An erodible polythiophene-based composite for biomedical applications

Conducting Polymer-Based Multilayer Films for Instructive Biomaterial Coatings

“…We found that HDFs adhered to and proliferated on the surface of all of the substrates over the period of 4 days. HDFs cultured on the TCP control substrates proliferated somewhat faster than on the PEDOT-PSS-based or PEDOT-S-based films (Figure 2E), which is similar to the findings of Wallace and co-workers with mouse derived L929 and C2C12 cells on polythiophene-based films [18]. …”

“…Conductive multilayer films have been prepared from a variety of organic electronic components, often for applications in energy, of which a number of examples based on CPs exist [17]. Wallace and co-workers reported the preparation of bioerodible CP-based multilayer films based on an anionic sulfonate-displaying polythiophene derivative (with a M w = 13,160 Da and M n = 6682 Da as determined by GPC) and cationic polyethyleneimine (17 kDa) [18], both of which are below the renal filtration limit of approximately 50 kDa [11], and the films were shown to be suitable for the growth and proliferation of cells derived from the connective and muscle tissue of mice (L929 and C2C12 cells, respectively) [18]. They subsequently showed that it was possible to prepare CP-based multilayer films based solely on anionic and cationic polythiophene derivatives that could be disassembled upon the application of an electrochemical trigger (a potential step of 650 mV for 19–42 h) [19].…”

A conducting polymer with enhanced electronic stability applied in cardiac models

“…Among the conductive materials used in bioelectronics, conducting polymers (CPs) have attracted much attention over recent years because of their ability to conduct both electronically and ionically ( 1 ), to be processed into scaffolds ( 2 ), and to be rendered biodegradable ( 3 , 4 ). In tissue engineering, bioelectronic devices are being developed with the anticipation of reestablishing communication between interrupted cells.…”

Neural Engineering

“…Fully bioerodible, electroactive thiophenes have been investigated as layer-by-layer (LBL) systems with polyethyleneimine (PEI) and as hydrogels and evidenced to be biocompatible by promoting L929 fi broblast adhesion and proliferation (Mawad et al 2011(Mawad et al , 2012. The polythiophene derivative poly (3,4-ethylenedioxythiophene) (PEDOT) is the most commonly investigated ICP for use in neural electrodes due to its non-biodegradability, thermal stability, high optical transparency, and low redox potential (Richardson-Burns et al 2007a , b ;Ludwig et al 2006 ;Xiao et al 2004 ;Cui and Martin 2003 ;Harris et al 2013Harris et al , 2015Jin et al 2013 ).…”