2002
DOI: 10.1002/cncr.10427
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Abstract: BACKGROUNDThere are large geographic gradients in mortality rates for a number of cancers in the U.S. (e.g., rates are approximately twice as high in the northeast compared with the southwest). Risk factors such as diet fail to explain this variation. Previous studies have demonstrated that the geographic distributions for five types of cancer are related inversely to solar radiation. The purpose of the current study was to determine how many types of cancer are affected by solar radiation and how many prematu… Show more

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Cited by 650 publications
(479 citation statements)
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“…We separately added variables for body mass index (BMI), serum selenium, cholesterol and retinol, and cholesterol and a-tocopherol and found that the serum 25(OH)D associations were independent of these exposures and that there was no evidence of interaction (data not shown). (Launoy et al, 1998;Grant, 2002;Giovannucci et al, 2006), we found that higher serum 25(OH)D concentration was associated with increased risk of ESCC, but not with cardia or noncardia gastric cancer. This increased risk of ESCC appeared to vary directly with increasing serum concentrations and there was no evidence of thresholds or deviations from linearity.…”
Section: Resultsmentioning
confidence: 66%
See 1 more Smart Citation
“…We separately added variables for body mass index (BMI), serum selenium, cholesterol and retinol, and cholesterol and a-tocopherol and found that the serum 25(OH)D associations were independent of these exposures and that there was no evidence of interaction (data not shown). (Launoy et al, 1998;Grant, 2002;Giovannucci et al, 2006), we found that higher serum 25(OH)D concentration was associated with increased risk of ESCC, but not with cardia or noncardia gastric cancer. This increased risk of ESCC appeared to vary directly with increasing serum concentrations and there was no evidence of thresholds or deviations from linearity.…”
Section: Resultsmentioning
confidence: 66%
“…This method does not account for UVB generated vitamin D, the primary vitamin D source for most people. An ecologic study of UVB radiation and oesophageal and stomach cancer in the United States found negative correlations of similar magnitude between UVB exposure and oesophageal or stomach cancer rates (Grant, 2002). This study is subject to all the limitations attendant to ecologic studies.…”
Section: Resultsmentioning
confidence: 83%
“…In ecological studies of populations and sunlight exposure (no individual data) sunlight has been found to have a protective effect for prostate cancer [136], ovarian cancer [137], and breast cancer [138]. Recently Grant found that sunlight was also protective for bladder, endometrial, renal cancer, multiple myeloma, and Non-Hodgkins lymphoma in Europe [139] and bladder, esophageal, kidney, lung, pancreatic, rectal, stomach, and corpus uteri cancer in the USA [140]. Several prospective studies of vitamin D and cancer have also shown a protective effect of vitamin D (see Table 5).…”
Section: Reviewmentioning
confidence: 99%
“…[7][8][9][10] For such cancers, mortality rates are about twice as high in the northeast as in the southwest and strongly inversely correlated with solar UVB radiation. 7,10,11 In addition, 6 types of cancer (breast, colon, endometrial, esophageal, ovarian and non-Hodgkin's lymphoma) are inversely correlated to both solar UVB radiation and rural residence in combination. 11 Urban residence is considered to reduce UVB exposure compared to rural residence in that it does not correlate with any other factor, such as lung cancer.…”
Section: Dear Sirmentioning
confidence: 99%