An experimental study on the effects of ethanol and folic acid deficiency, alone or in combination, on pregnant Swiss mice

Gutierrez, Cristiane Minot; Ribeiro, Camila Nunes de Morais; Lima, Gerusa Marcondes Pimentel de Abreu; Yanaguita, Maira Yuli; Peres, Luíz César

doi:10.1080/00313020701449290

Cited by 13 publications

(13 citation statements)

References 32 publications

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“…Compared with control pregnancies, there was a 64% excess of miscarriage or postpartum litter death for low folate fed dams, suggesting that folate supply decreased capacity to carry pregnancy to term or rear pups effectively. Previous studies have reported lower www.mnf-journal.com reproductive success, measured as reduced litter size or increased number of fetal reabsorptions, in animals fed lowfolate diets [21,24,26,27] but, to our knowledge, no previous study investigating the influence of maternal folic acid intake has commented on the capacity to carry pregnancies to term or on rearing of pups to weaning. Furthermore, pups born to folate-depleted mothers were 6% lighter at weaning (p = 0.011) compared with those born to controls (confirming our previous observation [25]), which may reflect a lower birth weight and/or indicate reduced postpartum growth.…”

Section: Discussionmentioning

confidence: 86%

Metabolic effects of a high‐fat diet post‐weaning after low maternal dietary folate during pregnancy and lactation

McKay

Xie

Manus

et al. 2014

Molecular Nutrition Food Res

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Scope:Investigate the influence of low-folate supply during pregnancy and lactation on obesity and markers of the metabolic syndrome in offspring, and how provision of a high-fat diet post weaning may exacerbate the resultant phenotype. Methods and results: Female C57Bl/6 mice were randomized to low or normal folate diets (0.4 or 2 mg folic acid/kg diet) prior to and during pregnancy and lactation. At 4 wk of age, offspring were randomized to high-or low-fat diets, weighed weekly and food intake assessed at 9 and 18 wk old. Adiposity was measured at 3 and 6 months. Plasma glucose and triacylglycerol (TAG) concentrations were measured at 6 months. Maternal folate supply did not influence adult offspring body weight or adiposity. High-fat feeding post weaning increased body weight and adiposity at 3 and 6 months (p > 0.001). Maternal low folate lowered plasma glucose (p = 0.010) but increased plasma TAG (p = 0.048). High-fat feeding post weaning increased plasma glucose and TAG (p = 0.023, p = 0.049 respectively). Offspring from folate-depleted (but not folate-adequate) dams had 30% higher TAG concentration when fed the high-fat diet from weaning (p = 0.005 for interaction). Conclusion: Inadequate maternal folate intake has long-term effects on offspring metabolism, manifested as increased circulating TAG, particularly in offspring with high-fat intake post weaning.

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Section: Discussionmentioning

confidence: 86%

Metabolic effects of a high‐fat diet post‐weaning after low maternal dietary folate during pregnancy and lactation

McKay

Xie

Manus

et al. 2014

Molecular Nutrition Food Res

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“…After alcohol exposure during pregnancy in mice and rats, more adverse fetal effects were observed in those born to mothers receiving a folate free diet [30], [34]. Furthermore, several recent animal studies have reported that high dose folic acid can mitigate the adverse fetal effects induced by alcohol, especially measures of oxidative stress [25], [35]–[38].…”

Section: Resultsmentioning

confidence: 99%

“…Folic acid is critical to the rate of detoxification of formic acid [28]. Furthermore, in folate deficient animals, the adverse effects to the fetus after alcohol exposure are more severe compared to controls [29], [30]. Taken together, proper placental transfer of folic acid is critical to proper fetal development and can influence the fetal effects of alcohol.…”

Section: Introductionmentioning

confidence: 99%

Folic Acid Transport to the Human Fetus Is Decreased in Pregnancies with Chronic Alcohol Exposure

et al. 2012

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BackgroundDuring pregnancy, the demand for folic acid increases since the fetus requires this nutrient for its rapid growth and cell proliferation. The placenta concentrates folic acid into the fetal circulation; as a result the fetal levels are 2 to 4 times higher than the maternal level. Animal and in vitro studies have suggested that alcohol may impair transport of folic acid across the placenta by decreasing expression of transport proteins. We aim to determine if folate transfer to the fetus is altered in human pregnancies with chronic alcohol consumption.Methodology/Principal FindingsSerum folate was measured in maternal blood and umbilical cord blood at the time of delivery in pregnancies with chronic and heavy alcohol exposure (n = 23) and in non-drinking controls (n = 24). In the alcohol-exposed pairs, the fetal∶maternal serum folate ratio was ≤1.0 in over half (n = 14), whereas all but one of the controls were >1.0. Mean folate in cord samples was lower in the alcohol-exposed group than in the controls (33.15±19.89 vs 45.91±20.73, p = 0.04).Conclusions/SignificanceOur results demonstrate that chronic and heavy alcohol use in pregnancy impairs folate transport to the fetus. Altered folate concentrations within the placenta and in the fetus may in part contribute to the deficits observed in the fetal alcohol spectrum disorders.

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“…A study exploring relationships between mean daily micronutrient intakes and the same dietary patterns within the ALSPAC cohort reported that as adherence to the “Processed” and “Confectionery” dietary patterns increased, micronutrient intakes decreased, including folate, vitamin B6, vitamin C, vitamin E, and carotene (Northstone et al., ). This may have implications for fetal development, as inadequate intakes of these micronutrients during pregnancy are associated with an increased risk of EtOH‐induced fetal harm in experimental models (Gutierrez et al., ; Naseer et al., ) and fetal growth restriction and poor cognitive outcomes at 6 months in studies within human populations (Avalos et al., ; Coles et al., ). Two suggested mechanisms for these relationships are the interference of EtOH in one‐carbon metabolism and the redox state of cells (Ballard et al., ; Cohen‐Kerem and Koren, ).…”

Section: Discussionmentioning

confidence: 99%

Dietary Patterns and Alcohol Consumption During Pregnancy: Secondary Analysis of Avon Longitudinal Study of Parents and Children

Coathup

Northstone

Gray

et al. 2017

Alcohol Clin Exp Res

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Two important components of health behavior during pregnancy appear to be related: greater consumption of processed foods associated with heavier alcohol consumption, and healthier dietary choices associated with light-to-moderate alcohol intake. Potential synergistic effects of these behaviors may have implications for maternal and fetal health and warrant further investigation. A more holistic approach to addressing health behaviors in women of reproductive age is required.

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An experimental study on the effects of ethanol and folic acid deficiency, alone or in combination, on pregnant Swiss mice

Cited by 13 publications

References 32 publications

Metabolic effects of a high‐fat diet post‐weaning after low maternal dietary folate during pregnancy and lactation

Metabolic effects of a high‐fat diet post‐weaning after low maternal dietary folate during pregnancy and lactation

Folic Acid Transport to the Human Fetus Is Decreased in Pregnancies with Chronic Alcohol Exposure

Dietary Patterns and Alcohol Consumption During Pregnancy: Secondary Analysis of Avon Longitudinal Study of Parents and Children

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