Abstract:The recent development of the analytical techniques offers the unprecedented possibility to study simultaneously concentration of dozens of elements in the same biological matrix sample of 0.5–1.0 g (multielement profiles). The first part of this essay entitled “Think globally… An outline of trace elements in health and disease” aims to introduce the reader to the fascinating field of elements, there importance to our nutrition, their essentiality, deficiency, toxicity and bioavailability to the body and their… Show more
“…The primary goal of this paper is to draw attention of clinicians and other public health personnel that body iodine status is only partially assessed by measuring the thyroid gland hormones, instead of measuring iodine directly in some suitable biological matrix tissue like 11 hair [11]. Indeed, when iodine intake is abnormally low, adequate secretion of thyroid hormones may still be achieved by marked modification of thyroid activity.…”
Section: Resultsmentioning
confidence: 99%
“…This prospective, observational, cross-sectional, and exploratory study was approved by the Ethical Committee of the Institute for the Research and Development of the Sustainable Eco Systems (IRES) and conducted by strict adherence to the Declaration of Helsinki on Human Subject Research [10], and to the complementary Croatian national bylaws and regulations [11]. Every subject gave his/her written consent to participate in the 5 study and filled out a short questionnaire on his/her health status and medical history [12] (data not shown).…”
“…The primary goal of this paper is to draw attention of clinicians and other public health personnel that body iodine status is only partially assessed by measuring the thyroid gland hormones, instead of measuring iodine directly in some suitable biological matrix tissue like 11 hair [11]. Indeed, when iodine intake is abnormally low, adequate secretion of thyroid hormones may still be achieved by marked modification of thyroid activity.…”
Section: Resultsmentioning
confidence: 99%
“…This prospective, observational, cross-sectional, and exploratory study was approved by the Ethical Committee of the Institute for the Research and Development of the Sustainable Eco Systems (IRES) and conducted by strict adherence to the Declaration of Helsinki on Human Subject Research [10], and to the complementary Croatian national bylaws and regulations [11]. Every subject gave his/her written consent to participate in the 5 study and filled out a short questionnaire on his/her health status and medical history [12] (data not shown).…”
“…The primary goal of this study is to draw the attention of clinicians and other public health personnel to the fact that iodine status should ideally be determined by measuring iodine directly in a suitable biological matrix tissue such as hair (10). Because UI data frequency distribution showed excessive kurtosis and skewedness when presented on a linear scale (18), we have concerns about using clustered (pooled) spot UI data for assessing human iodine status.…”
Section: Discussionmentioning
confidence: 99%
“…This prospective, observational, cross-sectional, and exploratory study was approved by the Ethical Committee of the Institute for the Research Development of the Sustainable Eco Systems, and conducted by strict adherence to the Declaration of Helsinki on Human Subject Research (20) and to the complementary Croatian national bylaws and regulations (10). Every subject gave his/her written consent to participate in the study and filled out a short questionnaire on his/her health status and medical history (21) (data not shown).…”
Section: Methodsmentioning
confidence: 99%
“…The fairly common clinical entity of endemic goiter is the goiter induced by iodine deficiency (9). Recently, we demonstrated that iodine deficiency is strongly associated with clinically manifest human depression (10).…”
Hair appears to be a valuable and robust biological indicator tissue for assessing long-term iodine status. We propose that an adequate iodine status corresponds with hair iodine uptake saturation of 0.565-0.739 μg/g (55-65%).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.