1995
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An evaluation of musk xylene in a battery of genotoxicity tests
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Cited by 25 publications
(7 citation statements)
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Abstract
Smart CitationsHow this paper cites the one you are viewing
“…MX was uniformly negative in a battery of short-term in vitro genotoxicity tests, and unlike other nitroaromatic compounds, it was also negative in an in vivo-in vitro assay of unscheduled DNA synthesis (UDS) [8][9][10]. These results suggest that MX and its metabolites do not react with DNA and that the liver tumors probably resulted from nongenotoxic mechanisms.…”
Section: Introduction
mentioning
confidence: 70%
“…In a similar manner, our results indicated that nitroreduction of MX was a very important determinant of the molecular effects of this chemical. However, MX up to doses of 5000 mg/kg does not show any genotoxic potential in the in vivo-in vitro UDS assay [10]. Because these high doses should produce significant levels of amine metabolites [19], the negative results of the UDS assays indicate that amine metabolites of MX do not generate genotoxic intermediates.…”
Section: Discussion
mentioning
confidence: 97%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…MX was uniformly negative in a battery of short-term in vitro genotoxicity tests, and unlike other nitroaromatic compounds, it was also negative in an in vivo-in vitro assay of unscheduled DNA synthesis (UDS) [8][9][10]. These results suggest that MX and its metabolites do not react with DNA and that the liver tumors probably resulted from nongenotoxic mechanisms.…”
Section: Introduction
mentioning
confidence: 70%
“…In a similar manner, our results indicated that nitroreduction of MX was a very important determinant of the molecular effects of this chemical. However, MX up to doses of 5000 mg/kg does not show any genotoxic potential in the in vivo-in vitro UDS assay [10]. Because these high doses should produce significant levels of amine metabolites [19], the negative results of the UDS assays indicate that amine metabolites of MX do not generate genotoxic intermediates.…”
Section: Discussion
mentioning
confidence: 97%
Smart CitationsHow this paper cites the one you are viewing
“…This concept extends beyond fragrance ingredients. For example, the knowledge that several nitroaromatic substances not used in fragrances are genotoxic led to careful examination of this endpoint with structurally similar fragrance materials (Api et al, 1995(Api et al, , 1996.…”
Section: Consideration Of Chemical Structures
mentioning
confidence: 99%
Smart CitationsHow this paper cites the one you are viewing
“……”
Section: Introduction
mentioning
confidence: 97%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…MX was uniformly negative in a battery of short-term in vitro genotoxicity tests, and unlike other nitroaromatic compounds, it was also negative in an in vivo-in vitro assay of unscheduled DNA synthesis (UDS) [8][9][10]. These results suggest that MX and its metabolites do not react with DNA and that the liver tumors probably resulted from nongenotoxic mechanisms.…”
Section: Introduction
mentioning
confidence: 70%
“…In a similar manner, our results indicated that nitroreduction of MX was a very important determinant of the molecular effects of this chemical. However, MX up to doses of 5000 mg/kg does not show any genotoxic potential in the in vivo-in vitro UDS assay [10]. Because these high doses should produce significant levels of amine metabolites [19], the negative results of the UDS assays indicate that amine metabolites of MX do not generate genotoxic intermediates.…”
Section: Discussion
mentioning
confidence: 97%
Smart CitationsHow this paper cites the one you are viewing
“…This concept extends beyond fragrance ingredients. For example, the knowledge that several nitroaromatic substances not used in fragrances are genotoxic led to careful examination of this endpoint with structurally similar fragrance materials (Api et al, 1995(Api et al, , 1996.…”
Section: Consideration Of Chemical Structures
mentioning
confidence: 99%
Smart CitationsHow this paper cites the one you are viewing
“……”
Section: Introduction
mentioning
confidence: 97%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…MX was uniformly negative in a battery of short-term in vitro genotoxicity tests, and unlike other nitroaromatic compounds, it was also negative in an in vivo-in vitro assay of unscheduled DNA synthesis (UDS) [8][9][10]. These results suggest that MX and its metabolites do not react with DNA and that the liver tumors probably resulted from nongenotoxic mechanisms.…”
Section: Introduction
mentioning
confidence: 70%
“…In a similar manner, our results indicated that nitroreduction of MX was a very important determinant of the molecular effects of this chemical. However, MX up to doses of 5000 mg/kg does not show any genotoxic potential in the in vivo-in vitro UDS assay [10]. Because these high doses should produce significant levels of amine metabolites [19], the negative results of the UDS assays indicate that amine metabolites of MX do not generate genotoxic intermediates.…”
Section: Discussion
mentioning
confidence: 97%
Smart CitationsHow this paper cites the one you are viewing
“…This concept extends beyond fragrance ingredients. For example, the knowledge that several nitroaromatic substances not used in fragrances are genotoxic led to careful examination of this endpoint with structurally similar fragrance materials (Api et al, 1995(Api et al, , 1996.…”
Section: Consideration Of Chemical Structures
mentioning
confidence: 99%
Smart CitationsHow this paper cites the one you are viewing
“……”
Section: Introduction
mentioning
confidence: 97%