An Experimental Comparison of the Analgesic and Anti-Inflammatory Effects of Safflower Oil, Benzydamine HCl, and Naproxen Sodium

Alaiye, Ali; Kaya, Ercan; Pınarbaşlı, Mehmet Özgür; Harmanci, N; Yıldırım, Cafer; Dönmez, Dilek Burukoğlu; Cingi, Cemal

doi:10.1089/jmf.2019.0157

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…Safflower ( Carthamus tinctorius L.) is a traditional Chinese medicine with a homology of medicine and food. It is widely planted in many regions in the world and naturally contains a very large amount of flavonoids, fatty acids, pigments, volatile oils, and other active ingredients, which exhibit various physiological activities, including antibacterial [ 3 ], anti-inflammatory [ 3 ], analgesic [ 4 ], antioxidant [ 5 , 6 , 7 ], and antitumor activities [ 8 ]. In view of these active ingredients, safflower has the potential to be used as a raw material to prepare bioactive foods [ 9 ], but it also results in a very complex food matrix for the determination of pesticide residues [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Analysis of 53 Pesticides in Safflower (Carthamus tinctorius L.) by Using LC–MS/MS Coupled with a Modified QuEChERS Technique

Song¹,

Peng

Liu³

et al. 2023

Toxics

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Objective: An optimized quick, easy, cheap, effective, rugged, and safe (QuEChERS) technique was investigated and compared with the conventional QuEChERS technique for the simultaneous analysis of fifty-three pesticide residues in safflower using ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS). Method: Graphitic carbon nitride (g-C3N4) consisting of a major amount of carbon and nitrogen with a large surface area was used as a QuEChERS adsorbent instead of graphitized carbon black (GCB) for safflower extraction purification. Validation experiments were performed using spiked pesticide samples, and real samples were analyzed. Results: The linearity of the modified QuEChERS technique was evaluated with high coefficients of determination (R-2) being higher than 0.99. The limits of detection were <10 μg/kg. The spiked recoveries ranged from 70.4% to 97.6% with a relative standard deviation of less than 10.0%. The fifty-three pesticides exhibited negligible matrix effects (<20%). Thiamethoxam, acetamiprid, metolachlor, and difenoconazole were detected in real samples using an established method. Conclusion: This work provides a new g-C3N4-based modified QuEChERS technique for multi-pesticide residue analysis in complex food matrices.

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Section: Introductionmentioning

confidence: 99%

Simultaneous Analysis of 53 Pesticides in Safflower (Carthamus tinctorius L.) by Using LC–MS/MS Coupled with a Modified QuEChERS Technique

Song¹,

Peng

Liu³

et al. 2023

Toxics

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“…Several pharmacological activities, such as antioxidant ( Zemour et al ., 2019 ), antidiabetic ( Asgary et al ., 2012 ), antibacterial ( Ozkan et al ., 2021 ), analgesic, and anti-inflammatory effects ( Alaiye et al ., 2020 ), are exhibited by safflower. Notably, safflower oil is excellent in nutritional value, including 70% polyunsaturated fatty acid (linoleic acid), 10% monounsaturated oleic acid, and trace levels of stearic acid ( Zhou et al ., 2014 ; Khémiri et al ., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of synergistic activity of seed oils from Carthamus tinctorius (Safflower) and Nasturtium officinale (Watercress) on lethality of the cattle tick Hyalomma scupense (Acari: Ixodidae)

