An Experimental Study of Tinea Pedis and Onychomycosis of the Foot

Strauss, John S.

doi:10.1001/archderm.1957.01550190074014

Cited by 62 publications

(18 citation statements)

References 13 publications

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“…Right hand was more commonly involved, as microtrauma is more common in the hand used most. Subungual hyperkeratosis, most reliable sign of onychomycosis, was present in 88.33% cases and discoloration, earliest feature of fungal infection, was present in all cases irrespective of paronychia as reported by others 19. Our finding of onycholysis in all, except early cases, is consistent with earlier findings 17.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of clinicomycological aspects of onychomycosis

2008

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Background:Incidence of onychomycosis has increased tremendously in recent times. Relatively little work has been done on this problem in our country. Research in past has been concentrated mainly on superficial mycoses of the skin.Aim:It is a well-established fact that geographical distribution of the fungi may change from time to time; hence, this study was planned to analyze clinical, epidemiological, and mycological features of onychomycosis.Materials and Methods:Sixty patients clinically suspected and microscopically proven to have onychomycosis were taken up for the study. Nail samples, collected by scraping in 30 patients and by using a dental drill in the rest, were examined microscopically and cultured for fungus.Results and Conclusions:Forty-five fungal isolates were obtained from 60 patients. Trichophyton rubrum was the commonest fungus isolated (46.67%). Trichophyton mentagrophytes and Candida albicans accounted for 20% and 15.56% isolates, respectively. Two cases showed mixed growth of Trichophyton rubrum and Aspergillus niger in one and Trichophyton rubrum and Aspergillus fumigatus in the other. Isolation rate was higher by drilling compared to scraping, the rates being 83.33% and 66.67%, respectively. Superficial mycotic infections were present in 27 patients (45%).

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Section: Discussionsupporting

confidence: 92%

Evaluation of clinicomycological aspects of onychomycosis

2008

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“…Persistently high rates of isolation of dermatophytes and Candida in our patients are contrary to the findings of other workers [10,17] who reported decreased isolation from moist, wet and soggy lesions of severe disease. In our study, qualitative and quantitative increase in the bacterial flora, especially the Gram-negatives, in the severe cases did not hamper the increased isolation of fungus.…”

Section: Discussioncontrasting

confidence: 99%

“…We did not observe decreasing isolation rates for pathogenic fungi with increasing severity of the disease and increased bacterial population. The increased fungal isolation rate may be due to more thorough collection of scrapings from deeper areas as compared to the low isolation rates reported earlier [10,17].…”

Section: Discussionmentioning

confidence: 76%

Prevalence of bacteria and fungi in athlete's foot of varying severity and response to topical antibacterial and antifungal therapies

Talwar

Kumar²,

Ayyagiri³

et al. 1985

Med Mycol

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Ninety-six patients with clinical evidence of interdigital lesions classified as mild, moderate and severe athlete's foot were investigated for bacterial and fungal populations in the interspaces. Gram-negative bacteria, which were not found in the toe spaces of 50 normal controls, were grown in increasing numbers and with increasing frequency as the symptoms progressed from mild to severe. Gram-positive bacteria were also isolated regularly and in increasing numbers commensurate with the severity of the disease. Similarly the isolation rates of dermatophytes and Candida species were higher in patients with moderate and severe disease compared to those with mild disease. Clinical and culture responses to topical applications with framycetin, tolnaftate, miconazole and clotrimazole were also studied. In some patients the prevalence of pathogenic fungi increased as bacterial numbers decreased. The pure antibacterial framycetin brought symptomatic relief, as did the purely anti-dermatophyte substance tolnaftate, but best results were seen with two azole compounds having mixed antibacterial and antifungal properties.

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“…1 Changes in skin humidity and greasiness have been shown to affect susceptibility to local fungal infections. 8 Alternations of immune function have also been found to increase the appearance of local fungal infections. 9 Immunological changes including an overall decreased immune function have been found in SCI individuals.…”

Section: Discussionmentioning

confidence: 99%

Dermatological findings following acute traumatic spinal cord injury

et al. 2004

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Study design: Prospective study. Objective: To identify and define dermatological conditions following acute traumatic spinal cord injury (ATSCI) during inpatient rehabilitation. Setting: Spinal Cord Injury Unit, The Department of Neurological Rehabilitation, The Chaim Sheba Medical Center, Israel. Methods: During a 1-year study, all patients following ATSCI were prospectively studied for new dermatological findings during their inpatient rehabilitation. Every new dermatological finding was defined concerning its location with regard to the patient's neurological level, the time from injury to appearance and the exact dermatological diagnosis. Results: During the study year, 46 ATSCI patients were hospitalized in our department, of whom were 38 (82.6%) males and eight (17.4%) females (mean age 30.2 years). A total of 21 (45.6%) patients were tetraplegic and 25 (54.3%) paraplegic. Of the patients, 28 (60.9%) had complete neurological injuries and 18 (39.1%) incomplete. In all, 14 (30.4%) patients developed a dermatological condition. There was no significant age or sex correlation to the development of these complications. There was a greater likelihood of paraplegia (48 versus 9.5%, P ¼ 0.005) and being neurologically complete (42.9 versus 11.1%, P ¼ 0.02). The dermatological findings appeared on an average of 80.3 days after the initial neurological insult. There were a total of 22 different dermatological findings: 11 (50%) were local fungal infections, two (9.1%) psoriatic lesions, two (9.1%) hyperkeratotic lesions, two (9.1%) bacterial infections (one folliculitis, one impetigo) and single cases of seborrheic dermatitis, acne, alopecia, scabies and allergic reaction. Of the findings, 14 (63.6%) were below the neurological level, including all of the fungal infections. Conclusions: Dermatological findings are common during rehabilitation of ATSCI. The clinical impact of these findings is low, but nevertheless, they are troublesome to the patient. The most common dermatological disorder was a local fungal infection below the neurological level. Paraplegic patients are more susceptible to the development of this condition. Patient and staff education regarding proper skin care may reduce these infections.

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An Experimental Study of Tinea Pedis and Onychomycosis of the Foot

Cited by 62 publications

References 13 publications

Evaluation of clinicomycological aspects of onychomycosis

Evaluation of clinicomycological aspects of onychomycosis

Prevalence of bacteria and fungi in athlete's foot of varying severity and response to topical antibacterial and antifungal therapies

Dermatological findings following acute traumatic spinal cord injury

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