 99%

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Cortico-basal ganglia circuitry: a review of key research and implications for functional connectivity studies of mood and anxiety disorders

Marchand

2010

Brain Struct Funct

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There is considerable evidence that dysfunction of the cortico-basal ganglia circuits may be associated with several mood and anxiety disorders. However, it is unclear whether circuit abnormalities contribute directly either to the neurobiology of these conditions or to the manifestation of symptoms. Understanding the role of these pathways in psychiatric illness has been limited by an incomplete characterization of normal function. In recent years, studies using animal models and human functional imaging have greatly expanded the literature describing normal cortico-basal ganglia circuit function. In this paper, recent key studies of circuit function using human and animal models are reviewed and integrated with findings from other studies conducted over the previous decades. The literature suggests several hypotheses of cortico-basal ganglia circuitry function in mood and anxiety disorders that warrant further exploration. Hypotheses are proposed herein based upon the cortico-basal ganglia mechanisms of: (1) feedforward and feedback control, (2) circuit integration and (3) emotional control. These are presented as models of circuit function, which may be particularly relevant to future investigations using neuroimaging and functional connectivity analyses.

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Section: Emotional Processing Mechanismsmentioning

confidence: 80%

Section: Studies Of Mood and Anxiety Disordersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cortico-basal ganglia circuitry: a review of key research and implications for functional connectivity studies of mood and anxiety disorders

Marchand

2010

Brain Struct Funct

Self Cite

120

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“…These include controlling motor learning, motor performance and tasks (DeLong et al, 1984a), motor preparation (Alexander & Crutcher, 1990), specifying amplitudes of movement (Delong et al, 1984b) and movement sequences (Marchand et al, 2009;Marchand et al, 2008). It has also been hypothesized to play a role in the selection of movement and the automatic performance of previously learned movement (Marchand et al, 2009). The insula is believed to be involved in consciousness and play a role in diverse functions usually linked to emotion or the regulation of the body's homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Assessing Human Cortical Activation and Network During Pitch Discrimination Task in Quiet and in Noisy Background

Yusoff¹,

Hamid²,

Mohamad³

et al. 2013

MAS

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In spite of extensive research conducted in studying pitch memory processing, knowledge about the functional anatomy of the brain while performing pitch discrimination task is still lacking. The purpose of this study was to investigate the effects of background noise and tonal frequencies on brain activation during a pitch discrimination task. Thirteen participants were presented with categories of low-and high-frequency tones during an fMRI scan. They listen, recognize and discriminate the target tone with the last tone in a series of four distracting tones. Cortical responses during which the participants engaged with the pitch discrimination task were explored globally and differentially with tonal frequency and background condition as factors. Similar integrative network consisting of bilateral superior temporal gyrus, pre-central gyrus, cerebellum, insula, putamen, inferior parietal lobe and supplementary motor area is established during the four pitch discrimination task conditions. The bilateral A1 and right M1 are effectively activated by noise and action respectively. Background noise increases the participants' performance hence equalizing that in quiet, while participants performed significantly better in discriminating low-frequency tones as compared to high-frequency tones. This study revealed an integrative network that consists of areas responsible for pitch discrimination strategy. The bilateral primary auditory cortex played important roles in increasing participants' pitch discrimination performance in noisy surrounding and in discriminating low frequency category of tones.

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“…We have reported that motor paradigms are effective probes of cortico-basal ganglia function in some mood and anxiety disorders (Marchand et al, 2009(Marchand et al, , 2007a(Marchand et al, , 2007b and therefore anticipate using this task in future studies of neuropsychiatric conditions. To that end, we wanted to define how age might impact activation and functional connectivity associated with this paradigm.…”

Section: Introductionmentioning

confidence: 99%

Age-related changes of the functional architecture of the cortico-basal ganglia circuitry during motor task execution

et al. 2011

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An fMRI motor activation paradigm demonstrates abnormalities of putamen activation in females with panic disorder

Cited by 36 publications

References 19 publications

Cortico-basal ganglia circuitry: a review of key research and implications for functional connectivity studies of mood and anxiety disorders

Cortico-basal ganglia circuitry: a review of key research and implications for functional connectivity studies of mood and anxiety disorders

Assessing Human Cortical Activation and Network During Pitch Discrimination Task in Quiet and in Noisy Background

Age-related changes of the functional architecture of the cortico-basal ganglia circuitry during motor task execution

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