2003
DOI: 10.1074/jbc.m304323200 View full text |Buy / Rent full text
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Abstract: tRNA-guanine transglycosylase (TGT, 1 EC 2.4.2.29) catalyzes a base-exchange reaction involved in the post-transcriptional modification of tRNAs from the three domains of life (archaea, eubacteria, and eukarya). In both eubacteria and eukarya, TGT activity ultimately leads to the incorporation of queuine (Q, 7-(4,5-cis-dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanine, Fig.

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