Alimi¹,

Hajri²,

Jallouli³

et al. 2022

Open Vet J

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Background: Ticks and tick-borne diseases are a severe economic and public-health problem for cattle producers. The emergence of acaricide resistance to synthetic chemical treatments has prompted interest in developing alternative tick control methods. Aim: The main objective of the current research was to identify the chemical structure of Carthamus tinctorius and Nasturtium officinale seed oils and to assess their anti-tick properties against Hyalomma scupense ticks both alone and in combination (1:1). Methods: Analytical methods were used to analyze the chemical components. For in vitro assays, adults of H. scupense were immersed in C. tinctorius and N. officinale seed oils at 100, 125, 200, and 300 mg/ml concentrations; for 5 minutes. Larvae of H. scupense were dipped in 25, 50, 100, 125, 200, and 300 mg/ml doses of seed oils; the mortality percentage was determined after 24 hours. Results: The seed oil safflower was mainly composed of linoleic acid (84.48%), followed by palmitic acid (6.54%) and stearic acid (3.77%). Meanwhile, watercress seed oil was mainly composed of linolenic acid (50.78%), gondoic acid (13.57%), linoleic acid (10.58%), palmitic acid (8.02%), and erucidic acid (6.62%). The Adults Immersion Test showed the sensitivity of ticks to C. tinctorius and N. officinale seed oil: C. tinctorius seed oil caused (95%) mortality of H. scupense at 300 mg/ml, while N. officinale seed oil induced (88.68%) mortality at the same concentration. At a 200 mg/ml concentration, C. tinctorius and N. officinale oil combined caused 100% mortality. Tested oils showed larvicidal efficacy . LC50 values for C. tinctorius and N. officinale seed oils were 84.16 and 61.78 mg/ml, respectively, in 24 hours. LC50 value of oils association (50% C. tinctorius: 50% N. officinale ) was 47.96 mg/ml. The mixture of seed oils from two plants tested against H. scupense larvae and adult females at a 1:1 ratio showed synergistic interaction. Conclusion: Seed oils tested alone, and the mixture could be used as an alternative solution in the fight against ticks.

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“…In contrast to other states, China has been employing its flowers as a therapeutic herb for years and has already established a particular growing centre. In addition, safflower contains various active ingredients, including flavonoids, quinolones, alkaloids, and safflower polysaccharides (Ambreen et al, 2018), with biological effects, including antioxidant, anti-inflammatory (Alaiye et al, 2020), and antibacterial activities (Cho et al, 2017). It has been reported that safflower improves acute cerebral infarction and ischemic stroke (Wang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Genome-wide identification and expression profiling of duplicated flavonoid 3'-hydroxylase gene family in Carthamus tinctorius L.

Hoang

Kong

Ahmad

et al. 2021

Not Bot Horti Agrobo

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Flavonoid 3′-hydroxylase (F3’H) enzyme is essential in determining the flavonoids B-ring hydroxylation pattern. It is mainly implicated in the biosynthetic pathway of cyaniding-based anthocyanins, flavonols, and flavan-3-ols. However, the evolution and regulatory mechanism of these important flavonoid hydroxylases have not been systematically investigated in safflower (Carthamus tinctorius L.). In this study, we identified 22 duplicatedCtF3'H-encoding genes from safflower through genome-wide prediction and conservation analysis. Phylogenetic analysis revealed the pattern of conservation and divergence of CtF3'Hs encoding proteins and their homologs from different plant species. The distribution of conserved protein motifs and cis-regulatory units suggested several structural components that could be crucial in deciphering the final function of CtF3'H proteins. Furthermore, the results of RNA-seq and qRT-PCR assay in different flowering tissues suggested differential expression level of CtF3’H genes during flower development. Based on the unique homology of CtF3’H5 with flavonoid 3’ hydroxylases from other plant species, further validation of CtF3’H5 was carried out. The transient expression of CtF3’H5 in onion epidermal cells implied that the subcellular localization of the fusion construct containing CtF3’H5 and GFP was predominantly detected in the plasma membrane. Similarly, the prokaryotic expression and western blot hybridization of CtF3’H5 demonstrated the detection of a stable 50.3kD target protein. However, more efforts are needed to further extend the functional validation of CtF3’H5 in safflower. This study provides a fundamental gateway for future functional studies and understanding the genetic evolution of F3'Hs in plants.

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An Experimental Comparison of the Analgesic and Anti-Inflammatory Effects of Safflower Oil, Benzydamine HCl, and Naproxen Sodium

Cited by 7 publications

References 15 publications

Simultaneous Analysis of 53 Pesticides in Safflower (Carthamus tinctorius L.) by Using LC–MS/MS Coupled with a Modified QuEChERS Technique

Simultaneous Analysis of 53 Pesticides in Safflower (Carthamus tinctorius L.) by Using LC–MS/MS Coupled with a Modified QuEChERS Technique

Efficacy of synergistic activity of seed oils from Carthamus tinctorius (Safflower) and Nasturtium officinale (Watercress) on lethality of the cattle tick Hyalomma scupense (Acari: Ixodidae)

Genome-wide identification and expression profiling of duplicated flavonoid 3'-hydroxylase gene family in Carthamus tinctorius L.

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