2016
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Abstract: The present study was planned to optimize and validate an expedient reverse-phase high chromatography (RP-HPLC) based protocol for the analysis of deferoxamine (DFO) and ferrioxamine (FO) in urinary execration of patients suffering β-thalassemia major. The optimized RP-HPLC method was found to be linear over the wide range of DFO and FO concentration (1-90 μg/mL) with appreciable recovery rates (79.64-97.30%) of quality controls at improved detection and quantitation limits and acceptable inter and intraday va… Show more

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Cited by 8 publications
(3 citation statements)
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“…Three HA—salicylhydroxamic acid (SHA), suberanilohydroxamic acid (SAHA), and deferoxamine (DFA)—are already commonly used in medicine [ 1 , 4 , 5 ]. However, these medications have been linked with various acute and chronic side effects [ 6 ]. The determination of HA is a task of great importance.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Three HA—salicylhydroxamic acid (SHA), suberanilohydroxamic acid (SAHA), and deferoxamine (DFA)—are already commonly used in medicine [ 1 , 4 , 5 ]. However, these medications have been linked with various acute and chronic side effects [ 6 ]. The determination of HA is a task of great importance.…”
Section: Introductionmentioning
confidence: 99%
“…Efficient and selective analytical methods for HA determination in plasma and urine samples are required for both dose regulation and clinical studies (pharmacokinetic–pharmacodynamic parameters, efficiency of the drugs) [ 6 , 7 ]. Up to date, several analytical methods have been used for HA determination: chromatographic [ 5 , 6 , 7 , 8 , 9 ], electrochemical [ 10 , 11 ], and spectrophotometric [ 12 , 13 ]. Some of the procedures are based on complexes formation between HA and metals [ 9 , 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…Previously, DFX was determined in bulk and dosage forms after complex formation with iron by chromatographic methods using fluorometric, electrochemical and mass detectors [13][14][15]. In addition, HPLC-based methods based on the application of post-column derivatization technique for the detection of DFX are available [16].…”
Section: Introductionmentioning
confidence: 99%